CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule developmen ....CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule development. New knowledge of the plant growth processes through mechanistic analysis of organ induction provides the tools to optimise the legume's productivity, quality, and environment adaptation.Read moreRead less
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200013
Funder
Australian Research Council
Funding Amount
$4,979,922.00
Summary
ARC Research Hub for advanced breeding to transform prawn aquaculture. ARC Research Hub for advanced breeding to transform prawn aquaculture. This Research Hub aims to bring together world-leading animal geneticists, research and service providers, and Australia's largest prawn farm to gather the genomic resources, commercial phenotypic data, and apply cutting-edge genetic and genomic selection methodologies, leading to the transformative improvement program for a black tiger prawn aquaculture s ....ARC Research Hub for advanced breeding to transform prawn aquaculture. ARC Research Hub for advanced breeding to transform prawn aquaculture. This Research Hub aims to bring together world-leading animal geneticists, research and service providers, and Australia's largest prawn farm to gather the genomic resources, commercial phenotypic data, and apply cutting-edge genetic and genomic selection methodologies, leading to the transformative improvement program for a black tiger prawn aquaculture species globally.Read moreRead less
More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and po ....More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and policies are being established. The researchers will work alongside housing providers and selected Indigenous communities in Western Australia and Northern Territory to develop procurement, construction and housing management practices that will meet the critical need for more affordable, appropriate and sustainable housing.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
School principals’ diminishing wellbeing. School principals’ diminishing wellbeing. This project aims to investigate the effect of State Education Departments’ policy interventions designed to improve school principals’ flagging wellbeing. Increasing competition, accountability and public scrutiny make principals stressed; since their influence on students is second only to teachers’, this threatens Australia’s socioeconomic outcomes. The project will map policy interventions to changes in princ ....School principals’ diminishing wellbeing. School principals’ diminishing wellbeing. This project aims to investigate the effect of State Education Departments’ policy interventions designed to improve school principals’ flagging wellbeing. Increasing competition, accountability and public scrutiny make principals stressed; since their influence on students is second only to teachers’, this threatens Australia’s socioeconomic outcomes. The project will map policy interventions to changes in principals’ motivation and wellbeing, and share information about the most productive and cost effective interventions with key stakeholders across Australia. This research could reverse the declining wellbeing of Australia’s school leaders.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less