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A Novel Physiological Role For Cytochrome P450 Enzymes In The Brain?
Funder
National Health and Medical Research Council
Funding Amount
$210,990.00
Summary
The cytochrome P450 enzymes in human liver have been traditionally regarded as drug metabolising enzymes. However, it is now becoming clear that they are distributed in other tissues in the body and that they may serve important and diverse roles in normal physiology. Little is known about their functions in the brain. We have identified a reaction catalysed by these enzymes that generates a chemical found in the brain normally, whose levels are elevated under stress and which, when given to ani ....The cytochrome P450 enzymes in human liver have been traditionally regarded as drug metabolising enzymes. However, it is now becoming clear that they are distributed in other tissues in the body and that they may serve important and diverse roles in normal physiology. Little is known about their functions in the brain. We have identified a reaction catalysed by these enzymes that generates a chemical found in the brain normally, whose levels are elevated under stress and which, when given to animals, is anxiogenic. This points to a possible involvement of P450 enzymes in a hitherto unexplored branch of the stress response. Importantly, it may lead to the development of novel drugs that block the P450 and therefore block production of the anxiogenic chemical. This proposal is designed to explore the basic biology underlying this system.Read moreRead less
Engineering CYP17A1 Inhibitors For Castrate-resistant Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$519,428.00
Summary
As prostate cancer progresses it becomes resistant to first line treatments and the current second line treatments have untoward side effects. This proposal will provide proof of principal for new selective drugs to be developed. We propose an innovative strategy to develop new selective drugs for the treatment of prostate cancer. This new therapeutic approach will identify new compounds for patients specifically with castrate sensitive and resistant prostate cancer.