Effects of prosthesis design on bone remodelling and longevity of dental restorations. The project targets both the 'Promoting and Maintaining Good Health' and 'Advanced Materials' designated research priority areas. The research will underpin Australia's leading role on some emerging interdisciplinary frontiers of biomechanics, biomaterials, health sciences and biomedical software. The development of computer aided clinical plan will help optimise dental restorations for 'long-term success'. Th ....Effects of prosthesis design on bone remodelling and longevity of dental restorations. The project targets both the 'Promoting and Maintaining Good Health' and 'Advanced Materials' designated research priority areas. The research will underpin Australia's leading role on some emerging interdisciplinary frontiers of biomechanics, biomaterials, health sciences and biomedical software. The development of computer aided clinical plan will help optimise dental restorations for 'long-term success'. The benefit will be to improve the ongoing performance and longevity of dental restoration, which complies with the highly demanding national goal of 'ageing well'. The study will also provide a new means to improve the therapy effect for many young Australians' effort towards a 'healthy start to their life'.Read moreRead less
Topography Optimisation of Implants for Enhancing Osseointegration. With recent increased life expectancy, the ratio of implant recipients to total population has dramatically increased. The project will address a critical issue in ensuring long-term success of prosthetic treatment. The proposed computational multiscale modelling will provide a sound scientific alternative means to optimisation of overall implant design including surface topography. The anticipated outcomes of this research will ....Topography Optimisation of Implants for Enhancing Osseointegration. With recent increased life expectancy, the ratio of implant recipients to total population has dramatically increased. The project will address a critical issue in ensuring long-term success of prosthetic treatment. The proposed computational multiscale modelling will provide a sound scientific alternative means to optimisation of overall implant design including surface topography. The anticipated outcomes of this research will help improve the quality of prosthetic therapy, and benefit our prosthodontic and orthopaedic professionals and their patients. The study clearly aligns with the national research goals of frontier technologies and maintaining good health.Read moreRead less
Nano-mechanical and nano-structural investigation of dentine: unravelling a novel nano-scale regulator of high durability of mineralised tissues. This project proposes that proteoglycans (PG) are key regulators of the high durability of dentine. PGs are primarily responsible for the structural organization of collagen in all vertebrates, however virtually nothing is known about their role on the biomechanics of mineralized tissues. This study aims to thoroughly address this question.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989859
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistr ....A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistry, research supported by this instrumentation will provide Australians with improvements to their dental health. Furthermore applications to industrial materials are providing Australian industries with better characterisation of their products that is leading to improved export performance and consequent improvement in Australia's balance of trade.Read moreRead less
Design Optimisation for Fabrication of Ceramic Prosthetic Devices. The project aims to develop computer aided design and fabrication for ceramic prosthesis. It will help establish a world-class biomedical instrumentation company having part of its research and development in Australia. The study will not only foster domestic research expertise, but also provide the local prosthetic community and biomedical industry with an opportunity to participate in further innovation of biomaterials, biomedi ....Design Optimisation for Fabrication of Ceramic Prosthetic Devices. The project aims to develop computer aided design and fabrication for ceramic prosthesis. It will help establish a world-class biomedical instrumentation company having part of its research and development in Australia. The study will not only foster domestic research expertise, but also provide the local prosthetic community and biomedical industry with an opportunity to participate in further innovation of biomaterials, biomedical software and equipment. The outcomes will directly benefit the Australian prosthetic profession. Improvement in prosthesis restorative longevity for our increasing ageing population will support the national research goal of ageing well, ageing productively.Read moreRead less
Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical ev ....Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites. This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.Read moreRead less
Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable ....Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable patients prone to orthodontic induced root resorption to be identified and also to assist with validating repair of enamel tooth structure in a non-surgical manner. It is anticipated to result in the development of a novel fibre optic instrument with applications beyond dentistry.
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Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Multiscale Study on Biomechanical Roles of Soft Tissue on Bone Remodelling. The project aims to increase our knowledge of the processes of bone remodelling and the role of soft tissue in this process. Mechanical force is a key stimulus for regulating bone remodelling. A significant question in biomechanics is why orthodontics only use very small forces (1 Newton) to generate significant oral bone remodelling, whereas prosthodontics that apply three orders of magnitude higher forces (~1000 Newton ....Multiscale Study on Biomechanical Roles of Soft Tissue on Bone Remodelling. The project aims to increase our knowledge of the processes of bone remodelling and the role of soft tissue in this process. Mechanical force is a key stimulus for regulating bone remodelling. A significant question in biomechanics is why orthodontics only use very small forces (1 Newton) to generate significant oral bone remodelling, whereas prosthodontics that apply three orders of magnitude higher forces (~1000 Newton) do not move dental implants. This project aims to develop new multiscale modelling and remodelling techniques in computational mechanics to explore the roles played by connective soft tissue in bone adaptation. Expected project outcomes would increase our understanding in biomechanics and affect health care disciplines such as orthodontics, prosthodontics and orthopaedics.Read moreRead less