Methods To Improve Detail Reproduction Of Elastic Impression Materials
Funder
National Health and Medical Research Council
Funding Amount
$96,656.00
Summary
If a dental prosthesis is to fit precisely in the mouth, an accurate impression must be taken of the teeth and surrounding tissues. This research aims to evaluate variable surface conditions which may be taken into consideration to achieve an accurate impression, such as moisture, temperature, and the presence of contaminants. Although any distortions as a result of material interactions would be limited to the surface interface, inaccuracies here may ultimately compromise treatment success.
Schizophrenia is classified among the world’s top ten enduring disabilities. Hearing voices are a profound and distressing symptom, which have proven difficult to successfully treat. We plan to use the latest brain imaging techniques and genetic testing to develop the most comprehensive understanding of hearing for voices to date. These data are vital to the development of novel tailored treatment for patients who hear voices.
Study Of Motor Inhibition Deficits In Schizophrenia Using MRI, EventRelatedPotentialsand Transcranial Magnetic Stimulation
Funder
National Health and Medical Research Council
Funding Amount
$261,687.00
Summary
The aim of the proposed project is to study the neural mechanism underlying failures of motor-inhibition in patients with schizophrenia. The project will involve the use of fMRI and ERP measures during performance of a Stop-Signal Task, in order to explore the neural substrates of task performance in healthy subjects, and activational differences in schizophrenia patients. In a separate experimental session TMS will be applied in order to disrupt neural processing at cortical sites identified by ....The aim of the proposed project is to study the neural mechanism underlying failures of motor-inhibition in patients with schizophrenia. The project will involve the use of fMRI and ERP measures during performance of a Stop-Signal Task, in order to explore the neural substrates of task performance in healthy subjects, and activational differences in schizophrenia patients. In a separate experimental session TMS will be applied in order to disrupt neural processing at cortical sites identified by fMRI. Systematic use of TMS across different cortical sites will be used to compare effects of cortical site and subject group on task performance.Read moreRead less
Impact Of Somatic Versus Dendritic Inhibition On Neuronal Output
Funder
National Health and Medical Research Council
Funding Amount
$1,047,686.00
Summary
The brain is made up of literally billions of neurons connected in complex networks. These neurons come in two primary flavors - excitatory and inhibitory - which work in balance. Too much excitation and the brain becomes epileptic, too much inhibitory and we go into a coma. This proposal focuses on the role of specific inhibitory cell types in regulating brain function, and has relevant to a range of neurological disorders from epilepsy, to schizophrenia to depression.
Does CD123 Provide A Biological Advantage To Leukaemia Stem Cells?
Funder
National Health and Medical Research Council
Funding Amount
$647,637.00
Summary
Leukaemia is a devastating form of blood cancer affecting both young and old. We need to understand the diseased stem cell to eradicate this disease. Current therapy is poorly tolerated and the majority of patients ultimately die at relapse. We intend to investigate how we can make the cells more susceptible to therapy by understanding their biology.
Cytokine Signalling And The Regulation Of Normal And Leukaemic Blood Cells
Funder
National Health and Medical Research Council
Funding Amount
$948,684.00
Summary
The formation and actions of white blood cells are regulated by protein messengers called cytokines. Cytokines deliver their message by inducing the activation of signalling pathways that orchestrate the cell’s response to infection but when these responses occur too robustly or at inappropriate times they can lead to autoimmune disease, tissue damage and blood cancers. We study the naturally occurring feedback inhibitors of these processes in order to devise new treatments for these diseases.