Wolbachia endosymbionts: novel strain dynamics in Australian Drosophila. This project aims to understand Wolbachia infections across Australian Drosophila flies. Wolbachia bacteria that live inside the cells of insects and other invertebrates are widely seen as a promising tool for pest and disease control. This project will assess the population distribution, host phenotypic effects, population dynamics and evolutionary context of multiple Wolbachia infections across Australian Drosophila flies ....Wolbachia endosymbionts: novel strain dynamics in Australian Drosophila. This project aims to understand Wolbachia infections across Australian Drosophila flies. Wolbachia bacteria that live inside the cells of insects and other invertebrates are widely seen as a promising tool for pest and disease control. This project will assess the population distribution, host phenotypic effects, population dynamics and evolutionary context of multiple Wolbachia infections across Australian Drosophila flies. The outcome will include new and novel strains for applied projects, new information on the fate of Wolbachia infections, and new insights into the factors that dictate the fate of Wolbachia infections across populations.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100022
Funder
Australian Research Council
Funding Amount
$3,402,903.00
Summary
Redefining virus ecology and evolution. This project aims to employ novel genomic analyses of viruses from Australian fauna to resolve major questions in RNA virus ecology and evolution, and is expected to reveal the basic processes that shape the virosphere, determine how viruses jump species to emerge and cause disease in new hosts, and how viruses evolve new levels of virulence. The research will provide a new understanding of how viruses evolve and contribute to global ecosystems and develop ....Redefining virus ecology and evolution. This project aims to employ novel genomic analyses of viruses from Australian fauna to resolve major questions in RNA virus ecology and evolution, and is expected to reveal the basic processes that shape the virosphere, determine how viruses jump species to emerge and cause disease in new hosts, and how viruses evolve new levels of virulence. The research will provide a new understanding of how viruses evolve and contribute to global ecosystems and develop new bioinformatics tools to identify and analyse highly divergent genome sequences through studying meta-transcriptomic data from diverse animal phyla, from prokaryotes and basal eukaryotes, from iconic native mammalian species and their major invasive pests. The benefits provided will include determining the viromes of native and invasive species and enhancing the efforts to protect iconic Australian species from infectious disease.Read moreRead less
Bacterial vesicles transport their bioactive cargo to the host nucleus. This project aims to investigate how bacterial membrane vesicles transport their cargo to the nucleus of cells and its impact on host cell functions. Bacteria use membrane vesicles as a means of communication with the host, but the full extent of their effects on host cells has yet to be fully elucidated. This project expects to generate new knowledge in the field using cutting-edge imaging and molecular biology approaches. ....Bacterial vesicles transport their bioactive cargo to the host nucleus. This project aims to investigate how bacterial membrane vesicles transport their cargo to the nucleus of cells and its impact on host cell functions. Bacteria use membrane vesicles as a means of communication with the host, but the full extent of their effects on host cells has yet to be fully elucidated. This project expects to generate new knowledge in the field using cutting-edge imaging and molecular biology approaches. The work should provide significant benefits, particularly towards the development of membrane vesicles in gene therapy, gene editing and other applications. Read moreRead less
How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative e ....How a ubiquitous endosymbiont of insects protects against pathogens. The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative evolutionary and genetic approaches, the project proposes to elucidate the mechanism of pathogen blocking and ascertain its broader consequences for the host. This knowledge may be critical for maintaining the effectiveness of the biocontrol approach in the field by informing the development of resistance management strategies.Read moreRead less
The evolution of host-parasite interactions during a biological invasion. This project aims to elucidate how host organisms and their parasites adapt to each other, exploiting the fact that a biological invasion imposes novel evolutionary challenges. This project expects to generate new knowledge about how the interaction between host and parasite species is affected when the system is exposed to powerful new selective forces. Expected outcomes of this project include development of theory, trai ....The evolution of host-parasite interactions during a biological invasion. This project aims to elucidate how host organisms and their parasites adapt to each other, exploiting the fact that a biological invasion imposes novel evolutionary challenges. This project expects to generate new knowledge about how the interaction between host and parasite species is affected when the system is exposed to powerful new selective forces. Expected outcomes of this project include development of theory, training of students in an emerging field, and a nuanced understanding of this important topic. This should provide significant benefits, such as an enhanced ability for wildlife managers to predict the impact of parasites on species of wildlife that are extending their geographic ranges.Read moreRead less
Genomic diversity, tolerance and ecology of wildlife disease. This project aims to understand the regulation of viral disease by vertebrate hosts. Viruses are rapidly evolving threats to humans, agriculture and wildlife and understanding of these threats can be transformed by combining the latest genomic, ecological and immune-pathological approaches. This project expects to reveal how hosts manage the bad effects of viruses in natural populations and fill gaps in fundamental knowledge of virus- ....Genomic diversity, tolerance and ecology of wildlife disease. This project aims to understand the regulation of viral disease by vertebrate hosts. Viruses are rapidly evolving threats to humans, agriculture and wildlife and understanding of these threats can be transformed by combining the latest genomic, ecological and immune-pathological approaches. This project expects to reveal how hosts manage the bad effects of viruses in natural populations and fill gaps in fundamental knowledge of virus-host evolution. Anticipated benefits include improved management, risk assessment and decision-making for animal disease and biosecurity in Australia and globally.Read moreRead less