Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological ro ....Fungal Ribosomally Synthesised and Post-translationally Modified Peptides. Fungi produce an array of molecules called secondary metabolites (SMs) that impact on everyday life (e.g. penicillin). This project aims to investigate a new class of fungal peptide SMs called RiPPs which are structurally unique from existing molecules and offer the exciting prospect of harbouring new and novel biological activities. This project expects to discover the mechanisms of RiPP synthesis and their biological roles in plant pathogenic fungi, and uncover and engineer novel RiPPs with desired bioactivities. The expected outcome from this project will be a seminal advance in fungal SM biology which should provide significant benefits through the generation of exciting new lead molecules for the agricultural and medical industries.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100022
Funder
Australian Research Council
Funding Amount
$4,787,259.00
Summary
ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop pr ....ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop protection. An expert multidisciplinary team uniting science, commercial and social licence pathways ensures industry and consumer uptake advancing $60B Australian Agriculture. The Hub translates to increased productivity, market access and enhanced environmental credentials of Australian food.
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Industrial Transformation Training Centres - Grant ID: IC150100026
Funder
Australian Research Council
Funding Amount
$3,732,019.00
Summary
ARC Training Centre for Fruit Fly Biosecurity Innovation. ARC Training Centre for Fruit Fly Biosecurity Innovation. This training centre aims to transform the way that horticulture industries combat invasive fruit flies that threaten Australian crops, which are valued at $9 billion per year. For generations, Australia has relied on insecticides to protect crops. Owing to environmental damage and concerns for consumer health, the most effective insecticides have recently been banned for use on ma ....ARC Training Centre for Fruit Fly Biosecurity Innovation. ARC Training Centre for Fruit Fly Biosecurity Innovation. This training centre aims to transform the way that horticulture industries combat invasive fruit flies that threaten Australian crops, which are valued at $9 billion per year. For generations, Australia has relied on insecticides to protect crops. Owing to environmental damage and concerns for consumer health, the most effective insecticides have recently been banned for use on many crops leaving no equivalent replacements. Horticulture industries are unprepared for this change, and are in desperate need of new sustainable practices to combat fruit flies. New researchers who are trained in both scientific approach and practical application will be well placed to deliver these new tools.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100006
Funder
Australian Research Council
Funding Amount
$4,933,330.00
Summary
ARC Research Hub for Engineering Plants to Replace Fossil Carbon . This Hub aims to develop new plant varieties that enable sustainable production of sugars from crop ‘waste’ (plant biomass) as a base for renewable carbon products. Only now possible through emerging technologies, the Hub expects to translate extensive foundational research and world-leading expertise into cost-effective sustainable aviation fuel. Anticipated outcomes include diversified cropping opportunities for agricultural pr ....ARC Research Hub for Engineering Plants to Replace Fossil Carbon . This Hub aims to develop new plant varieties that enable sustainable production of sugars from crop ‘waste’ (plant biomass) as a base for renewable carbon products. Only now possible through emerging technologies, the Hub expects to translate extensive foundational research and world-leading expertise into cost-effective sustainable aviation fuel. Anticipated outcomes include diversified cropping opportunities for agricultural producers and new industries to convert the biomass to high-volume renewable products. The expected benefits include a decarbonised pathway for Australia’s critical flight, freight and defence connections to world and the substantial economic returns and job creation from new manufacturing capacity in Australia.Read moreRead less
Cereal blueprints for a water-limited world. This project aims to demonstrate that key developmental genes in cereals can be manipulated to design plant architecture for specific resource-limited environments. Producing more food with less water is one of the greatest challenges facing humanity today. This project expects to increase understanding of how shoot and root systems can be uncoupled to enhance crop adaptation in water-limited environments using an accelerated genome editing approach. ....Cereal blueprints for a water-limited world. This project aims to demonstrate that key developmental genes in cereals can be manipulated to design plant architecture for specific resource-limited environments. Producing more food with less water is one of the greatest challenges facing humanity today. This project expects to increase understanding of how shoot and root systems can be uncoupled to enhance crop adaptation in water-limited environments using an accelerated genome editing approach. An expected outcome of the project is enhanced drought adaptation for cereals in a dry world. This should provide significant benefits to farmers and consumers in Australia and worldwide.Read moreRead less
