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Research Topic : Copy Number Variations
Australian State/Territory : SA
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  • Funded Activity

    Discovery Projects - Grant ID: DP0451168

    Funder
    Australian Research Council
    Funding Amount
    $150,000.00
    Summary
    A comparative study of generalised solution concepts for elliptic partial differential equations using nonsmooth analysis techniques. The solution of ellpitic partial differential equations is central to science and engineering. There are a number of solution concepts, such as those of weak solutions and viscosity solutions, but the relations between these are incompletely understood. We shall investigate this major question using recent advances in optimisation theory and nonsmooth analysis. .... A comparative study of generalised solution concepts for elliptic partial differential equations using nonsmooth analysis techniques. The solution of ellpitic partial differential equations is central to science and engineering. There are a number of solution concepts, such as those of weak solutions and viscosity solutions, but the relations between these are incompletely understood. We shall investigate this major question using recent advances in optimisation theory and nonsmooth analysis. Our approach is to use various approximations and their associated second-order subdifferentials, each of which implies a generalised solution concept and associated abstract convexity. Particular attention, including computational details, will be given to equations which have very different solutions of one type from those of another.
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    Funded Activity

    Assessing Infrastructure And Contextual Factors In Relation To Cardiometabolic Outcomes In Remote Indigenous Communities: Evidence For Policy Change

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,113,005.00
    Summary
    Cardiometabolic diseases account for the major burden of morbidity and mortality for Indigenous populations. This study with 75 remote Indigenous communities will be the first to evaluate features of their social, built and physical environments in relation to cardiometabolic risks and diseases. Policy-relevant results will identify features of environments to be targeted to reduce chronic diseases for Indigenous peoples in remote communities.
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    Funded Activity

    Discovery Projects - Grant ID: DP160101236

    Funder
    Australian Research Council
    Funding Amount
    $388,294.00
    Summary
    The fundamental equations for inversion of operator pencils. This project seeks to deepen understanding of how complex systems may be significantly changed by incremental changes to ambient conditions. Mathematical models of complex systems (climate change processes, optimal driving strategies, efficient distribution policies, effective search routines) often depend on key parameters. If small perturbations to the parameters cause large changes to the solution, then the perturbations are said to .... The fundamental equations for inversion of operator pencils. This project seeks to deepen understanding of how complex systems may be significantly changed by incremental changes to ambient conditions. Mathematical models of complex systems (climate change processes, optimal driving strategies, efficient distribution policies, effective search routines) often depend on key parameters. If small perturbations to the parameters cause large changes to the solution, then the perturbations are said to be singular. This project aims to reveal the underlying mathematical structures and develop new computational algorithms to analyse a general class of perturbed systems both locally near an isolated singularity and globally. It plans to use these algorithms to solve systems of equations, calculate generalised inverse operators, examine perturbed Markov processes, and estimate exit times from meta-stable states in stochastic population dynamics.
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    Testing The Behavioural And Psychosocial Mechanisms Underlying Geographic Variation In Metabolic Syndrome

    Funder
    National Health and Medical Research Council
    Funding Amount
    $415,457.00
    Summary
    This study seeks to assess the mechanisms that explain the link between residential area features and the metabolic syndrome (obesity and high blood pressure, lipids and glucose), related to cardiometabolic diseases. There is more metabolic syndrome in disadvantaged areas but the reasons for this have not been empirically established. We will evaluate behavioural and psychosocialmechanisms that might independently and jointly explain the association between place and metabolic syndrome.
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    Funded Activity

    Discovery Projects - Grant ID: DP120100567

    Funder
    Australian Research Council
    Funding Amount
    $390,000.00
    Summary
    Structured barrier and penalty functions in infinite dimensional optimisation and analysis. Very large scale tightly-constrained optimisation problems are ubiquitous and include water management, traffic flow, and imaging at telescopes and hospitals. Massively parallel computers can solve such problems and provide physically realisable solution only if subtle design issues are mastered. Resolving such issues is the goal of this project.
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    Funded Activity

    Discovery Projects - Grant ID: DP130104432

    Funder
    Australian Research Council
    Funding Amount
    $600,000.00
    Summary
    Construction of near optimal oscillatory regimes in singularly perturbed control systems via solutions of Hamilton-Jacobi-Bellman inequalities. Problems of optimal control of systems evolving in multiple time scales arise in a great variety of applications (from diet to environmental modelling). This project addresses the challenge of analytically and numerically constructing rapidly oscillating controls that would 'near optimally coordinate' the slow and fast dynamics.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP150100618

    Funder
    Australian Research Council
    Funding Amount
    $379,700.00
    Summary
    Perturbations in Complex Systems and Games. This project aims to: advance the perturbation theory of dynamic and stochastic games; further develop approximations of infinite dimensional linear programs by their finite dimensional counterparts, and by finding asymptotic limits of spaces of occupational measures, by solution of successive layers of fundamental equations; explain and quantify the "exceptionality" of instances of systems that are genuinely difficult to solve; and, capitalise on the .... Perturbations in Complex Systems and Games. This project aims to: advance the perturbation theory of dynamic and stochastic games; further develop approximations of infinite dimensional linear programs by their finite dimensional counterparts, and by finding asymptotic limits of spaces of occupational measures, by solution of successive layers of fundamental equations; explain and quantify the "exceptionality" of instances of systems that are genuinely difficult to solve; and, capitalise on the outstanding performance of our Snakes-and-Ladders Heuristic (SLH) for the solution of the Hamiltonian cycle problem to identify its "fixed complexity orbits" and generalise this notion to other NP-complete problems.
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    Funded Activity

    Discovery Projects - Grant ID: DP120100532

    Funder
    Australian Research Council
    Funding Amount
    $395,000.00
    Summary
    Occupational measures, perturbations and complex deterministic systems. When tackling complex problems, scientists and engineers seek methods that judiciously exploit stochasticity and perturbations as antidotes to unpredictability of outputs that the latter can induce if they inadvertently influence their models. The project proposes for this study vaccine-like perspective of stochasticity and singular perturbations.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP190102674

    Funder
    Australian Research Council
    Funding Amount
    $450,000.00
    Summary
    Two-price quantitative finance. This project aims to establish a novel field, namely two-price quantitative finance, and explore its applications. The new field will integrate two major schools for modelling and explain the presence of two prices, the buying and selling prices, widely observed in the real-world markets, and the equilibrium approach from the fundamental law of one price. The outcomes would deepen our understanding of the fundamental relationship among liquidity, prices, risk and .... Two-price quantitative finance. This project aims to establish a novel field, namely two-price quantitative finance, and explore its applications. The new field will integrate two major schools for modelling and explain the presence of two prices, the buying and selling prices, widely observed in the real-world markets, and the equilibrium approach from the fundamental law of one price. The outcomes would deepen our understanding of the fundamental relationship among liquidity, prices, risk and the economy. This project expects to bring about long-term impact on quantitative finance and related applications through providing a deep understanding of, and a new perspective for, the design, risk and fairness of the finance, property and insurance markets.
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    Funded Activity

    Discovery Projects - Grant ID: DP130103517

    Funder
    Australian Research Council
    Funding Amount
    $405,000.00
    Summary
    G-expectation and its applications to nonlinear risk management. This project will develop novel theories and methods for nonlinear risk management based on nonlinear expectations and Backward Stochastic Differential Equations. The expected outcomes of the project will place Australia in the forefront and the leading position of these fields.
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