Discovery Early Career Researcher Award - Grant ID: DE230100730
Funder
Australian Research Council
Funding Amount
$448,000.00
Summary
Strategies to minimise the societal impacts of zoonotic pandemics. The continuing pandemic has had unprecedented effects across society. Population mobility restrictions have been effective in slowing transmission, but are only effective while in place and have dramatic adverse effects. Despite Australia’s relative success, we have lacked a clear national strategy to guide the optimal deployment of such restrictions. During this fellowship, I will use robust software development practices to dev ....Strategies to minimise the societal impacts of zoonotic pandemics. The continuing pandemic has had unprecedented effects across society. Population mobility restrictions have been effective in slowing transmission, but are only effective while in place and have dramatic adverse effects. Despite Australia’s relative success, we have lacked a clear national strategy to guide the optimal deployment of such restrictions. During this fellowship, I will use robust software development practices to develop a unified software platform that integrates semi-mechanistic, particle filter and agent-based methodologies. I will then use this platform to quantify the effects of mobility restrictions and define the optimal strategic response that should be selected based on the characteristics of a newly emerged pathogen.Read moreRead less
Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the ....Networks: New links between spectrum, dynamics, rewirings and applications. Modern network science has transformed the study of complex systems and led to innovations in many disciplines. This project intends to develop breakthrough theories for control of complex networked system behaviour via interventions of the link-rewiring type. New approaches will be developed for non-random, assortative and/or structured networks, which are poorly understood and difficult to deal with, despite being the real-world norm and despite their impact. The results will give new insights into epidemic outbreaks and their impact on vulnerable groups (e.g., elderly and indigenous), and provides methods to enforce resilience of infrastructure networks such as power grids, thereby providing significant economic and societal benefits. Read moreRead less
Epidemics in large populations: long-term and near-critical behaviour. The project aims to prove qualitative and quantitative results concerning aspects of the long-term behaviour of near-critical epidemics, including the probability and duration of a large outbreak, and the total number of people infected. This project is a theoretical study of stochastic models of epidemics in large populations. The project will focus on emerging epidemics, where the average number of contacts, infection and r ....Epidemics in large populations: long-term and near-critical behaviour. The project aims to prove qualitative and quantitative results concerning aspects of the long-term behaviour of near-critical epidemics, including the probability and duration of a large outbreak, and the total number of people infected. This project is a theoretical study of stochastic models of epidemics in large populations. The project will focus on emerging epidemics, where the average number of contacts, infection and recovery rates are such that the basic reproduction number of the disease is near the critical value 1. The project will plan to both analyse particular epidemic models and develop new methodologies applicable in broader contexts. The mathematical predictions will be tested through simulations and comparison to real-world data. The significant outcome of the project should be the advancement in mathematical understanding of infectious disease spread, eventually leading to improved epidemic surveillance and control, and resulting in more effective protection of public health, improved quality of life, and obvious economic benefits.Read moreRead less
Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in res ....Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in response to ventilation and dynamic wastewater and atmospheric conditions, enabling model-based sewer ventilation design and operation. The project also aims to deliver novel, field-demonstrated ventilation strategies. The project findings will be incorporated in the Australian ventilation design and operation guidelines.Read moreRead less
Experiment-numerical-virtual Generative Design for Nondeterministic Impacts. This project will establish an advanced nondeterministic design methodology to uncover the optimised material properties and 3D printed metastructural capacity in real-time against impact loading. It will develop a rigorous framework that integrates numerical simulation, experiment, and machine learning-based virtual modelling to tackle practical challenges in design and manufacture of impact-proof materials and structu ....Experiment-numerical-virtual Generative Design for Nondeterministic Impacts. This project will establish an advanced nondeterministic design methodology to uncover the optimised material properties and 3D printed metastructural capacity in real-time against impact loading. It will develop a rigorous framework that integrates numerical simulation, experiment, and machine learning-based virtual modelling to tackle practical challenges in design and manufacture of impact-proof materials and structures with intrinsic uncertainties. The generative design-calibration system unifying experimental-numerical-virtual processes will largely reduce the need for repetitive large-scale experimental tests. This project benefits civil, aerospace, automotive, and defence with competitive advantage through technological innovation.Read moreRead less
Hitting bacteria with a Bam: Lectin-Like Antimicrobials as New Antibiotics. Antibiotic resistance in disease-causing bacteria is a rapidly growing problem, making the development of new antibiotics of critical importance. This project aims to develop naturally produced lectin-like protein antibiotics as novel antimicrobial agents. To achieve this, the project will produce an extensive library of these antibiotics and test them for potency and specificity. Using cutting-edge techniques, it will d ....Hitting bacteria with a Bam: Lectin-Like Antimicrobials as New Antibiotics. Antibiotic resistance in disease-causing bacteria is a rapidly growing problem, making the development of new antibiotics of critical importance. This project aims to develop naturally produced lectin-like protein antibiotics as novel antimicrobial agents. To achieve this, the project will produce an extensive library of these antibiotics and test them for potency and specificity. Using cutting-edge techniques, it will determine how these antibiotics kill cells on a molecular and cellular level. It is anticipated this research will create the tools and knowledge required to exploit lectin-like protein antibiotics to fight bacterial infection, which will lead to their use in the prevention of crop and livestock losses due to disease.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101467
Funder
Australian Research Council
Funding Amount
$419,778.00
Summary
The geometric structure of spatial noise. Spatial noise is ubiquitous in nature and science: as interference in medical imaging, in oceanography, in the modelling of telecommunication networks etc. Despite this diversity of sources, spatial noise can be studied in a unified way by considering mathematical models that capture its essential features. This project aims to study spatial noise by analysing its geometric structure, for instance by considering the number of contour lines of the noise, ....The geometric structure of spatial noise. Spatial noise is ubiquitous in nature and science: as interference in medical imaging, in oceanography, in the modelling of telecommunication networks etc. Despite this diversity of sources, spatial noise can be studied in a unified way by considering mathematical models that capture its essential features. This project aims to study spatial noise by analysing its geometric structure, for instance by considering the number of contour lines of the noise, and the way these lines connect different regions of space. The project further aims to apply this analysis to construct statistical tests that can distinguish different classes of spatial noise, with potential applications across all of the disciplines mentioned above.Read moreRead less
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project ....Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project outcomes are intended to lead to significant advances in membrane protein structure determination and will have a substantial impact on future research in the pharmaceutical industry.Read moreRead less