Preventing and addressing environmental harm through restorative justice. This project aims to develop a knowledge base on how Restorative Justice (RJ) principles and practices can prevent and address environmental harm. Research has demonstrated that RJ is a powerful response to a wide variety of governance challenges and could provide a useful alternative paradigm for environmental regulation. This project aims to apply the processes and values of RJ to environmental regulation with a focus on ....Preventing and addressing environmental harm through restorative justice. This project aims to develop a knowledge base on how Restorative Justice (RJ) principles and practices can prevent and address environmental harm. Research has demonstrated that RJ is a powerful response to a wide variety of governance challenges and could provide a useful alternative paradigm for environmental regulation. This project aims to apply the processes and values of RJ to environmental regulation with a focus on harm prevention, advancing theory into a new domain of application. This should lead to immediate and long-term benefits, including better prevention of environmental harm, better relationships with communities, and stronger commitments by those who have caused harm to rehabilitate, repair and reform.Read moreRead less
Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to ....Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to accelerate breeding for diverse production environments, with direct applications in barley, and other major cereals including wheat and oats. This should provide significant economic and social benefits to the Australian grains industry through yield stability amidst climate variability.Read moreRead less
CropVision: A next-generation system for predicting crop production. Accurate and timely production estimates are essential to Australia’s grain producers and industry to better deal with down side risk caused by climate extremes and market volatilities. However, current systems for predicting crop production are inaccurate and unreliable. This project aims to develop a next generation system for advance and high accuracy predictions for yield, crop type and area at field scale. This will be don ....CropVision: A next-generation system for predicting crop production. Accurate and timely production estimates are essential to Australia’s grain producers and industry to better deal with down side risk caused by climate extremes and market volatilities. However, current systems for predicting crop production are inaccurate and unreliable. This project aims to develop a next generation system for advance and high accuracy predictions for yield, crop type and area at field scale. This will be done by integrating the state of the art global climate models (GCM), biophysical crop modelling, and high-resolution earth observation technologies. This project will deliver a next generation crop prediction system to predict crop production at field scale for improved decision-making and enhancing resilience.Read moreRead less
Molecular mechanisms of signalling by plant immune receptors. This project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from ....Molecular mechanisms of signalling by plant immune receptors. This project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from sexually compatible species and short effective time spans in the field. Building on previous research, this project aims to characterise the molecular basis of the Toll/interleukin-1 receptor domain-mediated nicotinamide adenine dinucleotide (NAD+) cleavage and the structural architecture of plant NLR complexes. This knowledge will support the long-term objective of protecting crops from pathogens.Read moreRead less
Structural basis of plant immune receptor signaling. Plants detect invading pathogens and trigger immune responses in a process called “effector-triggered immunity”, in which pathogen effector (avirulence) proteins are recognized by plant resistance proteins, typically so-called “plant NLRs”. Ongoing work in the applicants’ laboratories has shown that oligomerization into “resistosomes” and NAD+ (nicotinamide adenine dinucleotide) cleavage play central roles in the process. Building on these dat ....Structural basis of plant immune receptor signaling. Plants detect invading pathogens and trigger immune responses in a process called “effector-triggered immunity”, in which pathogen effector (avirulence) proteins are recognized by plant resistance proteins, typically so-called “plant NLRs”. Ongoing work in the applicants’ laboratories has shown that oligomerization into “resistosomes” and NAD+ (nicotinamide adenine dinucleotide) cleavage play central roles in the process. Building on these data, the project aims to characterize the structures of the signaling molecules resulting from TIR (Toll/interleukin-1 receptor) domain-mediated NAD+ cleavage and the structural architecture of plant NLR resistosomes. This knowledge will support the long-term objective of protecting crops from pathogens.Read moreRead less