Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Integrated composite electrodes for electrochemical synthesis of ammonia. This project aims to develop multifunctional composite electrodes for electrochemical synthesis of ammonia from water, nitrogen gas and renewable energy under ambient conditions. Hydrophobic subnanometre water channels will be integrated with an electrocatalyst to control supply of water as vapour, thereby effectively minimising hydrogen evolution reaction and enabling high-efficiency ammonia synthesis. Expected outcomes i ....Integrated composite electrodes for electrochemical synthesis of ammonia. This project aims to develop multifunctional composite electrodes for electrochemical synthesis of ammonia from water, nitrogen gas and renewable energy under ambient conditions. Hydrophobic subnanometre water channels will be integrated with an electrocatalyst to control supply of water as vapour, thereby effectively minimising hydrogen evolution reaction and enabling high-efficiency ammonia synthesis. Expected outcomes include enhanced capacity in developing electrochemical reaction systems, and new fundamental knowledge of electrocatalyst design and reaction engineering. This should provide significant economic and environmental benefits by developing a sustainable manufacturing technology to transform the century-old ammonia industry.Read moreRead less
Nanoarchitectured anti-corrosion coatings for zinc-plated steel. Zinc-plated steel is widely used in buildings, households and vehicles, but the long-term performance is limited due to corrosion resulting from exposure to high humidity or alkaline conditions. Currently, available chromium coatings are toxic, while polymeric coatings lack durability. This project aims to use nanotechnology to develop highly effective, multifunctional anti-corrosive coatings in which long-term protection is achiev ....Nanoarchitectured anti-corrosion coatings for zinc-plated steel. Zinc-plated steel is widely used in buildings, households and vehicles, but the long-term performance is limited due to corrosion resulting from exposure to high humidity or alkaline conditions. Currently, available chromium coatings are toxic, while polymeric coatings lack durability. This project aims to use nanotechnology to develop highly effective, multifunctional anti-corrosive coatings in which long-term protection is achieved by controlling the wettability and self-healing properties. The project is excepted to generate new knowledge in coating materials that limit corrosion and address environmental problems. This advanced manufacturing technology should be of high-value benefit to manufacturers and consumers of zinc-plated steel.Read moreRead less
Physics-informed Computational Framework for Optimised Microfluidic Systems. The miniaturisation of chemical and biological processes requires microfluidic tools for the precise manipulation of complex fluids at the microscale. This project aims to integrate new computational methods that enable unprecedented control over the design and optimisation of these tools. The project will deliver a cornerstone framework to elucidate the complex microscopic fluid physics that currently poses a challenge ....Physics-informed Computational Framework for Optimised Microfluidic Systems. The miniaturisation of chemical and biological processes requires microfluidic tools for the precise manipulation of complex fluids at the microscale. This project aims to integrate new computational methods that enable unprecedented control over the design and optimisation of these tools. The project will deliver a cornerstone framework to elucidate the complex microscopic fluid physics that currently poses a challenge for the advancement of microfluidic technologies. The outcomes of this project will establish physical principles to guide the design of microfluidic systems and provide the computational capabilities that can potentially transform the way researchers and engineers design, optimise and use microfluidic technologies.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100023
Funder
Australian Research Council
Funding Amount
$4,943,949.00
Summary
ARC Training Centre in Bioplastics and Biocomposites. There is unprecedented growth in demand for bioderived and biodegradable materials. This Training Centre in Bioplastics and Biocomposites will capitalise on Australia’s abundance of the requisite natural bioresources to drive advances in technology for the development of bioplastic and biocomposite products for the new bioeconomy. The aim is to deliver leading edge research with a holistic focus on technical, social, policy and end of life so ....ARC Training Centre in Bioplastics and Biocomposites. There is unprecedented growth in demand for bioderived and biodegradable materials. This Training Centre in Bioplastics and Biocomposites will capitalise on Australia’s abundance of the requisite natural bioresources to drive advances in technology for the development of bioplastic and biocomposite products for the new bioeconomy. The aim is to deliver leading edge research with a holistic focus on technical, social, policy and end of life solutions, training a cohort of industry ready research specialists to underpin Australia’s transition to a globally significant bioplastics and biocomposites industry, while at the same time laying the foundations for accelerated growth in this space.Read moreRead less
Engineered nanoporous materials and composites having hierarchical structures by emulsion templating. The project aims to develop new and flexible emulsion-templated processes capable of constructing novel nanoporous materials with hierarchical structures. The project has the potential to revolutionise current approaches for making porous materials, and the outcomes will enhance Australia's ability in frontier technologies and advanced materials.
Intracellular manufacturing - high performance biomaterials from methane. The aim of this project is to produce high performance biodegradable polymers directly from methane. The key innovation is employing cutting-edge community genomic and transcriptomic approaches to characterise intracellular production lines in order to tailor polyhydroxybutyrate-co-valerate (PHBV) copolymer microstructures. This is a truly multidisciplinary project bringing together engineers, polymer scientists and molecu ....Intracellular manufacturing - high performance biomaterials from methane. The aim of this project is to produce high performance biodegradable polymers directly from methane. The key innovation is employing cutting-edge community genomic and transcriptomic approaches to characterise intracellular production lines in order to tailor polyhydroxybutyrate-co-valerate (PHBV) copolymer microstructures. This is a truly multidisciplinary project bringing together engineers, polymer scientists and molecular biologists. It is expected that a direct outcome of the project will be the first PHBV copolymer from methane. As such, the project aims to develop technology for the production of tough, flexible and affordable biopolymers and, at the same time, provide an opportunity to add value to methane.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100084
Funder
Australian Research Council
Funding Amount
$269,020.00
Summary
Flexible Flame Aerosol Synthesis Technology. Funding is requested to establish a world-leading fabrication facility for nanostructured materials via flame synthesis. This is a scalable fabrication route used for industrial production of most nanoparticle commodities. The aim is to advance current capabilities by providing control over the reaction environment and flame reaction sources. This will extend the range of feasible materials from the current metal oxides to a broad family of nitrides, ....Flexible Flame Aerosol Synthesis Technology. Funding is requested to establish a world-leading fabrication facility for nanostructured materials via flame synthesis. This is a scalable fabrication route used for industrial production of most nanoparticle commodities. The aim is to advance current capabilities by providing control over the reaction environment and flame reaction sources. This will extend the range of feasible materials from the current metal oxides to a broad family of nitrides, sulphides, and metal-organic frameworks, enabling the engineering of electrocatalysts, optoelectronic- and bio-materials. Benefits are expected in terms of fundamental and applied knowledge generation, with impact to the Australian industry sectors of Advanced Manufacturing, Energy and Health.Read moreRead less