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Development Of DNA Targeted Platinum Agents As Potential Anticancer Drugs
Funder
National Health and Medical Research Council
Funding Amount
$410,250.00
Summary
A number of clinically useful anticancer drugs damage DNA. As a result of this damage these drugs kill cancer cells. This project aims to develop new platinum-containing compounds which are specifically targeted to DNA. Through this strategy it is possible that new and more useful anticancer drugs could emerge.
Genes Encoding The Epithelial Sodium Channel Subunits And Blood Pressure
Funder
National Health and Medical Research Council
Funding Amount
$429,330.00
Summary
High blood pressure is a prominent risk factor for heart attack and stroke which kill over 30,000 Australians each year. Blood pressure is determined by the combination of inherited predisposition and lifestyle factors such as diet. Understanding these combinations offers new opportunities for preventing or treating high blood pressure and reducing the incidence of cardiovascular disease. As part of an NHMRC-funded project, we have discovered recently that genes controlling the amount of salt ex ....High blood pressure is a prominent risk factor for heart attack and stroke which kill over 30,000 Australians each year. Blood pressure is determined by the combination of inherited predisposition and lifestyle factors such as diet. Understanding these combinations offers new opportunities for preventing or treating high blood pressure and reducing the incidence of cardiovascular disease. As part of an NHMRC-funded project, we have discovered recently that genes controlling the amount of salt excreted by the kidneys appear to be linked with high blood pressure. If confirmed, this observation might provide an explanation of salt on blood pressure in susceptible individuals. Building on our basic observation, we shall extend our studies to place the findings beyond reasonable doubt. We shall investigate the gene sequences to discover what changes might lead to high blood pressure and examine how these affect the kidney and body salt. These studies combine forces of two large international blood pressure research groups. Our observation is the first internationally to define a blood pressure gene in the general community. Our results are potentially relevant to many more people than only those with very high blood pressure.Read moreRead less
Assessment Of Mismatch Repair Gene Sequence Variants For Clinical Relevance
Funder
National Health and Medical Research Council
Funding Amount
$472,659.00
Summary
Mutations in mismatch repair genes cause familial cancer. A number of families carry sequence changes that do not obviously alter the gene product, and it is difficult to predict whether these variants are the direct cause of cancer in the family. Consequently, it is not possible to offer informative genetic counselling to these families. We aim to assess the value of several web-based programs, with additional information, to predict the functional changes determined for a panel of variants.