In Vivo Tau Imaging In Alzheimer’s Disease And Other Dementias
Funder
National Health and Medical Research Council
Funding Amount
$538,998.00
Summary
Alteration of the normal protein tau leads to its deposition inside the brain cells leading to their death. These deposits have been well characterized and they are associated with cognitive impairment. We propose to study tau deposits in vivo in humans using positron emission tomography (PET) and assess its association with cognition and other signs of neurodegeneration
Apathy In Dementia: Identifying Mechanisms For Targeted Interventions
Funder
National Health and Medical Research Council
Funding Amount
$514,404.00
Summary
One of the most common symptoms in dementia is apathy - a reduction in concern, motivation or interest. Apathy impacts on a person’s ability to engage in necessary daily activities (e.g., cooking, washing, visiting friends) and often leads to people being placed in aged care facilities. This project will investigate the mechanisms which give rise to apathy in dementia. Understanding these mechanisms is the first step in developing new interventions to treat this challenging symptom.
Improving Service Provision For Early Onset Dementia: The INSPIRED Study
Funder
National Health and Medical Research Council
Funding Amount
$736,652.00
Summary
Early onset dementia (an onset of symptoms under the age of 65) is unexpected, distressing and can have devastating consequences for the person, their partner and children. People with early onset dementia face very different issues to older persons with the condition and do not fit in well with existing aged care services. The INSPIRED study will improve service delivery for younger people with dementia by ascertaining their numbers, burden, service experiences and needs.
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Functional Genomics Approach To Extend Lifespan While Preventing Age-related Cognitive Decline
Funder
National Health and Medical Research Council
Funding Amount
$772,600.00
Summary
In our ageing population, preventing age-related neurological decline is one of the central medical challenges of the 21st century. Here we use human population data obtained from people who reached 90 years of age free of any disease, or patients who suffer from dementia, combined with functional genomics studies in animals to pinpoint new genes that can be targeted to extend lifespan while preserving neurological function in these extended years of life.
Gene-environment Interactions Modulating Cognition And Dementia In Huntington’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$394,425.00
Summary
We are investigating mechanisms whereby cognitive symptoms, culminating in dementia, occur in a fatal brain disease, Huntington’s. We will explore how the ‘genetic stutter’ affects the brain at the level of molecules and cells, which will help identify targets for future treatment. We will also establish how environmental factors, including cognitive stimulation, physical activity and stress, modulate dementia. This will inform the development of treatments for this currently incurable disease.
Mutations In Ubiquitin Proteasome Pathway Genes As A Cause Of Frontotemporal Dementia And Motor Neuron Disease
Funder
National Health and Medical Research Council
Funding Amount
$639,860.00
Summary
This project aims to identify genes that are mutated in families affected with dementia and motor neuron disease, and to determine whether the same genes are responsible for disease in large collections of patients with similar disorders. Identifying these genes will reveal what biological processes can lead to brain and nerve cell degeneration, providing knowledge important for development of new treatments for the many people worldwide affected with these disorders.
Cognitive changes after surgery occur in the elderly, yet the cause remains unknown. We plan to study cognition in patients having hip surgery in which general and spinal anaesthesia are used together. This allows us to sample spinal fluid which will be analysed for substances which identify a predisposition to Alzheimer’s disease. By comparing the results to a group of subjects who have not undergone surgery, we hope to identify if anaesthesia and surgery exacerbate this predisposition.
A Randomised Cross-over Trial Of Family-mediated Personalised Activities For Nursing Home Residents With Dementia
Funder
National Health and Medical Research Council
Summary
While the cognitive, functional and behavioural changes in people with dementia are without doubt stressful for family carers, it may be that the loss of the relationship underlies the burden and feelings of depression that many carers experience. Typically, interventions to alleviate carer stress separate the carer from their relative instead of focusing on improving their relationship. This project aims to train carers to conduct personalised one-to-one activities with their relative.
Use Of Analgesics To Reduce Agitation And Agression In Older Persons With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$552,556.00
Summary
Understanding the causes of Behavioural and Psychological Symptoms of Dementia (BPSD) provides a potentially remedial target for interventions. The current study will undertake the first ever trial of analgesics to reduce the frequency of agitation/aggression and other BPSD. By completion we will have new insights into the relationship between pain and various sub-types of BPSD and robust evidence on the best class of analgesics to treat BPSD