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VULNERABILITY OF THE INTRAUTERINE GROWTH RESTRICTED HEART AND KIDNEY TO ELEVATIONS IN BLOOD GLUCOSE LEVELS IN ADULTHOOD
Funder
National Health and Medical Research Council
Funding Amount
$58,288.00
Summary
It is proposed that the hearts and kidneys of subjects that were born small for gestational age are particularly vulnerable to the pathophysiological changes induced by hyperglycemia, even when blood glucose levels are only mildly elevated. In the present project, this concept will be investigated. The outcomes of this study will be particularly relevant to the Australian Aboriginal population, as they have a higher incidence than normal of low birth weight and impaired glucose metabolism.
The prevalence of maternal obesity is alarmingly high in Australia and the western world. However, there is little understanding of how obesity of the mother affects the development of the kidney of the fetus and, in turn, how this affects the risk of these offspring developing cardiovascular and renal disease in adulthood. I hope to address the gaps in this knowledge in my studies. This information is critical in order to develop appropriate health care to those born to obese mothers.