Understanding The Developmental Basis Of Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
Kidney disease is a considerable burden on the health system and much of it derives from events that occur during organ development. In this grant I will investigate why human nephron number varies between people, how renal cysts form and what genes are mutated in patients with congenital kidney malformations.
Developmental Genetics And Stem Cell Biology Of Birth Defects And Cell Based Therapy
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Professor Tam is a mammalian embryologist studying the genetic and cellular mechanisms that form and shape the embryo and its organs during development. His work will help us to understand the causes of birth defects, how to prevent them and to correct the disorders by stem cell-based therapy.
Cerebral Palsy is most common childhood physical disability. While the brain injury is static, disability can be progressive and lifelong. This fellowship aims to develop and test novel interventions to optimise neuroplasticity by improving early detection and physical, cognitive, psychological and health outcomes in children with CP. Earlier accurate detection of CP will ensure effective treatments utilise critical periods of brain development and are translated into evidence based guidelines.
Early Life Exposures And Chronic Disease: Mechanisms And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The world is facing an epidemic of chronic disease and adverse environmental exposures in early life are partly responsible. One reason why we have not been able to do more to prevent this is the lack of appropriate methods for measuring environmental exposures during pregnancy and infancy. My research will develop and validate methods for measuring exposures early life and the health consequences of these exposures with the aim of developing preventative interventions
Lifecourse And Global Epidemiology Of Adolescent Health And Wellbeing
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
In the past 20 years, my group has become the world-leader in adolescent health research. We have published papers that have transformed thinking on adolescent health. In the next five years, we will undertake research into the effects of puberty on mental health, explore the effects of health prior to pregnancy on a healthy start to life for the next generation and undertake global research that will enable the roll-out of new multi-billion dollar investments in adolescent health.
Innovative Models Of Early Intervention For Conduct Disorders In Children
Funder
National Health and Medical Research Council
Funding Amount
$826,854.00
Summary
Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early i ....Most mental health problems begin in childhood, and Oppositional-defiant and conduct problems are the most reliable precursor of adult mental health problems. The lifetime costs on public services for these children are large. Australia has no strategy for managing this problem, and urgently needs to develop evidence-based approaches. This program of research will develop improved methods for identifying, assessing and treating child conduct disorders as part of our national strategy for early intervention for mental health.Read moreRead less
Translating Gene Discovery For Key Diseases Into Clinical Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
The goal of the fellowship is capitalize on successful gene mapping studies for endometriosis, inflammatory bowel disease (IBD), melanoma and other complex diseases and conduct functional studies, cross-disease analyses, and genetic studies of response to treatment. These studies will identify specific genes responsible for increased disease risk to understand the biology of these diseases, their relationship with other diseases, and help improve disease management and clinical outcomes.
I am a speech pathologist working with patients who have suffered a traumatic brain injury or stroke. Brain injury is the leading cause of disability in young Australians with devastating life consequences. A common problem is communication difficulties, which leads to relationship breakdowns, unemployability, and social isolation. This Fellowship will deliver innovative communication treatments to improve the social outcomes of people with brain injury, their families and the community.
Understanding Illness Trajectories And Developing Novel Therapies For Individuals With Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Understanding how the psychosis impacts on the patient and family will enable better planning of services and treatment, and facilitate the introduction of new rehabilitation/therapy options for patients at first episode of psychosis and beyond.
We will apply genome-wide approaches to identify the gene networks that regulate the self-renewal and the differentiation of muscle stem cells and their fusion to muscle fibres. These studies will deliver the first characterisation of the molecules and pathways implicated in these processes, which are essential steps of muscle growth.