Nanostructured Degradable Polymer for Drug Delivery. The success of synthesising nanostructured degradable polymers will position Australia at the world forefront in the field of nanotechnology, bioengineering and healthcare sectors in both fundamental and applied research. This multi-disciplinary research has the potential to generate patentable technologies with economic benefits to Australia. The project also involves fundamental research into surface chemistry, nanostructure, polymer science ....Nanostructured Degradable Polymer for Drug Delivery. The success of synthesising nanostructured degradable polymers will position Australia at the world forefront in the field of nanotechnology, bioengineering and healthcare sectors in both fundamental and applied research. This multi-disciplinary research has the potential to generate patentable technologies with economic benefits to Australia. The project also involves fundamental research into surface chemistry, nanostructure, polymer sciences and will be a meaningful contribution to the advancement of scientific knowledge in Australia. All these will enhance the international competitive profile of Australia in the field of nanotechnology for drug delivery.Read moreRead less
Integrated self assembly processes and spinning disc reactor technology. Spinning Disc Reactor technology is new to Australia and will have wide ranging applications in nano-technology and in developing benign industrial chemical processes with smaller footprint and significantly reduced capital outlay. The cutting edge research will foster collaboration with industry, and lead to establishing new industries in device technology, smart materials, health care products, catalysis and energy storag ....Integrated self assembly processes and spinning disc reactor technology. Spinning Disc Reactor technology is new to Australia and will have wide ranging applications in nano-technology and in developing benign industrial chemical processes with smaller footprint and significantly reduced capital outlay. The cutting edge research will foster collaboration with industry, and lead to establishing new industries in device technology, smart materials, health care products, catalysis and energy storage, through exploiting commercial opportunities. The project will provide excellent research training in a range of scientific skills and in professional development, and will involve overseas PhD exchange programs. The exciting research incorporating benign metrics will enhance public opinion towards science. Read moreRead less
Optimisation of pigment coating surface treatments. Control and optimisation of surface coatings in pigment processing will lead to improved production efficiency and quality. In pigment processing, technology developed in this project may not only save millions of dollars in increased production efficiency but also lead to improved pigment optical performance in pigment applications such as paints, plastics and pharmaceuticals.
Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively ....Allosteric Enhancers: Leads for the Therapy of Cardiovascular Disease. Cardiovascular disease (CVD - heart, stroke and blood vessel disease) kills more people each year than cancer, AIDS and traffic accidents combined. Coronary heart disease (CHD), followed by stroke, is the largest single cause of death in Australia. Allosteric enhancers are particularly attractive drug targets for the prevention of CVD due to their ability to limit injury associated with ischaemic tissue trauma selectively in tissues where adenosine is elevated. Whilst the development of drugs that protect against heart attack and stroke is a difficult and long term objective, any advances toward this goal would clearly be of great benefit to the community.Read moreRead less
POLYMER-BASED COATINGS TO INCREASE THE SURVIVAL OF MICROBIAL INOCULANTS APPLIED TO AGRICULTURAL SEEDS. World-wide, there is much active research to maximise the use of Rhizobium for legumes and to develop a new range of growth-promoting micro-organisms for application to agricultural crops including cereals. However, very poor survival of inoculant bacteria after application to seed severely limits their effectiveness. New polymer coatings on seed may enhance survival of inoculants. By collabora ....POLYMER-BASED COATINGS TO INCREASE THE SURVIVAL OF MICROBIAL INOCULANTS APPLIED TO AGRICULTURAL SEEDS. World-wide, there is much active research to maximise the use of Rhizobium for legumes and to develop a new range of growth-promoting micro-organisms for application to agricultural crops including cereals. However, very poor survival of inoculant bacteria after application to seed severely limits their effectiveness. New polymer coatings on seed may enhance survival of inoculants. By collaboration between chemists, rhizobiologists and the inoculant and seed-coating industries, innovative technology can now be generated, improving inoculum potential, giving higher crop yields using less fertilisers. The technology will generate a rural service industry providing coated seed products that reduce farmers' input costs and help maximise their income.Read moreRead less
Synthesis of Novel Dual Acting, Selenium Containing Antioxidants. Ischemic heart disease and chronic inflammation afflict a large segment of the Australian population, especially the ageing. These states are associated with free-radicals and other reactive oxygen species and can be controlled to some extent by the application of adenosine therapy. This project will combine the activity of adenosine agonists and enhancers with selenium-containing antioxidants, used to quench reactive oxygen spe ....Synthesis of Novel Dual Acting, Selenium Containing Antioxidants. Ischemic heart disease and chronic inflammation afflict a large segment of the Australian population, especially the ageing. These states are associated with free-radicals and other reactive oxygen species and can be controlled to some extent by the application of adenosine therapy. This project will combine the activity of adenosine agonists and enhancers with selenium-containing antioxidants, used to quench reactive oxygen species, to provide a powerful new class of pharmaceutical products designed to enhance the quality of life of Australians afflicted by diseases propagated by free-radicals.Read moreRead less
Elucidation of genetic and physiological factors controlling biosynthesis of sesquiterpenoids in sandalwood, Santalum spp. Plantation sandalwood removes pressure from natural populations and is a profitable long term investment. Australia is in a highly competitive position with regards to market supply but this cannot be taken for granted. This research seeks to understand the complex biology of sandalwood using the latest genomic and molecular technologies. This knowledge will be applied thro ....Elucidation of genetic and physiological factors controlling biosynthesis of sesquiterpenoids in sandalwood, Santalum spp. Plantation sandalwood removes pressure from natural populations and is a profitable long term investment. Australia is in a highly competitive position with regards to market supply but this cannot be taken for granted. This research seeks to understand the complex biology of sandalwood using the latest genomic and molecular technologies. This knowledge will be applied through directed, marker-assisted tree selection and improved plantation management. Ultimately we are developing a highly advanced production system with which Australia can lead Sandalwood production. Sandalwood plantations use a variety of native perennial hosts, increase biodiversity, help manage underground water resources and address carbon sequestration demands.Read moreRead less
Stabilisation of Titania Pigment Slurries During Processing. This project aims to improve the stabilisation properties of titania pigment slurries during production. Current polyphosphate dispersants used by Tiwest are unstable under processing conditions. Tailored, robust dispersing reagents will therefore be investigated in order to provide improved stabilisation of pigments during processing. Enhanced understanding of the dispersing reagents interaction with the titania pigment surface and th ....Stabilisation of Titania Pigment Slurries During Processing. This project aims to improve the stabilisation properties of titania pigment slurries during production. Current polyphosphate dispersants used by Tiwest are unstable under processing conditions. Tailored, robust dispersing reagents will therefore be investigated in order to provide improved stabilisation of pigments during processing. Enhanced understanding of the dispersing reagents interaction with the titania pigment surface and the subsequent stability of the pigment will allow advances in processing and consequently improved final products. The potential growth in market share, by improved product performance, is in excess of $50M pa.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide ....Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.Read moreRead less