Understanding mechanisms of sex programming of cardiovascular development. The goal of this project is to track the influence of sex and sex hormones through crucial lifespan timepoints to define how specific patterns of gene signalling determine adult cardiovascular traits at cell, tissue and systems level. Sexually distinct cardiovascular traits are conserved across mammalian species. Early developmental events are known to be important in influencing later adult characteristics, but how adult ....Understanding mechanisms of sex programming of cardiovascular development. The goal of this project is to track the influence of sex and sex hormones through crucial lifespan timepoints to define how specific patterns of gene signalling determine adult cardiovascular traits at cell, tissue and systems level. Sexually distinct cardiovascular traits are conserved across mammalian species. Early developmental events are known to be important in influencing later adult characteristics, but how adult cardiovascular functions are ‘programmed’ differently for males and females is not understood. The project aims to uncover the importance of the placenta in regulating foetus exposure to sex steroids and the crucial effects of the pubertal hormone surge in shaping cardiovascular phenotypes of male and female offspring.Read moreRead less
Glucocorticoid receptor-αD1 modulates stress and inflammation . Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using innova ....Glucocorticoid receptor-αD1 modulates stress and inflammation . Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using innovative molecular biology approaches, GRalphaD1's function will be examined to provide a deeper understanding of how stress regulates inflammation in animal reproduction. The project aims to enhance interdisciplinary collaborations with expected benefits including a paradigm shift in our knowledge in this field.Read moreRead less
Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations t ....Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.Read moreRead less
Oxygen Signalling in Grapevine Bud Dormancy. Dormancy is an important economic and ecological trait of many trees and crop plants, including most commercially valuable fruit species. This project aims to: define oxygen and radicals of oxygen as central cues of grapevine bud development and dormancy; identify and model the developmental processes that occur during dormancy onset, maintenance and release (bud burst); as well as to identify the molecular and biochemical regulators of oxygen signals ....Oxygen Signalling in Grapevine Bud Dormancy. Dormancy is an important economic and ecological trait of many trees and crop plants, including most commercially valuable fruit species. This project aims to: define oxygen and radicals of oxygen as central cues of grapevine bud development and dormancy; identify and model the developmental processes that occur during dormancy onset, maintenance and release (bud burst); as well as to identify the molecular and biochemical regulators of oxygen signals in bud dormancy. The knowledge generated could provide a platform to test impacts of climate change on fruit and tree species, and lead to better management of fruit and tree species in agricultural and ecological systems.Read moreRead less
New genetic mechanisms linking flowering, growth habit and yield in legumes. This project aims to investigate the genetic control of flowering and flowering-related traits in legumes, an important group of crop plants. The regulation of flowering by environmental factors has a major influence on plant yield and is important for adaptation in natural and agricultural settings. However, it is poorly understood at the molecular level. This project aims to use induced genetic variation and transcrip ....New genetic mechanisms linking flowering, growth habit and yield in legumes. This project aims to investigate the genetic control of flowering and flowering-related traits in legumes, an important group of crop plants. The regulation of flowering by environmental factors has a major influence on plant yield and is important for adaptation in natural and agricultural settings. However, it is poorly understood at the molecular level. This project aims to use induced genetic variation and transcriptome analysis to define new genes and genetic mechanisms through which flowering is regulated by day length and temperature, and to explore the molecular links between flowering and other developmental processes including seed development. This should extend our understanding of how plant architecture, reproduction and yield are regulated by the environment, and address several agronomic issues.Read moreRead less
Periconceptional Nutrition And The Programming Of Obesity
Funder
National Health and Medical Research Council
Funding Amount
$468,879.00
Summary
Mothers who enter pregnancy with a high body mass index are at risk of developing diabetes in pregnancy and of having a large baby who will be at increased risk of developing obesity in childhood and later life. Heavy mothers therefore have heavy babies and these babies go on to become heavy adults. This grant will determine the separate contributions of exposure of the embryo to high nutrition and exposure of the fetus in late gestation to high maternal nutrition.
Decoding the rules of fate, attraction and cell migration in perciform fish. This project will interrogate primordial germ cell migration to reveal new insights into the molecular basis of cell migration and chemosensory communication. Key residues needed for ligand-receptor binding and environmental impacts on migration will be investigated with valuable implications in reproductive developmental biology and applied science.
Novel mechanisms integrating the central and autonomic nervous system. This project aims to define molecular mechanisms controlling the exquisite connectivity of neurons in different parts of the body. The ability of higher-vertebrates to respond to different environmental conditions is essential for life, evolution, health, reproduction and growth, and is reliant on the autonomic nervous system. However, how the autonomic nervous system is integrated with the central nervous system to control h ....Novel mechanisms integrating the central and autonomic nervous system. This project aims to define molecular mechanisms controlling the exquisite connectivity of neurons in different parts of the body. The ability of higher-vertebrates to respond to different environmental conditions is essential for life, evolution, health, reproduction and growth, and is reliant on the autonomic nervous system. However, how the autonomic nervous system is integrated with the central nervous system to control holistic physiological responses is largely unknown. By deciphering how neural networks are formed this project aims to provide broad biological insight to wiring of the entire nervous system which is likely to have significant implications for the formation of synthetic neural networks and for regeneration.Read moreRead less