Biofocussed Prostate Cancer RadioTherapy (BiRT): A Personalised Approach To Delivering The Right Dose To The Right Place
Funder
National Health and Medical Research Council
Funding Amount
$753,565.00
Summary
We propose a new approach to treating prostate cancer with radiotherapy to move from the standard whole prostate treatment to a personalised treatment that varies radiation intensity throughout the prostate. We will mathematically combine features that influence radiotherapy effect from advanced imaging, clinical and biopsy information. This model will map out the radiotherapy dose required at each part of the prostate, to maximise killing of the cancer whilst minimising harm to normal tissue
Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a yea ....Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a year in Australia alone. This project is a major joint effort by the Australian water industry and world-leading scientists to generate advanced knowledge and develop effective technologies for optimal odour and corrosion management in sewers, delivering large social, environmental and economic benefits.Read moreRead less
Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in res ....Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in response to ventilation and dynamic wastewater and atmospheric conditions, enabling model-based sewer ventilation design and operation. The project also aims to deliver novel, field-demonstrated ventilation strategies. The project findings will be incorporated in the Australian ventilation design and operation guidelines.Read moreRead less
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.
Periodontal Disease And Chronic Kidney Disease Among Aboriginal Adults; An RCT
Funder
National Health and Medical Research Council
Funding Amount
$1,035,550.00
Summary
Chronic Kidney Disease is a growing public health concern in Australia, especially among Aboriginal populations. It is associated with progression to end stage kidney disease requiring dialysis, cardiovascular disease burden and high mortality. This study will use a randomised controlled trial design to determine if comprehensive periodontal therapy reduces progression of kidney disease among Aboriginal adults with chronic kidney disease residing in Central Australia.
Experiment-numerical-virtual Generative Design for Nondeterministic Impacts. This project will establish an advanced nondeterministic design methodology to uncover the optimised material properties and 3D printed metastructural capacity in real-time against impact loading. It will develop a rigorous framework that integrates numerical simulation, experiment, and machine learning-based virtual modelling to tackle practical challenges in design and manufacture of impact-proof materials and structu ....Experiment-numerical-virtual Generative Design for Nondeterministic Impacts. This project will establish an advanced nondeterministic design methodology to uncover the optimised material properties and 3D printed metastructural capacity in real-time against impact loading. It will develop a rigorous framework that integrates numerical simulation, experiment, and machine learning-based virtual modelling to tackle practical challenges in design and manufacture of impact-proof materials and structures with intrinsic uncertainties. The generative design-calibration system unifying experimental-numerical-virtual processes will largely reduce the need for repetitive large-scale experimental tests. This project benefits civil, aerospace, automotive, and defence with competitive advantage through technological innovation.Read moreRead less
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Defining Epigenetic Predictors Of Long-term Outcomes Of Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$409,408.00
Summary
On average, those born premature do worse health-wise than those born at term. However, some do worse than others. Our aim is to identify these people at birth to better help doctors and parents to closely monitor their health. For this, we will be “reading the diary of pregnancy” in the molecules added to chromosomes in blood during pregnancy in young adults with will characterised states of health. We will analyse DNA from blood that we will extract from stored heel prick spots.
Overseeing the internet: new paradigms of network measurement. Like the electricity network, the internet is a core infrastructure, and so must be reliable and efficient. A gap in bandwidth supply is like a blackout in terms of lost business and productivity. This project will provide the measurement breakthroughs to ensure that network behaviour can be accurately and comprehensively monitored.