Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100021
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Australian Cultural Data Engine for Research, Industry and Government. The project aims to develop an Australian Cultural Data Engine (ACD-Engine), which will be an open software engineering facility that interacts with leading existing cultural databases in architecture, visual and performing arts, humanities, and heritage to build a bridge to information and social sciences. The ACD-Engine will unify and expand these disparate and previously unconnected systems to allow advanced analysis techn ....Australian Cultural Data Engine for Research, Industry and Government. The project aims to develop an Australian Cultural Data Engine (ACD-Engine), which will be an open software engineering facility that interacts with leading existing cultural databases in architecture, visual and performing arts, humanities, and heritage to build a bridge to information and social sciences. The ACD-Engine will unify and expand these disparate and previously unconnected systems to allow advanced analysis techniques to be performed. It will deliver innovative and searchable formats that ensure interoperability, improved search, interactive design and interpretation aids that will benefit the policy and planning for national and international alignments between researchers, industry and government.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100017
Funder
Australian Research Council
Funding Amount
$1,231,000.00
Summary
Networked knowledge for repatriation communities. This project aims to build a digital facility that supports the repatriation of Indigenous human remains. Repatriation contributes to reconciliation and Indigenous healing and wellbeing, and has been the most important agent of change in the relationship between Indigenous peoples, museums and the academy over the past 40 years. Successful repatriation requires and produces research materials diverse in type, geography and accessibility. Within a ....Networked knowledge for repatriation communities. This project aims to build a digital facility that supports the repatriation of Indigenous human remains. Repatriation contributes to reconciliation and Indigenous healing and wellbeing, and has been the most important agent of change in the relationship between Indigenous peoples, museums and the academy over the past 40 years. Successful repatriation requires and produces research materials diverse in type, geography and accessibility. Within an Indigenous data-governance framework, this project will gather, preserve and make accessible a critical and extensive record of repatriation information worldwide. The project is expected to support repatriation practice and scholarship and improve the opportunities of repatriation for social good.Read moreRead less