The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
How Replication Stress Activates The Mitotic Telomere DNA Damage Response To Kill Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$486,467.00
Summary
We discovered a novel mechanism linking stress during DNA replication to difficulties with the cell division process, and identified how this turns on DNA damage response signals from the chromosome ends (i.e. “telomeres”). We have further identified that we can exploit this mechanism to kill cancer cells. In this project we will explore this newly discovered mechanism and identify how it can be targeted for therapeutic purposes.
Suharto's enablers? Social complicity in the Indonesian killings of 1965-66. This projects aims to revolutionise understandings of civilian involvement in the most critical and bloody turning point in modern Indonesian history, the 1965-66 killings, and to transform the evidence base for Indonesian history-writing. By accessing critically endangered and never before used survivor community archives, the project will examine the complicity of civilians in the killings and how the violence shaped ....Suharto's enablers? Social complicity in the Indonesian killings of 1965-66. This projects aims to revolutionise understandings of civilian involvement in the most critical and bloody turning point in modern Indonesian history, the 1965-66 killings, and to transform the evidence base for Indonesian history-writing. By accessing critically endangered and never before used survivor community archives, the project will examine the complicity of civilians in the killings and how the violence shaped modern Indonesian national identity and moral consciousness. It will further generate a new, centralised archive of these preserved materials and compile new oral history interviews with the remaining witnesses to these pivotal events.Read moreRead less
The Western Australia New Music Archive: 1970 - today: finding, accessing, remembering, performing. This project sees the creation of the Western Australian New Music Archive, a digital repository of and interface to Western Australian music composed from 1970 to the present day. A partnership between peak state and national bodies, the project will also involve the performance and recording of works from the archive.
Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
Epigenetic Changes In The Prostate Cancer Microenvironment
Funder
National Health and Medical Research Council
Funding Amount
$848,954.00
Summary
Many men with prostate cancer have slow-growing tumours that are unlikely to spread outside the prostate. These men with low-risk cancer are often monitored to prevent unnecessary aggressive treatments. However, the current methods used to distinguish between slow-growing and aggressive tumours are imprecise and there is a risk of missing aggressive tumours. We aim to identify new biomarkers of prostate cancer by measuring modifications to the DNA in the tumour and surrounding cells
Circulating Tumour DNA To Monitor Treatment Response And Resistance In Chronic Lymphocytic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$876,950.00
Summary
Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if ctDNA can be used to monitor treatment responses and individualise treatment decisions in patients with chronic lymphocytic leukaemia.
Ancient Egyptian papyri: unlocking secrets to the history of writing. This project aims to investigate the chemical composition of papyri from ancient Egypt and their inks to identify scribes, date texts, detect forgeries, match fragmentary texts, and illuminate environmental and technological change. Papyrus and carbon-based ink were the primary writing materials in the ancient Mediterranean world from 2600 BCE to 1000 CE, but the uncertain provenance and date caused by clandestine excavation a ....Ancient Egyptian papyri: unlocking secrets to the history of writing. This project aims to investigate the chemical composition of papyri from ancient Egypt and their inks to identify scribes, date texts, detect forgeries, match fragmentary texts, and illuminate environmental and technological change. Papyrus and carbon-based ink were the primary writing materials in the ancient Mediterranean world from 2600 BCE to 1000 CE, but the uncertain provenance and date caused by clandestine excavation and the antiquities trade limits our understanding of them. The non-destructive and inexpensive analysis will provide new understanding of environmental, technological, and socio-cultural change in ancient cultures from Egypt to Rome by providing new insights into writing technology, scribal identity, dating, and authenticity.Read moreRead less
Howitt & Fison’s anthropology. Howitt & Fison’s anthropology. This project will systematically analyse nineteenth century anthropologists Lorimer Fison and A.W. Howitt’s accounts of Indigenous kinship, social organisation, and local languages, and historical encounters between settlers and Indigenous people. This project will assemble Fison and Howitt’s meticulous records into best-practice digital formats, with widely accessible interactive data presentation, and bring these extraordinary recor ....Howitt & Fison’s anthropology. Howitt & Fison’s anthropology. This project will systematically analyse nineteenth century anthropologists Lorimer Fison and A.W. Howitt’s accounts of Indigenous kinship, social organisation, and local languages, and historical encounters between settlers and Indigenous people. This project will assemble Fison and Howitt’s meticulous records into best-practice digital formats, with widely accessible interactive data presentation, and bring these extraordinary records to the broadest possible community. This research, which integrates anthropology, history and linguistics, is expected to open up new dimensions in Australian history, anthropological theory, and Australian linguistics.Read moreRead less