Moving beyond crisis management: Creating a future for people with disabilities living with ageing parents. The needs of thousands of people with disabilities being cared for by ageing parents are beyond the capacity of our existing formal mechanisms for providing care. In order to mitigate this national crisis in support, this research will establish effective, resource efficient support strategies where there are currently no plans in place for future care arrangements. By enhancing the capaci ....Moving beyond crisis management: Creating a future for people with disabilities living with ageing parents. The needs of thousands of people with disabilities being cared for by ageing parents are beyond the capacity of our existing formal mechanisms for providing care. In order to mitigate this national crisis in support, this research will establish effective, resource efficient support strategies where there are currently no plans in place for future care arrangements. By enhancing the capacity of the community to provide support the benefit of existing formal supports will be extended to address the needs of more families. This project will position Australian disability research and support at the forefront of international efforts to legitimize the claim of people with disabilities and their families on community resources.Read moreRead less
Neural migration: Which cells advance and which stay behind? This project aims to examine the neural crest cells that colonise the developing gut and to identify why some cells advance while others stay behind to populate a region. Directed cell migration is essential for normal development, including for the nervous system. In most of the migratory cell populations that have been analysed to date, all of the cells migrate as a collective from one location to another. However, there are also mi ....Neural migration: Which cells advance and which stay behind? This project aims to examine the neural crest cells that colonise the developing gut and to identify why some cells advance while others stay behind to populate a region. Directed cell migration is essential for normal development, including for the nervous system. In most of the migratory cell populations that have been analysed to date, all of the cells migrate as a collective from one location to another. However, there are also migratory cell populations that must populate the areas through which they migrate, and thus some cells get left behind while others advance. The planned data are likely to be relevant to other cell populations that also populate the areas through which they migrate, including neural crest-derived melanocytes and Schwann cell precursors.Read moreRead less
Wiring the gut's nervous system: formation and maturation of synapses. This project aims to determine how nerve circuits controlling intestinal functions develop; specifically how communication between specific nerve cells is established once they appear in the embryonic gut. It will fill a major hole in existing knowledge of mechanisms regulating the development of normal digestive behaviours.
Electrical activity in early enteric neuron development. Intestinal movements and secretion are critical to the good health and nutrition of both humans and animals. These functions are regulated by a large nervous system contained within the intestinal wall, the enteric nervous system. This project will identify how enteric nerve cells develop and how their behaviour influences the development of other enteric nerve cells. This is will provide an important base for more applied research aime ....Electrical activity in early enteric neuron development. Intestinal movements and secretion are critical to the good health and nutrition of both humans and animals. These functions are regulated by a large nervous system contained within the intestinal wall, the enteric nervous system. This project will identify how enteric nerve cells develop and how their behaviour influences the development of other enteric nerve cells. This is will provide an important base for more applied research aimed at developing treatments for diseases like chronic constipation and irritable bowel syndrome. It will also contribute to the growing knowledge about how epigenetic factors can modify genetically programmed development within the nervous system.Read moreRead less
Cell cycle and enteric neuron and glial differentiation. Enteric neurons arise from a very small starting population of precursor (neural crest) cells, most of which emigrate from the hindbrain, and colonise the developing gut. Over a protracted period of time the precursors proliferate and differentiate into glia and many different types of neurons. Cell cycle exit is a critical event in the development of many neuron types, largely because the time at which cells exit from the cell cycle lim ....Cell cycle and enteric neuron and glial differentiation. Enteric neurons arise from a very small starting population of precursor (neural crest) cells, most of which emigrate from the hindbrain, and colonise the developing gut. Over a protracted period of time the precursors proliferate and differentiate into glia and many different types of neurons. Cell cycle exit is a critical event in the development of many neuron types, largely because the time at which cells exit from the cell cycle limits the number of neurons that will be generated. We will determine whether exit from the cell cycle contributes to the differentiation and specification of enteric neurons and glia.Read moreRead less
Improving payments for ecosystem services efficacy. This project aims to improve the cost-effectiveness of payments for ecosystem services (PES) programs in settings where deforestation risk is high. The project introduces a field experiment in Uganda in order to determine effective methods for monitoring compliance and setting payment levels. The project intends to examine whether program impacts are undermined by displacement of deforestation and if there are poverty reduction trade-offs inher ....Improving payments for ecosystem services efficacy. This project aims to improve the cost-effectiveness of payments for ecosystem services (PES) programs in settings where deforestation risk is high. The project introduces a field experiment in Uganda in order to determine effective methods for monitoring compliance and setting payment levels. The project intends to examine whether program impacts are undermined by displacement of deforestation and if there are poverty reduction trade-offs inherent in program design. The project expects to establish the costs of foregone production from land enrolled in the program, which are largely unknown. The findings will support efforts to create low cost technologies to solve conservation challenges and assist with the efficient allocation of scarce resources for environmental protection in both Australian and international contexts.Read moreRead less
Ageing in a developing country and its effects on intra-household resource allocation. Indonesia, our largest neighbour and our third largest recipient of AID, is among the fastest-growing elderly populations in Southeast Asia. Ongoing cultural and economic change means that the traditional reliance of elderly on family support is breaking down leaving the country's social fabric vulnerable. Understanding the linkages between ageing, ill-health and the labour market responses at the household le ....Ageing in a developing country and its effects on intra-household resource allocation. Indonesia, our largest neighbour and our third largest recipient of AID, is among the fastest-growing elderly populations in Southeast Asia. Ongoing cultural and economic change means that the traditional reliance of elderly on family support is breaking down leaving the country's social fabric vulnerable. Understanding the linkages between ageing, ill-health and the labour market responses at the household level is the path to effectively intervene in the link between age and poverty and to successfully design policy that facilitates improvements in women's social status.Read moreRead less
Understanding Foster Carers' Motivations: Personal, Political & Historical Perspectives on Care Provision in Australia. Due to the increasing number of children in care nationally, and the declining number of available foster care placements, there is current considerable interest in understanding the most appropriate means to recruit and retain foster carers. This project involves a national interview study of carers from several Australian States to understand the factors that most strongly mo ....Understanding Foster Carers' Motivations: Personal, Political & Historical Perspectives on Care Provision in Australia. Due to the increasing number of children in care nationally, and the declining number of available foster care placements, there is current considerable interest in understanding the most appropriate means to recruit and retain foster carers. This project involves a national interview study of carers from several Australian States to understand the factors that most strongly motivate people to become carers. Based on interviews with carers and other important stakeholders, the results will help us to understand the nature of the foster-carer role within the current political and social climate and help inform future national recruitment strategies.
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Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The cur ....Cracking the code of snails to elucidate parasite disease transmission. In Australia, a disease caused by liver flukes causes major economic losses to livestock production. The role of Australian pond snails as intermediate hosts for this parasite is poorly understood. This project aims to explore the phylogeography, biology and genomics of these snails. It expects to create novel molecular resources for important snail species and verify their roles as key vectors of flatworm parasites. The curation of genomic and transcriptomic data sets, and elucidation of snail–parasite interactions will underpin the development of environmental diagnostic tests and deliver a new generation of intervention strategies to reduce the burden of liver fluke disease through the control of their snail intermediate hosts.Read moreRead less
Subcellular recruitment of a RhoA ubiquitination complex by Rnd proteins. This study addresses a novel molecular mechanism through which members of the Rnd family of GTP-binding proteins regulate the morphology and migration of immature nerve cells of the developing nervous system. This study has broad implications for the understanding of cell migration during embryo development, as well as in health and disease.