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Mucous In Heterogeneous And Progressive Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$347,948.00
Summary
Cystic fibrosis (CF) is the most common genetically acquired, life-shortening chronic illness affecting young Australians today. Individuals with CF have a reduced ability to clear mucous from the airways resulting in respiratory infections and inflammation. This project will quantify the biochemical and biophysical properties of mucous in young children with CF to generate novel insights into the pathogenesis of early disease, biomarkers of disease progression and therapeutic targets.
The Importance Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung disease is a lifelong problem for people with cystic fibrosis (CF). Blood immune cells called neutrophils swarm the lung and cause ongoing damage. No treatments exist because how CF lungs talk to neutrophils is poorly understood. I will apply new skills from an international neutrophil expert to study samples from AREST CF, a world leading CF research group. This unique combination will recreate the early CF lung in the laboratory, testing triggers of CF lung disease and potential drugs.
Acquisition And Transmission Of Respiratory Pathogens In Persons With Cystic Fibrosis (CF): Development And Implementation Of Novel Molecular Tools
Funder
National Health and Medical Research Council
Funding Amount
$155,416.00
Summary
There are a number of significant bacteria that cause infection in children with cystic fibrosis. Early eradication may have a positive impact on clinical outcome. Molecular biology assists in the rapid identification and characterisation of clinical strains of these bacteria. This project will develop molecular biology tools and then use them to pimporve detection of these significant bacteria in early childhood of people with CF.
Structural And Functional Imaging In Paediatric Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung imaging is an important part of the clinical care of young patients with respiratory disease. However, the most used method at the moment is computed tomography (CT), which exposes the patient to radiation. One potential radiation-free alternative to CT is lung magnetic resonance imaging (MRI). This project will investigate how well lung MRI performs clinically in two important childhood diseases: cystic fibrosis, and preterm birth.
Understanding And Preventing Airborne Transmission Of Infectious Respiratory Aerosols
Funder
National Health and Medical Research Council
Funding Amount
$393,894.00
Summary
This project aims to significantly advance our understanding of how infectious bacteria are transmitted through the air, and what basic control measures are most effective at preventing this. This research is focused on persons with cystic fibrosis (CF), as they may be particularly susceptible to such transmission, but our results will also help us better understand how other infections are spread through the air. This is especially important given the recent global influenza pandemic.