Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledg ....Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users. Read moreRead less
Bridging the gap between global mechanics and regional imaging in the lungs. The detailed mechanics of breathing are not well understood, due to a lack of regional lung measurement techniques. This project aims to develop a powerful analysis tool to image in vivo mechanical properties of the lungs. The expected outcome of this project is a novel platform for investigation and understanding of lung function, enabling information previously only available for the whole lung to be calculated for lo ....Bridging the gap between global mechanics and regional imaging in the lungs. The detailed mechanics of breathing are not well understood, due to a lack of regional lung measurement techniques. This project aims to develop a powerful analysis tool to image in vivo mechanical properties of the lungs. The expected outcome of this project is a novel platform for investigation and understanding of lung function, enabling information previously only available for the whole lung to be calculated for local lung regions within the body. The image analysis methods developed are intended to enable respiratory researchers to investigate lung function in unprecedented detail, leading to new insights into the workings of this complicated and vital organ. Read moreRead less