Malaria: From Target Identification And Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$5,276,440.00
Summary
The team brings together a number of experts in various aspects of malaria, vaccines and drug design to develop new therapeutic approaches to control of one of the world�s major infectious diseases. Recent developments such as the complete sequence of every malaria gene provides an unparalleled opportunity to use a number of powerful new techniques in biology to identify vulnerabilities in the parasite that may be targeted. Members of the team include Professor von Itzstein who was responsible f ....The team brings together a number of experts in various aspects of malaria, vaccines and drug design to develop new therapeutic approaches to control of one of the world�s major infectious diseases. Recent developments such as the complete sequence of every malaria gene provides an unparalleled opportunity to use a number of powerful new techniques in biology to identify vulnerabilities in the parasite that may be targeted. Members of the team include Professor von Itzstein who was responsible for the design of the anti-flu drug Relenza, Professor Ross Coppel who is a pioneer in the application of molecular biology to the study of malaria, and Drs Cooke and Plebanski, exciting and talented young scientists who already have made highly significant and important contributions to our understanding of how malaria parasites function and cause disease. Success in this research program has the capacity to save millions of lives each year by preventing the deadly toll of this important human scourge.Read moreRead less
Advances In Clinical Trials Research And Evidence Based Decision Making
Funder
National Health and Medical Research Council
Funding Amount
$6,712,859.00
Summary
The NHMRC Clinical Trials Centre at the University of Sydney aims to use clinical trials and methodological research in trials to improve health in Australia and internationally It is a member of many international collaborative trials groups, especially in heart disease and cancer. A particular area of interest is patient preferences and decision making, particularly in cancer. The Clinical Trial Centre is active in using data from its own and other clinical trials in combined analyses to arriv ....The NHMRC Clinical Trials Centre at the University of Sydney aims to use clinical trials and methodological research in trials to improve health in Australia and internationally It is a member of many international collaborative trials groups, especially in heart disease and cancer. A particular area of interest is patient preferences and decision making, particularly in cancer. The Clinical Trial Centre is active in using data from its own and other clinical trials in combined analyses to arrive at better evidence.Read moreRead less
Structural Biology Of Cytokine Receptor Signalling
Funder
National Health and Medical Research Council
Funding Amount
$3,988,996.00
Summary
This Program will be focused on a group of protein hormones and their receptors, implicated in blood cell cancers and inflammatory diseases and for which current treatments are inadequate. We will determine the mechanism of receptor activation and in particular will seek to link different forms of receptor assembly to different functions. This information will help us develop new drugs with more specificity for certain hormone functions and thus less side-effects.
Tropical Infectious Diseases - Pathogenisis And Vaccine Research
Funder
National Health and Medical Research Council
Funding Amount
$7,311,989.00
Summary
The diseases on which three themes of the work proposed centre, malaria, streptococcal diseases and scabies are infectious diseases largely affecting indigenous people in various parts of the world on a massive scale, for which there are no vaccines. The aim of the work is to develop vaccines or other biological prevention measures against each of these diseases and the problems that need to be solved are similar. The team includes senior experts on thebiology of infectious diseases with long hi ....The diseases on which three themes of the work proposed centre, malaria, streptococcal diseases and scabies are infectious diseases largely affecting indigenous people in various parts of the world on a massive scale, for which there are no vaccines. The aim of the work is to develop vaccines or other biological prevention measures against each of these diseases and the problems that need to be solved are similar. The team includes senior experts on thebiology of infectious diseases with long histories of collaboration as well as younger members with impressive credentials that are new to the collaboration. The fourth theme of the work proposed is concerned with inventive new ways of making such vaccines by novelchemical methods. It has already been the subject of published collaborative work onstreptococcal disease and is equally applicable to the other themes.Read moreRead less