Characterisation Of Eurl, A Novel Gene Implicated In The Etiology Of Abnormal Brain Development And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$597,541.00
Summary
Intellectual disability affects around one per cent of Australians, and can arise from genetic abnormalities during fetal life, such as through abnormal regulation of gene expression. We have identified a novel gene, known as eurl, which controls brain assembly as well as the ability of neurons to form functional connections within the brain. We will investigate how this novel gene controls brain development, and characterise eurl as a potential therapeutic target for learning and memory.
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Roads to the Future: Infrastructure and the New Development in Africa. This project aims to conduct a comparative analysis of new road schemes in East Africa and the Western Indian Ocean (a region which sits at the intersection of several major global transport and development corridors), in order to understand their economic, socio-political, cultural and public health effects. As global road-building accelerates at an unprecedented rate, especially in the developing world, there is an urgent n ....Roads to the Future: Infrastructure and the New Development in Africa. This project aims to conduct a comparative analysis of new road schemes in East Africa and the Western Indian Ocean (a region which sits at the intersection of several major global transport and development corridors), in order to understand their economic, socio-political, cultural and public health effects. As global road-building accelerates at an unprecedented rate, especially in the developing world, there is an urgent need for new models for understanding roads' potential economic benefits, as well as their risks, including their environmental risks. This project is benefitting citizens, NGOs, donors and governments, by generating new knowledge about how we have in the past, do at present, and should in the future, engage with roads.Read moreRead less
Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the ....Marsupial germ cells and genes. Germ cells are the most fascinating cells in the body, since theirs is the unique responsibility for transmitting life from generation to generation. Studies in mice have suggested that position in the embryo determines their origin, but the early embryology of the mouse is so different from that of other mammals that the events need confirming and extending in another species. The simplified embryology of the tammar wallaby makes it ideal for studying one of the most fundamental questions in the whole of biology: what is the basis for the primal distinction between sex and soma?Read moreRead less
Novel Methods For Promoting Organ Development And Growth
Funder
National Health and Medical Research Council
Funding Amount
$390,203.00
Summary
A revolutionary new therapy for treatment of growth restricted fetuses and premature babies is being developed through the administration of Colony Stimulating Factor (CSF-1). We have evidence that CSF-1 therapy can promote kidneys and lungs to continue development and maturation after birth. This exciting new finding allows for the application of CSF-1 therapy for both the treatment of premature babies and unborn babies with kidney defects.
Food allergies have emerged as a major public health concern affecting 1 in 10 Australian infants. Hospitals waiting times are in excess of 12-months for specialist services. Recent changes in the environment are driving up rates of food allergy but the mechanisms are unclear. Epigenetics is the science of how the environment influences gene behaviour. This fellowship will address the important and urgent question of how modern environments are changing our genes, leading to food allergy.
Measuring the impact of urban regulation on housing affordability in Australian cities and regions. Urban planning must ensure that development meets new environmental goals, but stringent regulation may reduce housing supply and affordability. This project uses new local planning data and econometric studies to quantify and monitor planning regulation impacts on housing supply and affordability in Australian cities and regions.
Promoting scientific literacy of secondary science students through studying socioscientific issues and argumentation. This project will develop a model of professional development and effective classroom strategies to improve 12-16 year old school students' decision-making about socioscientific issues. Key outcomes will be improved scientific literacy and willingness by young people to use scientific evidence when making personal and community decisions.
Einsteinian Physics: A new paradigm for school science. This project aims to determine whether the early teaching of the modern Einsteinian paradigm of physics improves students' understanding of physics and attitudes to science. The project aims to investigate whether it is feasible to teach all students the physics that underpins modern technology. It is expected that by introducing students to the paradigm of Einsteinian physics before they learn the useful Newtonian approximations, their eng ....Einsteinian Physics: A new paradigm for school science. This project aims to determine whether the early teaching of the modern Einsteinian paradigm of physics improves students' understanding of physics and attitudes to science. The project aims to investigate whether it is feasible to teach all students the physics that underpins modern technology. It is expected that by introducing students to the paradigm of Einsteinian physics before they learn the useful Newtonian approximations, their engagement and understanding of physics is intended to improve. This is critical to Australia as enrolments in the hard sciences plummet.Read moreRead less