Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
Buffering the ecosystem impact of invasive cane toads. This project aims to address the devastating ecological problems caused by invasive species, by developing a novel approach that does not rely upon eradicating the invader through training vulnerable native predators not to eat toxic cane toads. Expected outcomes of this project include building a broad coalition of conservation-focused groups, from private land-owners and local businesses through to Indigenous groups and government and non- ....Buffering the ecosystem impact of invasive cane toads. This project aims to address the devastating ecological problems caused by invasive species, by developing a novel approach that does not rely upon eradicating the invader through training vulnerable native predators not to eat toxic cane toads. Expected outcomes of this project include building a broad coalition of conservation-focused groups, from private land-owners and local businesses through to Indigenous groups and government and non-government agencies across the entire Kimberley region. It will also result in the evaluation of methods for deployment of taste-aversion at a landscape scale. This should provide significant benefits by conserving vulnerable fauna and building a powerful network within a region of high biodiversity in tropical Australia.Read moreRead less
Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledg ....Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users. Read moreRead less
Eco-friendly pesticides for crop protection. The aims of the project are to develop robust methods for measuring bioactive pesticidal molecules in butterfly pea cultivars, characterise their modes of action, determine the exposure and persistence of these molecules in field runoff and waterways and, in the longer term, develop butterfly pea cultivars with optimised bioactivity and safety. The major outcome of the project is the generation of new knowledge that will contribute to the development ....Eco-friendly pesticides for crop protection. The aims of the project are to develop robust methods for measuring bioactive pesticidal molecules in butterfly pea cultivars, characterise their modes of action, determine the exposure and persistence of these molecules in field runoff and waterways and, in the longer term, develop butterfly pea cultivars with optimised bioactivity and safety. The major outcome of the project is the generation of new knowledge that will contribute to the development of novel antifungal and insecticidal agents. This outcome is significant as there is a huge need for new pesticidal agents that exhibit wide safety margins, reduce problems associated with resistance to existing treatments, and that are safe for the environment.Read moreRead less
Using cane toads to eradicate cane toads. This project aims to develop effective ways to reduce the devastating ecological impact of cane toads, by exploiting the cannibalistic behaviour of tadpoles. This project expects to generate new knowledge in the area of invasion biology and amphibian development utilising recent discoveries about cannibalism. Expected outcomes of this project include a powerful new method to reduce or eliminate recruitment of juvenile toads from natural waterbodies. Bene ....Using cane toads to eradicate cane toads. This project aims to develop effective ways to reduce the devastating ecological impact of cane toads, by exploiting the cannibalistic behaviour of tadpoles. This project expects to generate new knowledge in the area of invasion biology and amphibian development utilising recent discoveries about cannibalism. Expected outcomes of this project include a powerful new method to reduce or eliminate recruitment of juvenile toads from natural waterbodies. Benefits of this project include conservation of native wildlife that are threatened by the cane toad invasion across much of tropical and subtropical Australia.Read moreRead less
The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum ....The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler. This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum performance, delivering typically less than 20% of the loaded dose to the target site, the lungs. The new fundamental knowledge resulting from this research will enable the engineering of a high-efficiency groundbreaking DPI, with the potential to be fully adaptive user-specific benefiting millions of Australians. Read moreRead less
Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will ena ....Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will enable science-based guidelines, advancing disease control, local eradication, and regulatory approval for wombats. Our research framework is adaptable to other mange-impacted species, and advance methods and theory for control of treatable disease in wildlife.Read moreRead less
Understanding population growth time lags in invasive species. This project will use data collected from wild animals, landholder surveys, and computer simulation models to understand why invasive chital deer (Axis axis) are suddenly increasing in number after many years of slow population growth. By combining multiple empirical datasets and developing new modelling techniques, we will generate a new method for understanding population trends in introduced species. The results of this study will ....Understanding population growth time lags in invasive species. This project will use data collected from wild animals, landholder surveys, and computer simulation models to understand why invasive chital deer (Axis axis) are suddenly increasing in number after many years of slow population growth. By combining multiple empirical datasets and developing new modelling techniques, we will generate a new method for understanding population trends in introduced species. The results of this study will allow Queensland Department of Agriculture and Fisheries and others to better predict invasive species growth rates, which will allow for better, and more cost effective control methods. Read moreRead less
Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulation ....Enabling precise droplet control in hydrofluorocarbon free sprays. This project aims to investigate the use of blended propellants to replace hydrofluorocarbons in technical aerosols. This project expects to generate new knowledge in the area of multiphase fluid mechanics and aerosol science through a combination of modeling, optical and synchrotron X-ray measurement techniques. Expected outcomes of this project include a capacity to develop environmentally friendly technical aerosol formulations which can match and potentially outperform currently available hydrofluorocarbon based products. This should provide significant benefits to the pharmaceutical industry through the generation of new knowledge regarding the fundamental physics of multicomponent sprays.Read moreRead less
Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si a ....Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si alleviates stress in wheat, from gene to farm scale, providing cost-benefit analysis and a best–practice toolbox for implementation by farmers. Outcomes are anticipated to provide a cheaper and more environmentally sustainable solution to issues of water scarcity and yield losses to pests in Australia’s leading crop.Read moreRead less