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The Interplay Between IL-6 And GVHD On Anti-viral And Anti-leukaemic Immunity
Funder
National Health and Medical Research Council
Funding Amount
$489,376.00
Summary
Bone marrow transplantation can cure leukaemia but infection, graft-versus-host disease (GVHD) and leukaemia relapse remain challenging problems. We recently completed an early phase clinical study on GVHD prevention using interleukin-6 blockade. Interestingly, the rate of virus reactivation was also lower. This project will use a newly developed mouse model and stored clinical samples to understand the underlying mechanism and whether it also has an impact on anti-leukaemic immunity.