Development Of Antimicrobial Peptides Targeting Oral Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$663,350.00
Summary
The bacterial associated oral diseases; periodontitis and caries are major public health problems. The prevalence of these diseases and increasing bacterial antibiotic resistance has meant there is a need to develop new therapies. This project addresses this by modifying a novel class of antibiotics/antiseptics �antimicrobial peptides� to target oral bacteria and testing them using a newly developed screening method. This project will lead to new therapies for periodontitis and caries.
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101210
Funder
Australian Research Council
Funding Amount
$431,476.00
Summary
Social Inequalities in Oral Health among Australian Working Age Adults. Australian working age adults with social and economic disadvantage have significantly poorer oral health outcomes than those from advantaged backgrounds. This project explores how changes in social position over time, and interactions between different forms of social disadvantage, contribute to social inequalities in oral health. This project expects to improve understanding of social inequalities in oral health, and its s ....Social Inequalities in Oral Health among Australian Working Age Adults. Australian working age adults with social and economic disadvantage have significantly poorer oral health outcomes than those from advantaged backgrounds. This project explores how changes in social position over time, and interactions between different forms of social disadvantage, contribute to social inequalities in oral health. This project expects to improve understanding of social inequalities in oral health, and its solutions, by developing and applying analytical and simulation models. This will help identify ways to reduce the persistent social inequalities in oral health outcomes in working age adults. In doing this, it will inform policies in future that will significantly improve the well-being of Australian working age adults.Read moreRead less
Population Health Planning For Rural Medicare Locals: Evaluating A Community Participation Method For Delivering Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$438,587.00
Summary
The study, in six communities, will evaluate whether an evidenced based method of rural community participation from the UK translates to assist healthcare planning by Medicare Locals. Medicare Locals must involve local people in designing services to improve health, but lack methods to do this. The focus of the study is oral health, a major issue in rural areas. The study evaluates whether new services are designed and implemented and whether there is change to health knowledge and behaviours.
Flowable composite system with short S-glass fibre and halloysite nanotubes. Flowable composite system with short S-glass fibre and halloysite nanotubes. This project aims to design dental materials with reduced amalgams, using a strong but flowable composite with randomly distributed short S-glass fibres and a non-toxic natural nano-composite overlay. This alternative dental composite material is expected to meet international regulatory bodies’ intention to reduce amalgams. Using advanced phot ....Flowable composite system with short S-glass fibre and halloysite nanotubes. Flowable composite system with short S-glass fibre and halloysite nanotubes. This project aims to design dental materials with reduced amalgams, using a strong but flowable composite with randomly distributed short S-glass fibres and a non-toxic natural nano-composite overlay. This alternative dental composite material is expected to meet international regulatory bodies’ intention to reduce amalgams. Using advanced photonic and micro-mechanical techniques to make engineered material is also expected to enhance Australian manufacturing.Read moreRead less
Teeth tales: A culturally competent community intervention for child oral health in low SES area of urban Melbourne. Dental caries represent the highest burden of disease for pre-school children. Disadvantaged, refugee and migrant communities face an estimated increased prevalence of 60%. Community-based health solutions that are evidence based and cross-sectoral are urgently needed. The potential impact of improved child oral health on social, emotional and learning outcomes is compelling. The ....Teeth tales: A culturally competent community intervention for child oral health in low SES area of urban Melbourne. Dental caries represent the highest burden of disease for pre-school children. Disadvantaged, refugee and migrant communities face an estimated increased prevalence of 60%. Community-based health solutions that are evidence based and cross-sectoral are urgently needed. The potential impact of improved child oral health on social, emotional and learning outcomes is compelling. The child health and service change outcomes of this study will be of direct benefit to the community and will have clear applications for other culturally diverse local government areas in Australia and other developed countries. The findings will directly inform policy/funding decision making by Dental Health Services Victoria for Victorian families and services.Read moreRead less
Social practices of oral health in Australian preschool children. The aim of the study is to explore "social practices" of oral health in Australian (Aboriginal and non-Aboriginal) preschool children. We use this emerging theory to move away from focusing on individuals and individual behaviour (and blame) to identify and map social practices: actions, materials and meanings families attribute to
child’s oral health. Expected project outcomes include identifying practices promoting or underminin ....Social practices of oral health in Australian preschool children. The aim of the study is to explore "social practices" of oral health in Australian (Aboriginal and non-Aboriginal) preschool children. We use this emerging theory to move away from focusing on individuals and individual behaviour (and blame) to identify and map social practices: actions, materials and meanings families attribute to
child’s oral health. Expected project outcomes include identifying practices promoting or undermining children’s oral health that can inform upstream and downstream policy directions and practices to improve health outcomes. This offers a new approach to "wicked" problems such as oral health where extensive
effort has not reduced morbidity and cost despite rhetoric that oral health is preventable.Read moreRead less
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less