Using integrated frontier and smart technologies to identify new drug targets for parasites causing major diseases in humans and animals. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of anti-parasite compounds and/or vaccines; (2) improved and sustainable control of important parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a ....Using integrated frontier and smart technologies to identify new drug targets for parasites causing major diseases in humans and animals. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of anti-parasite compounds and/or vaccines; (2) improved and sustainable control of important parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a technology platform for further applications in genomics and post-genomics of pathogens of global significance and construction of a pipeline for the validation of drug targets; (5) capturing the benefits from fundamental research and strengthening links between fundamental and applied research; (6) increasing the quality and quantity of scientifically skilled people in biotechnology.Read moreRead less
Automated, smart genomic data integration for the exploration of developmentally regulated molecules in parasites of major socioeconomic importance. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of safe anti-parasite compounds/vaccines; (2) improved and sustainable control of key parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation o ....Automated, smart genomic data integration for the exploration of developmentally regulated molecules in parasites of major socioeconomic importance. The national/community benefits are (1) enhanced focus on animal and human health biotechnology through the development of safe anti-parasite compounds/vaccines; (2) improved and sustainable control of key parasites with decreased risk of induction of drug resistance; (3) increased profitability of agricultural animal production; (4) consolidation of a technology platform for further applications in genomics and post-genomics of pathogens of global significance and construction of a pipeline for the validation of drug targets; (5) capturing the benefits from fundamental research and strengthening links between fundamental and applied research; (6) increasing the quality and quantity of scientifically skilled people in biotechnology.Read moreRead less
Regulation of the EphA3 receptor tyrosine kinase in vertebrate development. The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge ma ....Regulation of the EphA3 receptor tyrosine kinase in vertebrate development. The Eph/ephrin system has a critical role in normal embryonic development. Amongst vertebrates, the EphA3 gene is one of the most highly conserved genes in this system with critical roles in development of the visual system and in other developmental processes. Understanding how this gene is regulated will help us to understand the critical role of EphA3 in the basic biology of humans and other animals. This knowledge may also shed light on the basis of congenital abnormalities and other pathological processes and possibly help us to understand how to prevent or treat these conditions.Read moreRead less
Tissue specific regulation of gene expression. Despite the polarized public debate concerning the use of stem cells for tissue regeneration, fundamental questions relating to the identity and hierarchy of these cells remain unanswered. The benefit to Australia will be scientific in terms of providing an understanding of how stem and progenitor cells integrate transcriptional control systems during differentiation and the networks that are involved. This is fundamental to the future isolation a ....Tissue specific regulation of gene expression. Despite the polarized public debate concerning the use of stem cells for tissue regeneration, fundamental questions relating to the identity and hierarchy of these cells remain unanswered. The benefit to Australia will be scientific in terms of providing an understanding of how stem and progenitor cells integrate transcriptional control systems during differentiation and the networks that are involved. This is fundamental to the future isolation and manipulation of these stem cell types to benefit the community. The work will also provide postgraduate students with training in state of the art genomic techniques and in the interface between bioinformatics and experimental science. Read moreRead less