A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less
Optimised distributed stimulation of muscle. The project aims to extend to humans, a method of producing a non-fatiguing, smooth, submaximal muscle contraction. The method using multiple electrodes, stimulated at different times, with those times being adjusted for optimum smoothness at low stimulation rates. This will enable the gathering of information about the mechanics of muscle undergoing near physiological contractions, which will be of interest to researchers in Biomechanics. It will ....Optimised distributed stimulation of muscle. The project aims to extend to humans, a method of producing a non-fatiguing, smooth, submaximal muscle contraction. The method using multiple electrodes, stimulated at different times, with those times being adjusted for optimum smoothness at low stimulation rates. This will enable the gathering of information about the mechanics of muscle undergoing near physiological contractions, which will be of interest to researchers in Biomechanics. It will also be a step towards the restoration of function to spinal cord injured patients.Read moreRead less
Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth res ....Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth research of vascular diseases but also provide a virtual forecasting tool for physicians or surgeons to develop guidance on diagnosis and therapeutic planning of clinical treatment, which brings great socio-economic benefit to the health of the Australian community.Read moreRead less