Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Improving vaccine performance through understanding host-pathogen interaction in yersiniosis. This project will significantly contribute to the economic and environmental sustainability of the Australian salmon industry. It will reduce salmon production costs, ensure sufficient supply of fish from hatchery to grow-out and reduce the use of antibiotics. Reduced use of antibiotics will benefit both the environment and human health. As the salmon industry is based in regional and rural areas, th ....Improving vaccine performance through understanding host-pathogen interaction in yersiniosis. This project will significantly contribute to the economic and environmental sustainability of the Australian salmon industry. It will reduce salmon production costs, ensure sufficient supply of fish from hatchery to grow-out and reduce the use of antibiotics. Reduced use of antibiotics will benefit both the environment and human health. As the salmon industry is based in regional and rural areas, this project will support rural and regional communities. This project will further strengthen Australian leadership in aquaculture research through use of molecular methods to address industry issues and will therefore increase the competitiveness of Australian science.Read moreRead less
Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms f ....Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms for condensed storage, establishing flow sensor and blood flow relationships and assessment of sensor stability and calibration demands. The device will facilitate research in pulmonary hypertension and may lead to clinical devices for monitoring effectiveness of treatment.Read moreRead less
Phytochemistry Of Thrips Resistance In Potato And Its Influence On Acquisition And Transmission Of Tomato Spotted Wilt Virus. TSWV causes multi-million dollar losses to the Australian potato industry, which is the countries largest and most valuable vegetable commodity and an important source of income and employment for rural communities. Development of TSWV epidemics relies on the activity of vector thrips acquiring virus from infected plants and transmitting it to healthy potatoes. Deployment ....Phytochemistry Of Thrips Resistance In Potato And Its Influence On Acquisition And Transmission Of Tomato Spotted Wilt Virus. TSWV causes multi-million dollar losses to the Australian potato industry, which is the countries largest and most valuable vegetable commodity and an important source of income and employment for rural communities. Development of TSWV epidemics relies on the activity of vector thrips acquiring virus from infected plants and transmitting it to healthy potatoes. Deployment of thrips resistant potato would greatly assist disease control. This project will determine the efficacy of thrips resistance in reducing TSWV epidemics and identify the chemical basis of resistance, which could be used as a screening tool for potato breeding, and could form the basis of a synthetic chemical tool for thrips prevention in potato and other crops.Read moreRead less
Compost extract: a new paradigm for disease management in sustainable horticulture. There is significant legislative and consumer pressure worldwide to reduce the amount of pesticide applied to food crops. Compost extract is a watery extract of mature compost that when applied to a crop canopy allows simultaneous suppression of a broad range of plant diseases while maintaining biodiversity in an agricultural ecosystem. This technology represents a paradigm shift from the monoculture approach o ....Compost extract: a new paradigm for disease management in sustainable horticulture. There is significant legislative and consumer pressure worldwide to reduce the amount of pesticide applied to food crops. Compost extract is a watery extract of mature compost that when applied to a crop canopy allows simultaneous suppression of a broad range of plant diseases while maintaining biodiversity in an agricultural ecosystem. This technology represents a paradigm shift from the monoculture approach of single-target fungicides or biological control agents. Scientific evaluation has been hampered by a lack of standard production techniques. Our aim is to identify and characterise compost extract technology that produces known and consistently high levels of effectiveness and safety.Read moreRead less
Linking plant genetics and chemistry to maximise tree production in the softwood industry. This project aims to test a ‘gene to plantation’ approach for the management of pests in softwood forestry. The project aims to focus on the stripping of bark from Pinus radiata trees by mammals: a major threat to tree productivity in many regions of Australia and an economic burden for forestry companies. The project aims to use a wide complement of P. radiata germplasm to link genetics, bark defensive ch ....Linking plant genetics and chemistry to maximise tree production in the softwood industry. This project aims to test a ‘gene to plantation’ approach for the management of pests in softwood forestry. The project aims to focus on the stripping of bark from Pinus radiata trees by mammals: a major threat to tree productivity in many regions of Australia and an economic burden for forestry companies. The project aims to use a wide complement of P. radiata germplasm to link genetics, bark defensive chemistry and susceptibility to damage. It aims to identify genotypes with increased resistance, unravel defensive tree traits, screen for genetic markers and identify specific gene regions correlated with trait variation, and examine cross-correlations with other major tree productivity traits.Read moreRead less
