Optimising Intervention Strategies To Reduce The Burden Of Group A Streptococcus In Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$856,896.00
Summary
Skin sores are highly prevalent in remote Australian Indigenous communities and can lead to invasive infections and rheumatic heart disease. We will develop mathematical models to understand the transmission of skin sores, allowing us to define the optimal extent (household, community, region), timing and triggers for interventions to interrupt transmission. This will guide public health policy in reducing the prevalence of skin sores and scabies, and their accompanying disease burden.
A New Approach to Air Traffic Management to Deliver Significantly Reduced Environmental Impact and System-wide Efficiencies. Aviation is often cited as a major contributor to harmful emissions in the upper atmosphere. The primary outcome of this project is the development of tools that will enable aviation industry stakeholders to optimise the deployment of 4-Dimensional User Preferred Trajectories across Australian airspace. It is expected that this will result in significant environmental bene ....A New Approach to Air Traffic Management to Deliver Significantly Reduced Environmental Impact and System-wide Efficiencies. Aviation is often cited as a major contributor to harmful emissions in the upper atmosphere. The primary outcome of this project is the development of tools that will enable aviation industry stakeholders to optimise the deployment of 4-Dimensional User Preferred Trajectories across Australian airspace. It is expected that this will result in significant environmental benefit, through reductions in fuel burn for each flight, and increases in system effectiveness. The project will enable better analysis of Australian aviation environmental effect, whilst at the same time allowing the aviation industry to continue to contribute to Australia's sustainable economic growth. Read moreRead less
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Reconstructing land tenure maps of Australia in 3D. Existing land tenure maps of above and below ground, such as apartment ownership, tunnels, and mining, are maintained using 2D drawings. However, the drawings are not structured and valuable for detailed and advanced visualisation, analytics, and simulation, which are essential for testing potential interventions and policy development. This project aims to develop a data validation framework for transforming current drawings and reconstructing ....Reconstructing land tenure maps of Australia in 3D. Existing land tenure maps of above and below ground, such as apartment ownership, tunnels, and mining, are maintained using 2D drawings. However, the drawings are not structured and valuable for detailed and advanced visualisation, analytics, and simulation, which are essential for testing potential interventions and policy development. This project aims to develop a data validation framework for transforming current drawings and reconstructing them into 3D models. The outcomes include validation principles, formal mathematical terms, and computational algorithms. Benefits include a cost-effective onshore alternative to offshore 3D reconstruction practices, efficient land development and infrastructure planning, and fewer property disputes.Read moreRead less
Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a yea ....Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a year in Australia alone. This project is a major joint effort by the Australian water industry and world-leading scientists to generate advanced knowledge and develop effective technologies for optimal odour and corrosion management in sewers, delivering large social, environmental and economic benefits.Read moreRead less
Understanding the Biotransformation Processes in a Sewer System to Achieve Optimal Management. Sewer corrosion and odour emissions are incurring massive costs to the wastewater management authorities. These problems are primarily caused by the hydrogen sulfide produced by the in-sewer biotransformation processes. Through integrating controlled laboratory experiments, extensive field measurement/experiments and advanced computer modelling, the project aims to generate a fundamental understanding ....Understanding the Biotransformation Processes in a Sewer System to Achieve Optimal Management. Sewer corrosion and odour emissions are incurring massive costs to the wastewater management authorities. These problems are primarily caused by the hydrogen sulfide produced by the in-sewer biotransformation processes. Through integrating controlled laboratory experiments, extensive field measurement/experiments and advanced computer modelling, the project aims to generate a fundamental understanding of the in-sewer biotransformation processes, in particular those occurring in sewer biofilms and sediments, and to provide scientific and engineering support to the wastewater authorities to manage their sewers in a more cost-effective way. Emphasis is placed on the integrated sewer and wastewater treatment performance to achieve overall optimal wastewater management.Read moreRead less
Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in res ....Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in response to ventilation and dynamic wastewater and atmospheric conditions, enabling model-based sewer ventilation design and operation. The project also aims to deliver novel, field-demonstrated ventilation strategies. The project findings will be incorporated in the Australian ventilation design and operation guidelines.Read moreRead less
Micromechanical modelling of fault gouge dynamics: towards an improved fault constitutive relation. The human and economic costs of geological and other particulate media related problems in Australia are staggering. These include geological hazards (e.g. landslides and earthquakes; the Newcastle earthquake cost around $4 billion and 13 lives), to particulate processes prevalent in Australia's major export industries (e.g. coal export valued at $9.3 billion, iron ore at $3.8 billion, and wheat ....Micromechanical modelling of fault gouge dynamics: towards an improved fault constitutive relation. The human and economic costs of geological and other particulate media related problems in Australia are staggering. These include geological hazards (e.g. landslides and earthquakes; the Newcastle earthquake cost around $4 billion and 13 lives), to particulate processes prevalent in Australia's major export industries (e.g. coal export valued at $9.3 billion, iron ore at $3.8 billion, and wheat at $3.4 billion), to Australia's 810,000 km granular paved road network that costs around $5.5 million per day to maintain. The program will deliver new knowledge and advanced analytical and predictive modelling tools capable of fuelling breakthroughs in earthquake forecasting research and industrial innovations.
Read moreRead less
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.