Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Subcellular recruitment of a RhoA ubiquitination complex by Rnd proteins. This study addresses a novel molecular mechanism through which members of the Rnd family of GTP-binding proteins regulate the morphology and migration of immature nerve cells of the developing nervous system. This study has broad implications for the understanding of cell migration during embryo development, as well as in health and disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561030
Funder
Australian Research Council
Funding Amount
$441,100.00
Summary
Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiative ....Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiatives in developmental and cellular biology. This large-scale, high-resolution expression profiling infrastructure is required to maintain international competitiveness and will dramatically improve our gene discovery, functional assessment and understanding of vertebrate development.Read moreRead less
Quality and outcomes of individual supported living arrangements for adults with intellectual and developmental disabilities. This project identifies service quality aspects contributing to positive outcomes in individual supported living arrangements that enable adults with developmental disabilities to live in their own homes. 150 arrangements will be evaluated across Western Australia, New South Wales and Victoria, providing evidence of service quality in support of people with disability hav ....Quality and outcomes of individual supported living arrangements for adults with intellectual and developmental disabilities. This project identifies service quality aspects contributing to positive outcomes in individual supported living arrangements that enable adults with developmental disabilities to live in their own homes. 150 arrangements will be evaluated across Western Australia, New South Wales and Victoria, providing evidence of service quality in support of people with disability having choice and control in their living arrangements.Read moreRead less
Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. This project will work with the Aboriginal Community to identify, evaluate and recommend an appropriate Competent Authority legal structure so Australia can meet the requirements of the Nagoya Protocol. This Protocol calls for a Competent Authority to govern and administer a legal framework that ensures Indigenous communities’ informed consent is obt ....Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. Garuwanga: Forming a Competent Authority to protect Indigenous knowledge. This project will work with the Aboriginal Community to identify, evaluate and recommend an appropriate Competent Authority legal structure so Australia can meet the requirements of the Nagoya Protocol. This Protocol calls for a Competent Authority to govern and administer a legal framework that ensures Indigenous communities’ informed consent is obtained for access to their traditional knowledge, and that establishes fair and equitable benefit-sharing mechanisms for use of that knowledge. This project will work with the Indigenous community to address concerns over the form, independence and funding of the Authority so Indigenous knowledge and culture can be protected and shared.Read moreRead less
Transition to retirement by adults with chronic disabilities: increasing community capacity. This project will contribute to healthy, productive ageing by people with chronic disabilities. This group are living longer and will retire from their disability-specific supported employment and day program services. They then risk social exclusion, loneliness and associated poor health outcomes. This project will provide training and support to local community groups and voluntary work settings, to in ....Transition to retirement by adults with chronic disabilities: increasing community capacity. This project will contribute to healthy, productive ageing by people with chronic disabilities. This group are living longer and will retire from their disability-specific supported employment and day program services. They then risk social exclusion, loneliness and associated poor health outcomes. This project will provide training and support to local community groups and voluntary work settings, to increase community capacity to support this group to participate actively in and contribute to their community in retirement. This will result in increased participation by this group and improvements in their well-being. Training resources developed by the project will be available to disability service providers nationally.Read moreRead less
Performance of waste stabilisation ponds: controlling factors, novel performance indicators, and risk assessment. As the world population increases, maintaining robust, cost-effective and environmentally safe wastewater treatment systems is of vital importance. This project will enhance the ability to design, operate and manage Australia's extensive wastewater infrastructure for safer and more sustainable water resources in Australia and the world.
On-line monitoring of cyanobacteria to predict coagulant doses and powdered activated carbon application in water treatment. Cyanobacteria, more commonly known as blue-green algae, can impact water quality by releasing toxins that can be harmful to human health and imparting unpleasant taste and odours to the water. This project will support the water industry in managing these risks by providing a rapid, on-line tool to assist in their removal during water treatment.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less