How Does The Tumour Suppressor: Nerfin-1 Prevent Dietary Dependent Tumour Growth?
Funder
National Health and Medical Research Council
Funding Amount
$630,942.00
Summary
The influence of diet has been linked to tumour growth for decades, however, there is little scientific evidence to support or disprove this. In this study, we will assess the effect of diet on tumours in fruit flies. The metabolic genes which regulate the growth of fly tumours will then be studied in human brain tumours. Our studies will ultimately shed light on how tissue growth is controlled by dietary intake, and have the potential to inform the way that we treat and manage human cancers.
Functional Studies On The Role Of DNp73 In Stem Cells And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$428,838.00
Summary
This project investigates the role of the p73 gene in regulating stem cells and facilitating intestinal cancer formation. We hypothesize that when a particular form of this gene (DNp73) is upregulated it prevents differentiation of stem cells and promotes tumour formation. We combine novel approaches in mice and fruit flies to examine the function of DNp73 in stem cells with analysis of human tumour samples. These studies may identify a new target for tumour therapy.