Risk, impact on productivity and control of Mycosphaerella infections in plantations in plantations of E. nitens and E. globulus. Mycosphaerella, a defoliating fungal pathogen of eucalypts, has the potential to change markedly the economics of plantation development. This research will explore the fundamental physiological and pathological processes associated with the disease, link these findings into established process-based models of forest plantation growth for predictive purposes and util ....Risk, impact on productivity and control of Mycosphaerella infections in plantations in plantations of E. nitens and E. globulus. Mycosphaerella, a defoliating fungal pathogen of eucalypts, has the potential to change markedly the economics of plantation development. This research will explore the fundamental physiological and pathological processes associated with the disease, link these findings into established process-based models of forest plantation growth for predictive purposes and utilise hyperspectral remote sensing techniques to scale impact from the tree to plantation level. In doing this research not only are questions of key importance to an important and growing industry sector addressed, but an innovative approach to disease impact assessment established and a skills base and methodology widely applicable to other tree and agricultural disease problems established.Read moreRead less
Protecting Australia's pine plantations from exotic pests and climate change. This project will protect pine plantations (representing 57% of Australia's $3.3 billion pa forestry industry) from the dual threat of exotic pests and climate change. Sirex wood wasp has been well controlled until the recent, unprecedented, increase of ips bark beetles. The ips beetle is now disrupting biological control of sirex by its feeding activity so work is required to understand and combat this effect. The wor ....Protecting Australia's pine plantations from exotic pests and climate change. This project will protect pine plantations (representing 57% of Australia's $3.3 billion pa forestry industry) from the dual threat of exotic pests and climate change. Sirex wood wasp has been well controlled until the recent, unprecedented, increase of ips bark beetles. The ips beetle is now disrupting biological control of sirex by its feeding activity so work is required to understand and combat this effect. The work is made more urgent by looming climate change because storm-damage, drought and heat stressed trees are especially vulnerable to sirex attack. It is estimated that this novel pest management approach could save the industry at least $188 million pa based on a conservative estimate of reducing losses by 10%.Read moreRead less
Determining generic indicators of stress in eucalypt leaves for application to the remote sensing of canopy condition and productivity modelling. Biotic and abiotic stresses induce generic alterations of leaf chemistry (e.g. chlorophyll, anthocyanins). We will explore the behaviour of eucalypt leaf reflectance to changes in leaf cellular chemistry and structure arising from exposure to a range of stressful factors. We will relate leaf reflectance to physiological processes using a research radia ....Determining generic indicators of stress in eucalypt leaves for application to the remote sensing of canopy condition and productivity modelling. Biotic and abiotic stresses induce generic alterations of leaf chemistry (e.g. chlorophyll, anthocyanins). We will explore the behaviour of eucalypt leaf reflectance to changes in leaf cellular chemistry and structure arising from exposure to a range of stressful factors. We will relate leaf reflectance to physiological processes using a research radiation interception model. We will report on a) the potential integration of data related to stress, into process-based models for eucalypt plantation growth and b) the exploitation of generic reflectance indicators of stress in the remote acquisition of high resolution multispectral imagery with potential to spatially quantify plantation eucalypt health.Read moreRead less
Development of a risk management system for systemic downy mildew of poppies. Development of a risk management system for systemic downy mildew of poppies. This project aims to identify the critical inoculum sources of systemic downy mildew—a new disease threat to the Australian poppy industry, which produces over half the world’s medicinal opiates. It will assess these sources’ relative importance and interaction with agronomic site factors in epidemics; and also intends to understand the syste ....Development of a risk management system for systemic downy mildew of poppies. Development of a risk management system for systemic downy mildew of poppies. This project aims to identify the critical inoculum sources of systemic downy mildew—a new disease threat to the Australian poppy industry, which produces over half the world’s medicinal opiates. It will assess these sources’ relative importance and interaction with agronomic site factors in epidemics; and also intends to understand the systemic progression in planta, an area poorly understood in all downy mildew pathosystems. The project expects the data will form the basis of a disease risk index tool to educate growers and guide disease management strategies essential to this industry’s long term viability.Read moreRead less