Centre Of Research Excellence In Infectious Diseases Modelling To Inform Public Health Policy
Funder
National Health and Medical Research Council
Funding Amount
$2,600,064.00
Summary
Infectious diseases pose a global challenge, with substantial human and economic costs. Mathematical models provide valuable frameworks to assess likely benefits of interventions to control infection spread and burden. Leveraging existing NHMRC support, we will expand modeling capability to inform infectious disease control policy in Australia and our region. Focus areas include vaccine preventable disease, respiratory viruses and emerging pathogens, supported by innovative methods development.
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
The improvement of climate change investigations by developing and applying innovative evolutionary subset time series modelling using semi-parametric sparse-patterned approaches. With an estimated US$6.98 trillion loss indicated in the Stern review, severe climate change will make world climate conditions harsher and more likely include large natural climate disasters. The health of the Australian economy is critically dependent on decisions of environmental managers. However, most problems of ....The improvement of climate change investigations by developing and applying innovative evolutionary subset time series modelling using semi-parametric sparse-patterned approaches. With an estimated US$6.98 trillion loss indicated in the Stern review, severe climate change will make world climate conditions harsher and more likely include large natural climate disasters. The health of the Australian economy is critically dependent on decisions of environmental managers. However, most problems of complexity arising in climate change involve issues on which we do not possess a deep understanding. This project draws upon a set of inter-disciplinary concepts and models centred in neural networks that enable us to advance our understanding of complexity, leading to superior quantitative tools and models to allow for improved environmental decision-making.
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AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Protein Structure and Dynamics by Electron/Nuclear Paramagnetic Resonance. This interdisciplinary project aims to establish new magnetic resonance methods for the analysis of protein structure and motion at low concentrations and in physiological conditions that are otherwise difficult or impossible to study. It brings together four different research groups with expertise in advanced biochemistry, modern magnetic spectroscopy and high-performance computing. The project expects to develop tools ....Protein Structure and Dynamics by Electron/Nuclear Paramagnetic Resonance. This interdisciplinary project aims to establish new magnetic resonance methods for the analysis of protein structure and motion at low concentrations and in physiological conditions that are otherwise difficult or impossible to study. It brings together four different research groups with expertise in advanced biochemistry, modern magnetic spectroscopy and high-performance computing. The project expects to develop tools to study protein structure, protein-protein association and protein-ligand interactions of established drug-targets. Expected outcomes include new techniques that quickly inform how drugs work, providing significant benefits to many researchers studying biomolecules, and supporting Australia’s growing biotechnology sector. Read moreRead less
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Centre for Mathematical and Statistical Modelling of Complex Systems. This Centre, formed by a group of high-profile researchers, brings expertise from linked but hitherto disparate areas together. It will place Australia at the forefront of research into complex systems.
The mission of the Centre is to stimulate research in mathematical and statistical modelling of complex systems and to encourage cross-fertilisation of ideas and techniques. The specific objectives are
- to formulate and ana ....Centre for Mathematical and Statistical Modelling of Complex Systems. This Centre, formed by a group of high-profile researchers, brings expertise from linked but hitherto disparate areas together. It will place Australia at the forefront of research into complex systems.
The mission of the Centre is to stimulate research in mathematical and statistical modelling of complex systems and to encourage cross-fertilisation of ideas and techniques. The specific objectives are
- to formulate and analyse mathematical and statistical models for natural and artificial complex systems,
- to use these models to develop an understanding of the behaviour of these systems
- to incorporate this understanding into strategies for management and control.Read moreRead less
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.
Special Research Initiatives - Grant ID: SR0354575
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and me ....Earth and Ocean Informatics and Technology Network (EON-ITnet). Sustainable resource exploration and mining onshore, as well as marine planning, exploration, and defence depend on effective cross-disciplinary investigation, sharing of expertise and technologies for integration and computational analysis of multidimensional data spaces. EON-ITNET will cross-fertilise the use of artificial intelligence, advanced computing and smart information sharing for management, analysis, visualisation and metadata modelling between these traditionally separate research groups, with the outcome of improving research efficiency and lowering costs. EON-ITNET will form an alliance with the Caltech-based GeoFramework, which is advancing a novel object-oriented data analysis environment, binding community software for Earth visualisation and simulation to 4D data bases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less