Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantif ....Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantify the interactive impact of temperature and nutrition on immune function, disease resistance and host-plant quality of plague locusts; and to explore the combined effects of temperature, habitat and Green Guard, in combination with candidate microbes or pathogens, on the behaviour and collective movement of locusts. It is anticipated that this will have implications for management and control strategies.Read moreRead less
Development of environmentally-friendly bioinsecticides for control of Australian crop pests. Insect pests cause over $3 billion of damage each year to Australian crops. Current insecticides are becoming less effective, and they often have adverse environmental impacts. This project aims to develop a new generation of environmentally-friendly insecticides that can be used to control insect pests on farms and around the home and garden.
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted u ....Australian plague locust population genetics and migratory behaviour. The project will allow improved monitoring and forecasting of locusts in Australia and thereby help prevent locust outbreaks. Benefits will arise directly through greater effectiveness in reducing locust damage to crops, and indirectly to Australian rural industry generally through the economic benefits of reduced losses and locust control costs. Environmental and social benefits will also arise from reduced, better targeted use of chemical insecticides. This in turn can produce secondary economic benefits, e.g. through enhanced growth and profitability of the organic beef industry within the main locust-outbreak area. Read moreRead less
Extinction of turtles in the River Murray: Consequences and Solutions. Turtles are a major ecological component of the Murray-Darling, Australia’s major river system. They are declining alarmingly with potential dire consequences for water quality, biodiversity, and river health. This project unites a world-class research team with diverse industry partners, indigenous groups, and non-government organisations from three states to address a problem of national significance. This project aims to i ....Extinction of turtles in the River Murray: Consequences and Solutions. Turtles are a major ecological component of the Murray-Darling, Australia’s major river system. They are declining alarmingly with potential dire consequences for water quality, biodiversity, and river health. This project unites a world-class research team with diverse industry partners, indigenous groups, and non-government organisations from three states to address a problem of national significance. This project aims to identify and quantify causes of declines in turtles along the whole system, with the aim of developing practical management options to overcome it. This will be the first river-wide study of turtles, achieved by combining cutting-edge genetic and ecological techniques with a citizen science program.Read moreRead less
Impacts of locust control pesticides on arid-zone fauna. Impacts of locust control pesticides on arid-zone fauna. This project aims to understand how different animals encounter pesticide in the landscape through quantifying residue deposition in arid grasslands and investigating how pesticides used to control locust plagues affect fauna. This project will investigate fenitrothion and fipronil, the main pesticides used in Australia for locust control. It will develop a deposition model for aeria ....Impacts of locust control pesticides on arid-zone fauna. Impacts of locust control pesticides on arid-zone fauna. This project aims to understand how different animals encounter pesticide in the landscape through quantifying residue deposition in arid grasslands and investigating how pesticides used to control locust plagues affect fauna. This project will investigate fenitrothion and fipronil, the main pesticides used in Australia for locust control. It will develop a deposition model for aerial pesticide spraying, determine the short-term effect of sprayed pesticides on the behaviour and condition of free-ranging target fauna that use the environment differently, and quantify the relative importance of dietary and non-dietary exposure routes to gauge the importance of animal behaviour on pesticide exposure. Anticipated outcomes are improved baseline assessments for locusticides.Read moreRead less
Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si a ....Silicon: a novel solution to reduce water use and pest damage in wheat. The project aims to improve Australian wheat production by increasing drought resilience and reducing reliance on pesticides. This is achieved by incorporating amorphous silicon (Si), an abundant national resource. Si uptake by wheat has been proven to alleviate stress from drought and pests, but mechanisms and agronomic feasibility remain to be fully assessed. The project will deliver a mechanistic understanding of how Si alleviates stress in wheat, from gene to farm scale, providing cost-benefit analysis and a best–practice toolbox for implementation by farmers. Outcomes are anticipated to provide a cheaper and more environmentally sustainable solution to issues of water scarcity and yield losses to pests in Australia’s leading crop.Read moreRead less
An Open Source Approach to Understanding an Important Parasite Ion Pump. This project plans to synthesise new compounds that bind the protein ATP4, an essential ion pump in the malaria parasite. It plans to generate a three-dimensional map to understand how these compounds stop ATP4 from working. Several promising new medicines for malaria target ATP4, yet we do not understand properly how they do so. The project’s intended aims will be achieved using new methods in synthetic chemistry and membr ....An Open Source Approach to Understanding an Important Parasite Ion Pump. This project plans to synthesise new compounds that bind the protein ATP4, an essential ion pump in the malaria parasite. It plans to generate a three-dimensional map to understand how these compounds stop ATP4 from working. Several promising new medicines for malaria target ATP4, yet we do not understand properly how they do so. The project’s intended aims will be achieved using new methods in synthetic chemistry and membrane biology, and by leveraging global scientific inputs through online research methods allowing anyone to participate.Read moreRead less