Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Breast Cancer is a very common disease in women and although huge progress has been made in the last two decades, much remains to be done to improve our understanding of different types of breast cancer and its management. This program brings together the expertise of three senior researchers: 2scientists and 1 medical scientist. Dr Trench has an interest in identifying genes involved in cancers arising in patients who have a strong family history. She will use molecular methods and cohorts of p ....Breast Cancer is a very common disease in women and although huge progress has been made in the last two decades, much remains to be done to improve our understanding of different types of breast cancer and its management. This program brings together the expertise of three senior researchers: 2scientists and 1 medical scientist. Dr Trench has an interest in identifying genes involved in cancers arising in patients who have a strong family history. She will use molecular methods and cohorts of patients enrolled with Kathleen Cunningham Foundation for Research into Familial Breast and Ovarian Cancer to identify the genes responsible, assess their distribution in the population and determine whether these genes also play a role in non-familial cancers. Dr Khanna's work examines the complex array of enzymes that are responsible for maintaining the integrity of the DNA, and investigates how failure of these mechanisms leads to damage of the genetic material which ultimately results in cancer. It is known that genes involved in familial predisposition code for proteins that work as DNA repair enzymes. It is also known that different types of breast cancer exist, each with differing behaviour and response to treatment and that they are associated with specific genetic changes, including those associated with a familial predisposition. Prof Lakhani's interest lies in using microscopy and the latest molecular tools to refine the classification of these different types of breast tumour so that they can be managed appropriately by his surgical and oncological colleagues. A better understanding of the genetic changes and underlying biology of different types of breast cancer will lead to individualised and specific therapy for patients. This program brings together a unique combination, nationally and internationally, that investigates cancers at the level of genes and cells and translates the information to the clinic for the benefit of patient management.Read moreRead less
Factors Contributing To Socioeconomic Gradients In Children's Oral Health Between 1993 And 2003
Funder
National Health and Medical Research Council
Funding Amount
$79,532.00
Summary
The NHMRC and the Australian National Oral Health Plan have identified health inequalities as a critical health issue. Dental caries in children increasingly has become concentrated in disadvantaged population groups. While previous studies have documented socioeconomic gradients in oral health, few have sought to explain the reasons underlying those inequalities. By taking advantage of two existing datasets of child oral health in Australia, collected in 1992 and 2002, we will be able to quanti ....The NHMRC and the Australian National Oral Health Plan have identified health inequalities as a critical health issue. Dental caries in children increasingly has become concentrated in disadvantaged population groups. While previous studies have documented socioeconomic gradients in oral health, few have sought to explain the reasons underlying those inequalities. By taking advantage of two existing datasets of child oral health in Australia, collected in 1992 and 2002, we will be able to quantify change in socioeconomic inequalities in oral health, and identify population-wide exposures to preventive practices and social circumstances that may have contributed to that change.Read moreRead less
Spatially Targeted Intervention For Eliminating Tuberculosis In High-burden Countries
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The overall goal of my research program is to design and implement an innovative approach for eliminating TB in high-burden countries such as Ethiopia and China. My project will integrate contemporary and sophisticated analytical methods (geospatial methods, network meta-analysis and economic analysis) within a single translational research framework and provide evidence to make a substantial shift from the current paradigm of passive case detection.
Elucidating Genetic Mechanisms Responsible For Familial Hyperaldosteronism Type II
Funder
National Health and Medical Research Council
Funding Amount
$424,812.00
Summary
Primary aldosteronism (PAL) is the commonest specifically treatable and potentially curable form of hypertension (high blood pressure), a common disease, expensive to treat, with serious morbidity and mortality. This project will use cutting edge technology to gain new knowledge concerning how genes regulate the body's production of aldosterone (salt hormone), which will help us understand how PAL develops and how common it is, and could lead to better approaches to diagnosis and treatment.