Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling w ....An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling with a novel experimental protocol to allow the study of kinetics of parasite replication in vivo. Expected outcomes will provide significant benefits, such as new avenues for vaccination and immune intervention.Read moreRead less
New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens hav ....New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens have been identified, the environmental catalysts of oyster disease remain a mystery. The expected outcome of this project is an innovative coupling of tools that provides new capacity to forecast disease events, delivering the Australian oyster industry a powerful platform to predict, manage and prevent costly disease outbreaks. By identifying environmental thresholds and oyster disease danger periods, an expected outcome of this project is the development of new oyster farming strategies aimed at avoiding multi-million dollar losses associated with disease outbreaks.Read moreRead less