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Research Topic : Copy Number Variations
Field of Research : Numerical and Computational Mathematics
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  • Funded Activity

    Discovery Projects - Grant ID: DP1097023

    Funder
    Australian Research Council
    Funding Amount
    $735,000.00
    Summary
    Algebraic methods for Markov Chain Monte Carlo and quasi-Monte Carlo. In an increasingly complex world, the requirements on computational methods for solving real world problems from areas like statistics, finance, economics, physics and others are also constantly increasing. The results from this project will significantly improve existing computational methods, thereby helping to solve existing computational challenges and further strengthening Australia's reputation as a leading scientific lo .... Algebraic methods for Markov Chain Monte Carlo and quasi-Monte Carlo. In an increasingly complex world, the requirements on computational methods for solving real world problems from areas like statistics, finance, economics, physics and others are also constantly increasing. The results from this project will significantly improve existing computational methods, thereby helping to solve existing computational challenges and further strengthening Australia's reputation as a leading scientific location. The research carried out will be in collaboration with international experts, creating and strengthening existing ties of Australian research institutions with other world class research institutes overseas.
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    Funded Activity

    Discovery Projects - Grant ID: DP0985765

    Funder
    Australian Research Council
    Funding Amount
    $255,000.00
    Summary
    High dimensional problems of integration and approximation. In many applications, notably financial mathematics, problems of integration and approximation of functions in very high dimensions are of great interest. By finding modern mathematical solutions to these problems, we will therefore contribute to Australia's future success in developing innovative technologies for industrial and economic applications. By researching at an internationally competitive level and by cooperating with i .... High dimensional problems of integration and approximation. In many applications, notably financial mathematics, problems of integration and approximation of functions in very high dimensions are of great interest. By finding modern mathematical solutions to these problems, we will therefore contribute to Australia's future success in developing innovative technologies for industrial and economic applications. By researching at an internationally competitive level and by cooperating with international experts, we will have a share in further strengthening the excellent role of Australian research institutions within the international scientific community in mathematics and scientific computing.
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    Funded Activity

    Discovery Projects - Grant ID: DP0451168

    Funder
    Australian Research Council
    Funding Amount
    $150,000.00
    Summary
    A comparative study of generalised solution concepts for elliptic partial differential equations using nonsmooth analysis techniques. The solution of ellpitic partial differential equations is central to science and engineering. There are a number of solution concepts, such as those of weak solutions and viscosity solutions, but the relations between these are incompletely understood. We shall investigate this major question using recent advances in optimisation theory and nonsmooth analysis. .... A comparative study of generalised solution concepts for elliptic partial differential equations using nonsmooth analysis techniques. The solution of ellpitic partial differential equations is central to science and engineering. There are a number of solution concepts, such as those of weak solutions and viscosity solutions, but the relations between these are incompletely understood. We shall investigate this major question using recent advances in optimisation theory and nonsmooth analysis. Our approach is to use various approximations and their associated second-order subdifferentials, each of which implies a generalised solution concept and associated abstract convexity. Particular attention, including computational details, will be given to equations which have very different solutions of one type from those of another.
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    Funded Activity

    ARC Future Fellowships - Grant ID: FT130100038

    Funder
    Australian Research Council
    Funding Amount
    $606,300.00
    Summary
    A New Optimization Approach for Tensor Extreme Eigenvalue Problems: Modern Techniques for Multi-relational Data Analysis. Nowadays, we often encounter complex multi-relational data whose objects have interactions among themselves based on different relations. These multi-relational data can be mathematically modelled as tensors. The tensor extreme eigenvalue problem, which is concerned with extracting the most significant qualitative information from multi-relational data, plays a key role in m .... A New Optimization Approach for Tensor Extreme Eigenvalue Problems: Modern Techniques for Multi-relational Data Analysis. Nowadays, we often encounter complex multi-relational data whose objects have interactions among themselves based on different relations. These multi-relational data can be mathematically modelled as tensors. The tensor extreme eigenvalue problem, which is concerned with extracting the most significant qualitative information from multi-relational data, plays a key role in modern data analysis. This project aims at developing innovative global optimisation frameworks and reliable numerical methods for tensor extreme eigenvalue problems, and applying the proposed methods to solve various practical problems arising from important application areas such as modern data analysis, medical imaging science and signal processing.
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    Funded Activity

    Discovery Projects - Grant ID: DP1093769

    Funder
    Australian Research Council
    Funding Amount
    $555,000.00
    Summary
    Computer Assisted Research Mathematics and its Applications. The mathematics community will benefit from infusion of new computer-assisted techniques and modalities for research and training post-graduate students, both from my pure research project and through development of an associated research centre. Ultimately, this should also help more school students learn mathematics well and so play a part in addressing Australia's skill shortage. Also, the work on optimization algorithms promises to .... Computer Assisted Research Mathematics and its Applications. The mathematics community will benefit from infusion of new computer-assisted techniques and modalities for research and training post-graduate students, both from my pure research project and through development of an associated research centre. Ultimately, this should also help more school students learn mathematics well and so play a part in addressing Australia's skill shortage. Also, the work on optimization algorithms promises to improve the performance and quality of many practical signal reconstruction methods. These are used by varied Australian industries from telecommunication to mining and by researchers in the digital arts and fields such as astronomy, physics, chemistry, bioscience, geoscience, engineering and medicine.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP190100555

