Discovery Early Career Researcher Award - Grant ID: DE150101574
Funder
Australian Research Council
Funding Amount
$368,583.00
Summary
Evolution and Adaptation of the Human Microbiome. The bacteria within the human body (microbiome) are vital to human health, and alterations to these intricate microbial communities are now associated with disease. Using ancient DNA, this project aims to examine the evolutionary history of the human microbiome by exploring ancient bacterial communities preserved in calcified dental plaque (calculus) over the past 10 000 years. This will provide valuable information that reveals how these bacteri ....Evolution and Adaptation of the Human Microbiome. The bacteria within the human body (microbiome) are vital to human health, and alterations to these intricate microbial communities are now associated with disease. Using ancient DNA, this project aims to examine the evolutionary history of the human microbiome by exploring ancient bacterial communities preserved in calcified dental plaque (calculus) over the past 10 000 years. This will provide valuable information that reveals how these bacterial communities respond to alterations in human diet, environment, culture, and location. By monitoring changes in a natural modern system, this project aims to determine how these microbial communities established themselves within the human body, elucidating how the microbiome may respond in the future.Read moreRead less
Stories from the past: the impact of industrialisation on the human microbiome. This project aims to explore the history and origin of ‘Industrial’ diseases such as obesity, diabetes, heart disease and autism. Non-communicable, ‘Industrial’ diseases are rising at an alarming rate in Australia, and changes to the beneficial microorganisms within the human body (microbiota) may be to blame. This project will explore how human microbiota have changed over the past 100 years in response to cultural, ....Stories from the past: the impact of industrialisation on the human microbiome. This project aims to explore the history and origin of ‘Industrial’ diseases such as obesity, diabetes, heart disease and autism. Non-communicable, ‘Industrial’ diseases are rising at an alarming rate in Australia, and changes to the beneficial microorganisms within the human body (microbiota) may be to blame. This project will explore how human microbiota have changed over the past 100 years in response to cultural, environmental, and lifestyle factors linked with Industrialisation. This approach will allow stories from the past to inform modern medical treatment strategies and public health decisions in the future. The project will identify changes in environment, diet, hygiene, and medicine that have altered human microbiota in the past and sparked the Industrial disease epidemic in Australia today.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100134
Funder
Australian Research Council
Funding Amount
$160,240.00
Summary
Sydney basin multi-purpose spectral analysis facility for evolutionary and ecological studies. This near infrared spectroscopy facility at The University of New South Wales will serve the Sydney area biological research community. Near infrared spectroscopy provides quick and robust estimates of key properties of animal and plant tissues, such as age, species and chemical composition.
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less
How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative e ....How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative evolutionary and genetic approaches, the project proposes to elucidate the mechanism of pathogen blocking and ascertain its broader consequences for the host. This knowledge may be critical for maintaining the effectiveness of the biocontrol approach in the field by informing the development of resistance management strategies.Read moreRead less
Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evol ....Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL100100183
Funder
Australian Research Council
Funding Amount
$2,168,370.00
Summary
Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virule ....Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virulent strains of human, animal or plant diseases, require such evolutionary thinking. Cutting-edge mathematical tools also prepare Australians for an era in the near future where genomic data are so cheap to acquire that training in complex mathematical and logical analysis becomes a factor limiting scientific progress.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100629
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Evolutionary impacts of climate change in Australia’s fossil record. This project aims to identify evolutionary responses to climate change in Australia's fossil record by comparing variation in lizard and frog communities across geological time. Using X-ray techniques on museum specimens, this project will generate a large-scale database for tracking evolutionary shifts in relation to historical climatic events. Expected outcomes include the first anatomical descriptions for many species, filli ....Evolutionary impacts of climate change in Australia’s fossil record. This project aims to identify evolutionary responses to climate change in Australia's fossil record by comparing variation in lizard and frog communities across geological time. Using X-ray techniques on museum specimens, this project will generate a large-scale database for tracking evolutionary shifts in relation to historical climatic events. Expected outcomes include the first anatomical descriptions for many species, filling major gaps in our ability to place fossils in a contemporary framework. This research will demonstrate the value of our national collections for addressing important environmental issues, such as biodiversity, extinction, and future habitat change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100083
Funder
Australian Research Council
Funding Amount
$540,000.00
Summary
A high throughput phenomics facility for pace of life traits in animals. A high throughput phenomics facility for pace of life traits in animals: This project seeks to create the first high-throughput phenomic facility for animals in Australia. The molecular revolution has brought unprecedented capacity to understand genetic variation. Genetic variation is now better understood and more easily and cheaply characterised than the physical traits that organisms exhibit. Linking phenotypic variation ....A high throughput phenomics facility for pace of life traits in animals. A high throughput phenomics facility for pace of life traits in animals: This project seeks to create the first high-throughput phenomic facility for animals in Australia. The molecular revolution has brought unprecedented capacity to understand genetic variation. Genetic variation is now better understood and more easily and cheaply characterised than the physical traits that organisms exhibit. Linking phenotypic variation to genetic variation represents the major challenge in harnessing the power of the biomolecular age. This facility will accommodate animals from marine, freshwater and terrestrial systems across a diverse array of phyla. It will allow Australian researchers to leverage advances in high throughput genomic technologies to address a major bottleneck in biology.Read moreRead less
Drivers of phenotypic evolution in a vulnerable alpine ecosystem. This project aims to deliver a comprehensive, integrated understanding of the capacity for resilience and drivers of response of highly vulnerable alpine species and communities to climate change. The project aims to determine how communities of interacting alpine plants, soil invertebrates and microbes can cope with or evolve to novel climatic conditions. The mountains are water towers critical to power supply and Australia's agr ....Drivers of phenotypic evolution in a vulnerable alpine ecosystem. This project aims to deliver a comprehensive, integrated understanding of the capacity for resilience and drivers of response of highly vulnerable alpine species and communities to climate change. The project aims to determine how communities of interacting alpine plants, soil invertebrates and microbes can cope with or evolve to novel climatic conditions. The mountains are water towers critical to power supply and Australia's agricultural productivity. Understanding physiological tolerance and the potential for rapid evolutionary responses of plants, animals and communities is necessary to predict impacts of climate change on the future productivity of the vulnerable Australian Alps and to provide novel options for climate adaptation. Read moreRead less