Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
Discovery Early Career Researcher Award - Grant ID: DE170101406
Funder
Australian Research Council
Funding Amount
$352,019.00
Summary
Using anthropology of finance to study disaster relief. This project aims to broaden and re-theorise economic definitions of insurance through ethnographic methodologies and feminist studies of finance. Using responses to weather disasters and the financial products created to cover them, the project will explore cultural understandings of protection and damage through a Latin American case that foregrounds experimental and emerging adaptation. In doing so, the research expects to open new direc ....Using anthropology of finance to study disaster relief. This project aims to broaden and re-theorise economic definitions of insurance through ethnographic methodologies and feminist studies of finance. Using responses to weather disasters and the financial products created to cover them, the project will explore cultural understandings of protection and damage through a Latin American case that foregrounds experimental and emerging adaptation. In doing so, the research expects to open new directions in the anthropological study of poverty and contemporary capitalism, and provide working frameworks to understand how financial services can engage meaningfully with communities affected by ever more uncertain weather. This potentially benefits communities managing disaster relief, evidence-based policy development, and public understanding of social and economic protection.Read moreRead less
Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100174
Funder
Australian Research Council
Funding Amount
$805,000.00
Summary
Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smar ....Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smart, productive and resilient cities. These capabilities are predicated on the adoption of ISO standards, development of new ontological frameworks and an urban data dictionary to enable semantic inferencing of datasets and the development of data structures and services. This framework would then be applied to data relevant to people, land and urban infrastructure to support comparative and multi-dimensional analytics. Read moreRead less
A New Phase and New Issues of Rural-Urban Migration in China. China’s urbanisation has come to a turning point. The large pool of rural young workers (16-25 years of age), which fed the industrialisation needs of the 1990s and 2000s, has exhausted. Future growth needs to rely on the increase in the length of stay of the existing migrants and the increase in older new migrants. Due to this shift, the institutional restrictions, which deter family migration, become the key challenge. This project ....A New Phase and New Issues of Rural-Urban Migration in China. China’s urbanisation has come to a turning point. The large pool of rural young workers (16-25 years of age), which fed the industrialisation needs of the 1990s and 2000s, has exhausted. Future growth needs to rely on the increase in the length of stay of the existing migrants and the increase in older new migrants. Due to this shift, the institutional restrictions, which deter family migration, become the key challenge. This project examines the cost of the migration restrictions (shortened labour supply and reduced human capital accumulation for the current and next generation migrants: their education, health and pro-social behaviour); and the best way to reform the restrictions on family migration and the priority for the reform.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100118
Funder
Australian Research Council
Funding Amount
$1,800,000.00
Summary
UltraTEM: Resolving the structure of matter in space, energy and time. This project aims to establish a transmission electron microscope facility to analyse materials structure at the atomic level. A small number of atoms in critical locations governs the properties of materials from solar cells and catalysts to aerospace alloys, bio-sensors and quantum computers. To understand and engineer matter at this atomic level, tools are needed to characterise these critical atoms. This open access, nati ....UltraTEM: Resolving the structure of matter in space, energy and time. This project aims to establish a transmission electron microscope facility to analyse materials structure at the atomic level. A small number of atoms in critical locations governs the properties of materials from solar cells and catalysts to aerospace alloys, bio-sensors and quantum computers. To understand and engineer matter at this atomic level, tools are needed to characterise these critical atoms. This open access, national facility will be able to characterise matter at the atomic-level. Expected outcomes include better understanding of the natural world and advanced materials to solve problems in energy, technology, health, environment, communications, advanced manufacturing, transport and security.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100132
Funder
Australian Research Council
Funding Amount
$1,486,000.00
Summary
A triple beam microscope: new frontiers in materials nanocharacterisation. This project aims to establish a triple beam ion and electron microscope facility for the modification, preparation and characterisation of materials that have hitherto been too sensitive for high resolution analysis with charged particle beams. It is expected that materials will be studied artefact-free and at the nanoscale with twin ion beams and new detectors that allow novel imaging modes and extreme chemical sensitiv ....A triple beam microscope: new frontiers in materials nanocharacterisation. This project aims to establish a triple beam ion and electron microscope facility for the modification, preparation and characterisation of materials that have hitherto been too sensitive for high resolution analysis with charged particle beams. It is expected that materials will be studied artefact-free and at the nanoscale with twin ion beams and new detectors that allow novel imaging modes and extreme chemical sensitivity plus controlled atmosphere transfer to other instruments for correlative measurements. This unique facility should benefit research in many disciplines such as physics, chemistry, geology, pharmacy, materials, civil and chemical engineering by allowing first-ever observations of vital phenomena in diverse materials.Read moreRead less
Multi-object Estimation for Live-Cell Microscopy. The objective of this project is to develop new tools for the inference of biological information from live-cell data to facilitate analysis of experiments and speed up discovery in cell biology. The new tools would provide reliable, consistent inference requiring no manual intervention and able to process large volumes of data in a timely manner. This would equip biologists with a vehicle that could move them closer to the goal of understanding ....Multi-object Estimation for Live-Cell Microscopy. The objective of this project is to develop new tools for the inference of biological information from live-cell data to facilitate analysis of experiments and speed up discovery in cell biology. The new tools would provide reliable, consistent inference requiring no manual intervention and able to process large volumes of data in a timely manner. This would equip biologists with a vehicle that could move them closer to the goal of understanding the mechanism behind biological processes.Read moreRead less
Epigenetic reprogramming of development by nutritional factors in honeybee. The project aims to study the mechanism by which a specialised nutrition can change or even reverse the process of adult cell fate. The project will use a previously unexplored method of nutritional reprogramming of imaginal discs in honeybees by royal jelly and identify novel components of both the genetic and epigenetic systems that are most potent as reprogramming factors. The project seeks to improve our understandin ....Epigenetic reprogramming of development by nutritional factors in honeybee. The project aims to study the mechanism by which a specialised nutrition can change or even reverse the process of adult cell fate. The project will use a previously unexplored method of nutritional reprogramming of imaginal discs in honeybees by royal jelly and identify novel components of both the genetic and epigenetic systems that are most potent as reprogramming factors. The project seeks to improve our understanding of how epigenetic remodelling of the information content of the genome contributes to conversion of cell fate in vivo and in vitro. More broadly, the project could potentially establish the honeybee imaginal discs as a model for understanding pluripotency and environmentally controlled developmental plasticity.Read moreRead less
What is safe about “safe migration”? Migration management in the Mekong. The project seeks to examine the claims that new policy models make about assuring the safety of labour migrants. What is safe about safe migration? Regulation of labour migrants is a central policy concern in Asia, Australia and elsewhere. In an attempt to address anti-trafficking, several donors, United Nations agencies, nongovernment organisations and Governments have launched ‘safe migration’ programs which, rather than ....What is safe about “safe migration”? Migration management in the Mekong. The project seeks to examine the claims that new policy models make about assuring the safety of labour migrants. What is safe about safe migration? Regulation of labour migrants is a central policy concern in Asia, Australia and elsewhere. In an attempt to address anti-trafficking, several donors, United Nations agencies, nongovernment organisations and Governments have launched ‘safe migration’ programs which, rather than focusing solely on the legal status of migrants, seek to develop mechanisms (eg hotline numbers) to assure their safety. This research examines the claims of safety that this shift from anti-trafficking to safe migration has engendered, and whether and in what terms labour migrants might be consequently safer’. Project results may inform aid programs and government policies.Read moreRead less