Rumination And Deficits In The Recall Of Positive Autobiographical Memories In Depression
Funder
National Health and Medical Research Council
Funding Amount
$263,295.00
Summary
The prevalence of depression is increasing and risk of recurrence exceeds 80%. The social and economic burden of depression highlight the urgent need to advance understanding of the habits of thought and memory that keep people feeling depressed, so that psychologists can treat depression more effectively. This project will explain why depressed people feel worse when they recall happy memories. The outcomes will extend theory and guide the improvement of treatments for this condition.
Accelerated Repetitive Transcranial Magnetic Stimulation In The Treatment Of Depression
Funder
National Health and Medical Research Council
Funding Amount
$488,098.00
Summary
rTMS is a new treatment for depression progressively being utilized in clinical practice. However, response to rTMS treatment is usually slow with treatment courses taking over 4-6 weeks. In the current study we will evaluate the efficacy of an accelerated from of rTMS administration: a course of intensive treatment being applied over a 3 day period.
A New Target For Antidepressant Treatment: Microglia Mediated Neuroinflammation
Funder
National Health and Medical Research Council
Funding Amount
$359,601.00
Summary
Depression is the leading cause of non-fatal disease burden in Australia. Unfortunately, current antidepressants do not provide adequate levels of relief and it is accepted that we need to develop more effective treatments. We have recently shown that a drug that reduces inflammation in the brain also reduces depression-like symptoms. This project aims to extend upon these extremely promising findings, in the hope of developing a new and more effective generation of antidepressants.
Developing Evidence For The Primary Prevention Of Depressive Disorders: The Role Of Diet And Physical Activity
Funder
National Health and Medical Research Council
Funding Amount
$672,136.00
Summary
This study will examine the association between diet, physical activity and depression and bipolar disorders. It will examine whether an individual's regular diet and-or levels of physical activity are related to the development and-or course of these psychiatric illnesses. There is evidence to suggest that our changing diets may play an important role in the development of mood disorders such as depression. The typical western diet has become high in saturated fats and refined sugar, while the ....This study will examine the association between diet, physical activity and depression and bipolar disorders. It will examine whether an individual's regular diet and-or levels of physical activity are related to the development and-or course of these psychiatric illnesses. There is evidence to suggest that our changing diets may play an important role in the development of mood disorders such as depression. The typical western diet has become high in saturated fats and refined sugar, while the consumption of fresh fruits and vegetables has declined, and these large-scale dietary changes may be contributing to increasing rates of depression. Moreover, there is evidence of physical activity being protective against depression, while physical inactivity is a risk factor for depression. Our lifestyles are increasingly sedentary and this may also be a contributing factor to the development of mood disorders. This study will involve women enrolled in the Geelong Osteoporosis Study (GOS), which comprises a highly representative sample of randomly-selected women from the Barwon region. The study will prospectively examine the relationships between diet and exercise and the later development of depressive disorders. To date, there is little data focusing on the role of lifestyle factors in the development of depressive disorders. This study will contribute comprehensive information regarding modifiable lifestyle factors that play a role in the development of these disorders. This data can be incorporated with information regarding other modifiable risk factors, such as drug and alcohol misuse, to create a simple public health message on how to reduce one's risk of developing these disorders. A preventative approach to mental illness would be cost-effective and able to be implemented at a population level. It is likely to lead to better outcomes for those affected by depressive illnesses and reduce the public health burden of psychiatric illness in Australia.Read moreRead less
The Efficacy Of N-acetylcysteine As An Adjunctive Treatment In Bipolar Depression: A Double-blind, Randomised, Placebo-controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$970,090.00
Summary
The brain's antioxidant defences, particularly glutathione, are reduced in bipolar disorder. Treatment with N-acetylcysteine (NAC), a naturally occurring and well-tolerated glutathione precursor, has been shown by our research group to be effective at reducing depression in people with bipolar disorder during a 6-month pilot trial. In this definitive placebo controlled randomised study, we aim to see if add-on treatment with NAC can reduce depression in participants in the depressive phase of bi ....The brain's antioxidant defences, particularly glutathione, are reduced in bipolar disorder. Treatment with N-acetylcysteine (NAC), a naturally occurring and well-tolerated glutathione precursor, has been shown by our research group to be effective at reducing depression in people with bipolar disorder during a 6-month pilot trial. In this definitive placebo controlled randomised study, we aim to see if add-on treatment with NAC can reduce depression in participants in the depressive phase of bipolar disorder.Read moreRead less
Multivariate Whole Genome Estimation And Prediction Analysis Of Genomics Data Applied To Psychiatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$639,582.00
Summary
We have made major contributions to the development of statistical methods applied to data from the international Psychiatric Genomics Consortium. Major new data sets will soon become available, with immense sample sizes (100,000s) and more extensive clinical and environmental data. We will develop and apply novel statistical analyses of these data, to answer fundamental questions about the genetic basis of psychiatric disorders and the interplay of genetic and environmental risk factors.
Inflammatory Cytokines As Risk Factors For The Development Of Both Depression And Osteoporosis In Men
Funder
National Health and Medical Research Council
Funding Amount
$381,091.00
Summary
Both depression and osteoporosis impose a substantial public health burden on society and there is now research to suggest that these conditions are related. This study will examine a potential common mechanism, systemic inflammation, which may underlie both diseases. It will focus on markers of systemic inflammation, examine their association to both depression and bone fragility and determine what role they play in explaining the relationship between the disorders.
Defining The Function Of Two Discrete Precursor Cell Populations In The Adult Hippocampus: Potential For The Treatment Of Cognitive And Mood Disorders
Funder
National Health and Medical Research Council
Funding Amount
$578,985.00
Summary
Adult hippocampal neurogenesis plays a crucial role in fundamental cognitive processes such as learning and memory formation and mood regulation. Our laboratory has identified two discrete pools of quiescent stem and precursor cells in the adult hippocampus that can be activated by distinct mechanisms. This study will examine the functional properties of new neurons generated from these discrete pools and their role in improving behavioural outcomes associated with cognition and mood regulation
Clinical And Neurobiological Predictors Of Onset Of Major Mental Disorders (mania, Psychosis, Severe Depression), And Associated Functional Impairment, In Adolescent And Young Adult Twins: A Prospective Longitudinal Study
Funder
National Health and Medical Research Council
Funding Amount
$1,356,103.00
Summary
The Brisbane Twin Study is a prospective twin study tracking the real-time developmental trajectories of the onset of anxiety, mood, psychotic or substance misuse disorders through adolescence and young adulthood. This unique study has now reached the point where reassessment (after 20 years) can be performed. We will now determine the extent to which outcomes are predicted by neurobiological and genetic markers. This information is critical to prevention or early intervention strategies.
A Breakdown Of Cortical Homeostasis In Depression: A Focus On The Anterior Cingulate
Funder
National Health and Medical Research Council
Funding Amount
$625,629.00
Summary
Major depressive disorders affect 20% of the Australian population. Some symptoms of major depressive disorders arise because of a dysfunction of the human brain, particularly the cortex. Our studies show there are biochemical changes in the anterior cingulate cortex in people with mood disorders. We will now extend our studies to show there is a breakdown in the balance between neurotransmitter and neuroinflammation pathways in the anterior cingulate cortex in major depressive disorders.