A molecular timer for inflammation and cell death. This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not cu ....A molecular timer for inflammation and cell death. This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not currently understand how immune responses are temporally coordinated. This proposal aims to address this key knowledge gap by characterising a novel molecular timer that dictates the co-ordinated timing of immune responses and immune cell death. These studies may yield fundamental insight into mammalian anti-microbial mechanisms.Read moreRead less
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
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Australian Laureate Fellowships - Grant ID: FL160100089
Funder
Australian Research Council
Funding Amount
$2,600,796.00
Summary
In situ electron microscopy toward new materials and applications. In situ electron microscopy toward new materials and applications. This project aims to develop materials for structural and green energy applications, using spatially-resolved, dynamic in situ transmission electron microscopy to research fundamental mechanical, electrical, thermal, optical, optoelectronic and photovoltaic properties of diverse nanostructures. These techniques measure nanomaterial (one-dimensional nanotubes and n ....In situ electron microscopy toward new materials and applications. In situ electron microscopy toward new materials and applications. This project aims to develop materials for structural and green energy applications, using spatially-resolved, dynamic in situ transmission electron microscopy to research fundamental mechanical, electrical, thermal, optical, optoelectronic and photovoltaic properties of diverse nanostructures. These techniques measure nanomaterial (one-dimensional nanotubes and nanowires and two-dimensional graphene-like nanosheets) response to external stimuli, including mechanical, electrical, optical and thermal stimuli. Anticipated outcomes are new ultralight and superstrong structural composites and ‘green-energy’ nanomaterials, such as solar cells, touch panels, batteries, supercapacitors, field-effect transistors, light sensors and displays.Read moreRead less
Responsible Urban Innovation with Local Government Artificial Intelligence. Artificial intelligence (AI) is not only becoming an integral part of urban services, but also impacting and shaping the future of cities and societies. However, the current AI practice has shown that urban innovation without responsibility generates more problems than it solves. Especially, the absence of a deep understanding of the costs, benefits, risks and impacts of deploying government AI systems creates negative e ....Responsible Urban Innovation with Local Government Artificial Intelligence. Artificial intelligence (AI) is not only becoming an integral part of urban services, but also impacting and shaping the future of cities and societies. However, the current AI practice has shown that urban innovation without responsibility generates more problems than it solves. Especially, the absence of a deep understanding of the costs, benefits, risks and impacts of deploying government AI systems creates negative externalities and serious concerns in the society. This project will generate new knowledge on the most appropriate approaches for local governments to engage with AI to achieve responsible urban innovation. The project outcomes will include responsible AI adoption and implementation pathways for Australian local governments.Read moreRead less
Digital technologies and the private rental sector in Australia. This project aims to show how digital technologies are transforming the private rental sector in Australia. This project expects to generate new knowledge about the growing global reach of digital technologies aimed at private renters, landlords and property managers. The expected outcomes of this project include the production of social scientific knowledge about the potential of digital technologies to be both socially pernicious ....Digital technologies and the private rental sector in Australia. This project aims to show how digital technologies are transforming the private rental sector in Australia. This project expects to generate new knowledge about the growing global reach of digital technologies aimed at private renters, landlords and property managers. The expected outcomes of this project include the production of social scientific knowledge about the potential of digital technologies to be both socially pernicious and socially progressive. This project should provide significant benefits for Australian renters and our tenant advocacy partners who represent them, and to show how digital technologies can be used to create a better housing system.Read moreRead less
ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longi ....ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longitudinal family cohort study and children’s technology laboratories. The Centre will address tensions in a contested field to inform government and non-government policy, technology innovation, and develop programs and guidelines for children, families, educators and technology developers. Read moreRead less
Decoding the spatiotemporal control of DNA replication and repair. DNA replication is the fundamental mechanism of genetic inheritance and essential for all cellular life. This project aims to inform our understanding of how human cells coordinate the DNA replication machinery in time and space to accurately copy the human genome. By applying multiple innovative approaches and employing an interdisciplinary research team, this project is anticipated to generate new knowledge that explains how th ....Decoding the spatiotemporal control of DNA replication and repair. DNA replication is the fundamental mechanism of genetic inheritance and essential for all cellular life. This project aims to inform our understanding of how human cells coordinate the DNA replication machinery in time and space to accurately copy the human genome. By applying multiple innovative approaches and employing an interdisciplinary research team, this project is anticipated to generate new knowledge that explains how the human genome is replicated. This knowledge is expected to generate research publications of high quality and provide economic benefits, such as unlocking new potentially patentable DNA technologies. Read moreRead less
Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100223
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Advanced X-ray diffraction facility for high energy and extreme conditions. X-ray powder diffraction is a powerful technique for determining the structure of matter at the atomic scale. This project will establish a new Australian capability for X-ray powder diffraction under extreme conditions that emulate real harsh service environments for advanced functional materials.