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Discovery Early Career Researcher Award - Grant ID: DE120101512
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Investigating the interaction of microRNAs-Wolbachia-Dengue virus in the mosquito vector, Aedes aegypti. This project focuses on using molecular techniques to discover fundamental roles of small RNA molecules (microRNAs) of a key mosquito vector in bacterial symbiosis and Dengue virus infection. It will lead to development of effective approaches in limiting spread of vector and transmission of life threatening viral diseases.
Regulatory cellular microRNAs and their role in insect anti-viral responses. This project will use cutting edge approaches to reveal fundamental roles of small ribonucleic acid molecules (microRNAs) in insect anti-viral responses and immunity. By manipulating anti-viral immune responses, the project will assist in the design of novel approaches to pest control and abolish/limit transmission of vector-borne viruses such as Dengue virus.
Discovery Early Career Researcher Award - Grant ID: DE200100884
Funder
Australian Research Council
Funding Amount
$426,691.00
Summary
Do novel diets reshape wildlife microbiomes and resilience to stressors? This project aims to investigate how bacteria can assist wildlife in adapting to the accelerating threat of environmental change. Using an innovative, interdisciplinary approach this project expects to identify interactions between environmental change and the diet, microbial communities and stress resilience of wildlife, using the threatened Grey-headed flying fox as a model system. Expected outcomes include detailed under ....Do novel diets reshape wildlife microbiomes and resilience to stressors? This project aims to investigate how bacteria can assist wildlife in adapting to the accelerating threat of environmental change. Using an innovative, interdisciplinary approach this project expects to identify interactions between environmental change and the diet, microbial communities and stress resilience of wildlife, using the threatened Grey-headed flying fox as a model system. Expected outcomes include detailed understanding of the role of microbial communities in shaping wildlife adaptations and development of ecological interventions to enhance wildlife resilience in Australia and globally. Such outcomes may reveal opportunities for management strategies that safeguard threatened species and reduce human-wildlife conflicts.Read moreRead less
Discovering how termites use vibrations to thrive in a predators' world. Our recent research revealed termites use vibrations to avoid predators/competitors for survival. However, the enabling mechanisms of this amazing ability remain unknown. The project aims at unlocking the secrets of these mechanisms by relating the mechanical properties of termite, legs, antennae and sensing organs (measured with advanced micro measurement techniques) to vibration signatures of ants and termites (extracted ....Discovering how termites use vibrations to thrive in a predators' world. Our recent research revealed termites use vibrations to avoid predators/competitors for survival. However, the enabling mechanisms of this amazing ability remain unknown. The project aims at unlocking the secrets of these mechanisms by relating the mechanical properties of termite, legs, antennae and sensing organs (measured with advanced micro measurement techniques) to vibration signatures of ants and termites (extracted using innovative signal processing techniques and nonlinear dynamics). We will develop novel bio-dynamics models that incorporate machine learning. We will test the models’ ability to manipulate termites foraging behaviour, with the ultimate objective of developing chemical-free, vibration-based pest control devices. Read moreRead less
Viral and host RNA methylation in mosquitoes. Mosquitoes transmit a variety of viruses to humans and animals through blood feeding. This project aims to investigate one of the most common modifications of RNA molecules, known as N6-methyladenosine (m6A), in an important mosquito vector, Aedes aegypti, and its alterations upon infection with pathogenic as well as mosquito-specific viruses. In addition, m6A modification of viral genomic RNA and its importance in virus replication will be investiga ....Viral and host RNA methylation in mosquitoes. Mosquitoes transmit a variety of viruses to humans and animals through blood feeding. This project aims to investigate one of the most common modifications of RNA molecules, known as N6-methyladenosine (m6A), in an important mosquito vector, Aedes aegypti, and its alterations upon infection with pathogenic as well as mosquito-specific viruses. In addition, m6A modification of viral genomic RNA and its importance in virus replication will be investigated. Expected outcomes of this project include fundamental understanding of RNA methylation in mosquitoes and their role in mosquito biology and virus replication.Read moreRead less
Controlling cane toads by turning their own weapons against them. This project aims to prevent cane toads, which are causing ecological havoc across tropical Australia, from breeding successfully. Attempts to control toad populations have had little impact, but recent research has revealed a new possibility — exploiting the toads' own weapons for intraspecific conflict. Larval cane toads compete intensely with other larval cane toads and as a result, have evolved a way to kill off their competit ....Controlling cane toads by turning their own weapons against them. This project aims to prevent cane toads, which are causing ecological havoc across tropical Australia, from breeding successfully. Attempts to control toad populations have had little impact, but recent research has revealed a new possibility — exploiting the toads' own weapons for intraspecific conflict. Larval cane toads compete intensely with other larval cane toads and as a result, have evolved a way to kill off their competitors. Toad tadpoles produce chemicals that have devastating effects on younger members of their own species, but not on native species. By deploying those chemicals, this project could develop a novel and powerful form of invader control.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100083
