In-vivo detection of airway injury and disease using phase contrast X-ray velocimetry. Currently diagnosis of lung disease, a major cause of death in humans, is based on clinical symptoms that do not usually manifest until the disease is well advanced. This project will develop a novel imaging technique, X-ray velocimetry, to detect changes in tissue before symptoms arise, potentially leading to strategies for managing lung diseases.
Minimally invasive monitoring of sleep for disease management. Sleep, diet and exercise are the three pillars of wellbeing with poor sleep associated with medical issues such as obesity and congestive heart failure. This project will advance sleep analysis by researching new ways of monitoring that are highly accurate and convenient, enabling physicians to improve the monitoring of significant health issues.
Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many know ....Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many known resistance mutations, and may have specific practicality against N1 neuraminidase in H1N1 and H5N1 viruses responsible for all pandemics of the 20th and 21st centuries. The research will enable the potential of these inhibitors to be fully assessed at the molecular level for the first time.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100035
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Hyperpolarised gas functional lung and molecular imaging. This project will produce a polariser to generate magnetised gas for research with magnetic resonance imaging (MRI). This allows imaging of normal and abnormal lung ventilation and circulation in animal and humans. The use of these hyperpolarised gases can also be used to tag specific molecules and increase understanding of lung metabolism.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Individually addressable, active, multipoint electrodes for bio-potential recording and electrical impedance imaging. We will develop non-invasive devices based on biosignal and impedance monitoring. They will be highly portable and based on comfortable electrode patches that can be applied quickly in emergencies. The technology may be used to save lives and reduce disabilities by monitoring strokes and heart attacks and stimulate Australia's biomedical industry.
Integrated multi-level interpretation and its applications for intelligent multimodality biomedical image navigation, retrieval and tracking. The 64- and 128-slice positron emission tomography – computed tomography (PET-CT) devices at the Royal Prince Alfred Hospital were the first in the country. These scanners, with the medical cyclotron and radiochemistry facilities, represent an investment of over A$13 million. This project will address pressing issues in optimising the utilisation of the in ....Integrated multi-level interpretation and its applications for intelligent multimodality biomedical image navigation, retrieval and tracking. The 64- and 128-slice positron emission tomography – computed tomography (PET-CT) devices at the Royal Prince Alfred Hospital were the first in the country. These scanners, with the medical cyclotron and radiochemistry facilities, represent an investment of over A$13 million. This project will address pressing issues in optimising the utilisation of the information and systems to provide better service to patients and referring clinicians. This research will add considerable value to Australia's medical imaging infrastructure and healthcare delivery; and advance scientific research in better understanding of system biology, physiology and pathology. The research outcomes will strengthen Australia’s leading position in biomedical information technology research and Australian medical imaging expertise.Read moreRead less
Biomedical Visual Image Analytics for Multi-disciplinary Retrieval. The project aims to develop a framework to provide users with the interactive access to information that is necessary for the best collaborative decision-making. Visual analytics theory is becoming increasing valuable for managing ‘big data’ because it can provide interactive and intuitive understanding of the rich information embedded within complex data and decision support systems. There are, however, fundamental challenges t ....Biomedical Visual Image Analytics for Multi-disciplinary Retrieval. The project aims to develop a framework to provide users with the interactive access to information that is necessary for the best collaborative decision-making. Visual analytics theory is becoming increasing valuable for managing ‘big data’ because it can provide interactive and intuitive understanding of the rich information embedded within complex data and decision support systems. There are, however, fundamental challenges that currently prevent visual analytics from being routinely applied to multi-disciplinary collaboration, which is now ‘the norm’ to solve large complicated problems where there is significant social impact. This project aims to address these challenges and improve visual analytics theory by developing a biomedical visual image analytics framework that enables interactive information retrieval of multidisciplinary databases.Read moreRead less
Multiscale integration of imaging and omics data. This project aims to integrate multiscale imaging and molecular data to characterise disease in patients. Modern healthcare needs to embrace ‘big (health) data’s potential to address an ageing population’s increasing healthcare demands and the inefficiencies and waste in patient treatment. This project expects to pioneer basic science research in methodologies to integrate, correlate and then derive knowledge from multi-scale data, to characteris ....Multiscale integration of imaging and omics data. This project aims to integrate multiscale imaging and molecular data to characterise disease in patients. Modern healthcare needs to embrace ‘big (health) data’s potential to address an ageing population’s increasing healthcare demands and the inefficiencies and waste in patient treatment. This project expects to pioneer basic science research in methodologies to integrate, correlate and then derive knowledge from multi-scale data, to characterise the mechanisms of disease in individual patients, in space and time. Its integrated model is expected to form the basis of a framework for individualised patient disease analysis.Read moreRead less
Mechanisms of initiation and remodelling of intracranial aneurysms: a synthesis of hemodynamics and molecular biomarkers. Rupture of brain aneurysms can lead to severe disability and death. This project proposes novel ways of assessing risk of rupture using sophisticated mathematical models of blood flow in aneurysms and biochemical substances released in the blood. This will enhance basic understanding of aneurysm formation and improve treatment and management.