Development Of Antimicrobial Peptides Targeting Oral Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$663,350.00
Summary
The bacterial associated oral diseases; periodontitis and caries are major public health problems. The prevalence of these diseases and increasing bacterial antibiotic resistance has meant there is a need to develop new therapies. This project addresses this by modifying a novel class of antibiotics/antiseptics �antimicrobial peptides� to target oral bacteria and testing them using a newly developed screening method. This project will lead to new therapies for periodontitis and caries.
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
Population Health Planning For Rural Medicare Locals: Evaluating A Community Participation Method For Delivering Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$438,587.00
Summary
The study, in six communities, will evaluate whether an evidenced based method of rural community participation from the UK translates to assist healthcare planning by Medicare Locals. Medicare Locals must involve local people in designing services to improve health, but lack methods to do this. The focus of the study is oral health, a major issue in rural areas. The study evaluates whether new services are designed and implemented and whether there is change to health knowledge and behaviours.
Flowable composite system with short S-glass fibre and halloysite nanotubes. Flowable composite system with short S-glass fibre and halloysite nanotubes. This project aims to design dental materials with reduced amalgams, using a strong but flowable composite with randomly distributed short S-glass fibres and a non-toxic natural nano-composite overlay. This alternative dental composite material is expected to meet international regulatory bodies’ intention to reduce amalgams. Using advanced phot ....Flowable composite system with short S-glass fibre and halloysite nanotubes. Flowable composite system with short S-glass fibre and halloysite nanotubes. This project aims to design dental materials with reduced amalgams, using a strong but flowable composite with randomly distributed short S-glass fibres and a non-toxic natural nano-composite overlay. This alternative dental composite material is expected to meet international regulatory bodies’ intention to reduce amalgams. Using advanced photonic and micro-mechanical techniques to make engineered material is also expected to enhance Australian manufacturing.Read moreRead less
Teeth tales: A culturally competent community intervention for child oral health in low SES area of urban Melbourne. Dental caries represent the highest burden of disease for pre-school children. Disadvantaged, refugee and migrant communities face an estimated increased prevalence of 60%. Community-based health solutions that are evidence based and cross-sectoral are urgently needed. The potential impact of improved child oral health on social, emotional and learning outcomes is compelling. The ....Teeth tales: A culturally competent community intervention for child oral health in low SES area of urban Melbourne. Dental caries represent the highest burden of disease for pre-school children. Disadvantaged, refugee and migrant communities face an estimated increased prevalence of 60%. Community-based health solutions that are evidence based and cross-sectoral are urgently needed. The potential impact of improved child oral health on social, emotional and learning outcomes is compelling. The child health and service change outcomes of this study will be of direct benefit to the community and will have clear applications for other culturally diverse local government areas in Australia and other developed countries. The findings will directly inform policy/funding decision making by Dental Health Services Victoria for Victorian families and services.Read moreRead less
Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, ....Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement. This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.Read moreRead less
Delivering Next-Generation Broadband Internet Access to Australia: Integration of Broadband Optical and Wireless Networks. Provision of broadband services is a high priority for the Australian government as evidenced by a range of initiatives costing more than $4 billion. Especially, the integration of optical and wireless broadband access will potentially provide inexpensive and efficient solutions to customers. Building on the strength of existing photonics and wireless industries in Australia ....Delivering Next-Generation Broadband Internet Access to Australia: Integration of Broadband Optical and Wireless Networks. Provision of broadband services is a high priority for the Australian government as evidenced by a range of initiatives costing more than $4 billion. Especially, the integration of optical and wireless broadband access will potentially provide inexpensive and efficient solutions to customers. Building on the strength of existing photonics and wireless industries in Australia, direct and indirect outcomes of this project can lead to new business opportunities and will further strengthen the growing local telecommunication industries. It is also anticipated that national and international collaboration will generate further research activities and significantly enhance the existing reputation of Australian research capabilities.Read moreRead less
Enhancing Australian Universities' Research Commercialisation Performance. The primary aims of the project are to develop a detailed understanding of the systematic barriers to research commercialisation within Australian universities and to promote innovation within the commercialisation through the adoption of effective processes. The project will also explore the needs of the smaller and regional universities to develop effective strategies that will enhance their research commercialisation c ....Enhancing Australian Universities' Research Commercialisation Performance. The primary aims of the project are to develop a detailed understanding of the systematic barriers to research commercialisation within Australian universities and to promote innovation within the commercialisation through the adoption of effective processes. The project will also explore the needs of the smaller and regional universities to develop effective strategies that will enhance their research commercialisation capacity and performance through the promotion of industry uptake of their research outcomes.Read moreRead less