Funder
Australian Research Council
Funding Amount
$540,000.00
Summary
A high throughput phenomics facility for pace of life traits in animals. A high throughput phenomics facility for pace of life traits in animals: This project seeks to create the first high-throughput phenomic facility for animals in Australia. The molecular revolution has brought unprecedented capacity to understand genetic variation. Genetic variation is now better understood and more easily and cheaply characterised than the physical traits that organisms exhibit. Linking phenotypic variation ....A high throughput phenomics facility for pace of life traits in animals. A high throughput phenomics facility for pace of life traits in animals: This project seeks to create the first high-throughput phenomic facility for animals in Australia. The molecular revolution has brought unprecedented capacity to understand genetic variation. Genetic variation is now better understood and more easily and cheaply characterised than the physical traits that organisms exhibit. Linking phenotypic variation to genetic variation represents the major challenge in harnessing the power of the biomolecular age. This facility will accommodate animals from marine, freshwater and terrestrial systems across a diverse array of phyla. It will allow Australian researchers to leverage advances in high throughput genomic technologies to address a major bottleneck in biology.Read moreRead less
The role of behavioural interactions in shaping invasion dynamics: A global synthesis using the common myna as a model system. Invasive species have detrimental effects on human health, the economy and native biodiversity. This study will address a major gap in our scientific understanding of invasions by undertaking the first large-scale examination of the role of interactions between species in determining the dynamics and outcomes of biological invasions. The project will integrate data, acro ....The role of behavioural interactions in shaping invasion dynamics: A global synthesis using the common myna as a model system. Invasive species have detrimental effects on human health, the economy and native biodiversity. This study will address a major gap in our scientific understanding of invasions by undertaking the first large-scale examination of the role of interactions between species in determining the dynamics and outcomes of biological invasions. The project will integrate data, across four continents, on dispersal, demography, breeding and behavioural interactions into one framework to create a cutting-edge model of invasion dynamics, using the highly invasive common myna as a model system. This novel approach will significantly advance theoretical developments in invasion biology and will inform pest management and threat mitigation efforts globally.Read moreRead less
Novel disinfection to combat antibiotic resistance . Control of antimicrobial resistance in water is critical. Disinfection in water and wastewater treatment plants is a vital barrier against antibiotic resistant bacteria (ARB); however, it is less effective in controlling- and may even facilitate the spread of antibiotic resistance genes (ARGs). This project aims to comprehensively investigate the effectiveness of widely-used disinfection processes in controlling ARB/ARGs, determine the underly ....Novel disinfection to combat antibiotic resistance . Control of antimicrobial resistance in water is critical. Disinfection in water and wastewater treatment plants is a vital barrier against antibiotic resistant bacteria (ARB); however, it is less effective in controlling- and may even facilitate the spread of antibiotic resistance genes (ARGs). This project aims to comprehensively investigate the effectiveness of widely-used disinfection processes in controlling ARB/ARGs, determine the underlying mechanisms, and identify optimal treatment conditions. This project also aims to develop a novel, cost-effective and environmentally friendly disinfection process for efficient ARGs destruction, thus significantly strengthening Australia’s capacity to prevent the spread of antibiotic resistance.Read moreRead less
Backyard Bandicoots: Engaging community in urban bushland conservation. Backyard bandicoots: Engaging community in urban bushland conservation. This project aims to develop a model for urban ecosystem function and restoration, by identifying resources used by urban bandicoots (quenda). Digging mammal species turn over substantial volumes of soil as they forage for invertebrates, subterranean fungi, and plant material. These ecosystem engineers contribute to water infiltration, nutrient cycling, ....Backyard Bandicoots: Engaging community in urban bushland conservation. Backyard bandicoots: Engaging community in urban bushland conservation. This project aims to develop a model for urban ecosystem function and restoration, by identifying resources used by urban bandicoots (quenda). Digging mammal species turn over substantial volumes of soil as they forage for invertebrates, subterranean fungi, and plant material. These ecosystem engineers contribute to water infiltration, nutrient cycling, increased soil microorganism function, and seedling recruitment. They spread hypogeous mycorrhizal fungi that contribute to plant nutrition, crucial in Australia's nutrient-poor soils. This research is expected to improve targeted plantings in bushland reserves, and identify and mitigate threats to bandicoots in cities.Read moreRead less