    Funder
    Australian Research Council
    Funding Amount
    $330,000.00
    Summary
    Innovations in sparse optimisation: big data nonsmooth optimisation. This project aims to produce innovative optimisation methods capable of solving a wide range of practical problems that are currently too complex to be solved. Optimisation involving huge data sets is ubiquitous. Sparse optimisation has emerged as a challenging frontier of modern optimisation because it effectively computes an optimal solution with desired low complexity structure so that a resulting solution can be efficiently .... Innovations in sparse optimisation: big data nonsmooth optimisation. This project aims to produce innovative optimisation methods capable of solving a wide range of practical problems that are currently too complex to be solved. Optimisation involving huge data sets is ubiquitous. Sparse optimisation has emerged as a challenging frontier of modern optimisation because it effectively computes an optimal solution with desired low complexity structure so that a resulting solution can be efficiently stored, implemented and utilised, and is robust to the data inexactness. This project aims at developing innovative mathematical techniques and efficient numerical schemes for solving sparse optimisation problems. The intended outcomes will have significant impact on many areas of science, medicine and engineering, where sparse optimisation is used, including cancer radiotherapy optimal planning.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP160100854

    Funder
    Australian Research Council
    Funding Amount
    $199,215.00
    Summary
    Stability of Generalised Equations and Variational Systems. This project seeks to advance a new mathematical theory of variational analysis which may lead to applications in optimisation. The emphasis will be on extensions of regularity concepts appropriate for studying stability (the ‘radius of good behaviour’) of solutions to optimisation problems, particularly those of semi-infinite optimisation and programs with equilibrium constraints, when standard assumptions are not satisfied. The expect .... Stability of Generalised Equations and Variational Systems. This project seeks to advance a new mathematical theory of variational analysis which may lead to applications in optimisation. The emphasis will be on extensions of regularity concepts appropriate for studying stability (the ‘radius of good behaviour’) of solutions to optimisation problems, particularly those of semi-infinite optimisation and programs with equilibrium constraints, when standard assumptions are not satisfied. The expected outcomes may have an impact in enhancing the convergence of numerical methods and facilitating the post-optimal analysis of solutions. It may also generate new tools for increasing efficiencies and cost reductions in engineering, logistics, economics, financial systems, and environmental science.
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    Funded Activity

    Discovery Projects - Grant ID: DP120100567

    Funder
    Australian Research Council
    Funding Amount
    $390,000.00
    Summary
    Structured barrier and penalty functions in infinite dimensional optimisation and analysis. Very large scale tightly-constrained optimisation problems are ubiquitous and include water management, traffic flow, and imaging at telescopes and hospitals. Massively parallel computers can solve such problems and provide physically realisable solution only if subtle design issues are mastered. Resolving such issues is the goal of this project.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP160101537

    Funder
    Australian Research Council
    Funding Amount
    $564,979.00
    Summary
    Relaxed reflection methods for feasibility and matrix completion problems. The project proposes to further develop the non-linear convergence theory, and to provide problem-specific implementations. Many applied and pure problems require solution of a large set of linear or nonlinear equations (or inequalities). Highly effective, parallelisable methods are based on iterated projection or reflection algorithms which aggregate information about individual equations. The theory is well developed in .... Relaxed reflection methods for feasibility and matrix completion problems. The project proposes to further develop the non-linear convergence theory, and to provide problem-specific implementations. Many applied and pure problems require solution of a large set of linear or nonlinear equations (or inequalities). Highly effective, parallelisable methods are based on iterated projection or reflection algorithms which aggregate information about individual equations. The theory is well developed in the linear case, but does not explain many important applications for which they are often highly successful (eg optical aberration correction, protein reconstruction, tomography, compressed sensing). The project also plans to provide heuristics to help explain why an algorithm performs well on one class of applications but fails on another.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP210101025

    Funder
    Australian Research Council
    Funding Amount
    $400,000.00
    Summary
    Data-Driven Multistage Robust Optimization—the New Frontier in Optimization. Robust optimisation is a powerful technology for decision-making in uncertain environments. Yet, developing numerically certifiable optimisation principles and data-driven methods that can be readily implemented by common computer algorithms remains an elusive goal for multistage robust optimisation. But it is crucial for the practical use of multistage optimisation. This project aims to develop this novel mathematical .... Data-Driven Multistage Robust Optimization—the New Frontier in Optimization. Robust optimisation is a powerful technology for decision-making in uncertain environments. Yet, developing numerically certifiable optimisation principles and data-driven methods that can be readily implemented by common computer algorithms remains an elusive goal for multistage robust optimisation. But it is crucial for the practical use of multistage optimisation. This project aims to develop this novel mathematical theory and methods by extending the investigators' recent award winning advances, including the von Neumann-prizewinning Lasserre-hierarchy approach. Results will provide a foundation and technologies for making superior decisions in the pervasive presence of big data uncertainty, enhancing data-driven innovation in Australia
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