Australian Laureate Fellowships - Grant ID: FL130100039
Funder
Australian Research Council
Funding Amount
$2,750,000.00
Summary
New stochastic models for Science, Economics, Social Science and Engineering. Stochastic, or random, phenomena abound in society. This project will combine advancement of the theory of stochastic models at a deep level with application to problems arising in science, economics, social science and engineering, and outreach to educate members of the public about random processes of significance in their lives.
Australian Laureate Fellowships - Grant ID: FL190100014
Funder
Australian Research Council
Funding Amount
$2,871,982.00
Summary
New Technologies for Delivering Sustainable Free-form Architecture. This project aims to harness the full potential of digital technologies to significantly enhance the performance and reduce the environmental impact of free-form architecture of the future. The research expects to establish a fundamentally new computational platform capable of producing diverse and competitive designs, and an environmentally friendly manufacturing process for realising such designs. Expected outcomes include an ....New Technologies for Delivering Sustainable Free-form Architecture. This project aims to harness the full potential of digital technologies to significantly enhance the performance and reduce the environmental impact of free-form architecture of the future. The research expects to establish a fundamentally new computational platform capable of producing diverse and competitive designs, and an environmentally friendly manufacturing process for realising such designs. Expected outcomes include an unprecedented cloud-based interactive design tool, and a novel minimum-waste manufacturing technology for fabricating mass-customised building components. This project will transform the architecture, engineering and construction (AEC) sector and make the Australian manufacturing industry more competitive globally.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100019
Funder
Australian Research Council
Funding Amount
$2,606,250.00
Summary
Proteins in motion - new tools for biotechnology. This project aims to assess the function of proteins by monitoring their motions using new nuclear magnetic resonance (NMR) spectroscopy techniques. As snapshots of 3D protein structures have been determined by crystallography, the new tools are designed to analyse functionally important motions in solution. A facility for ultrafast (> 100 kHz) magic angle spinning NMR spectroscopy of proteins in the semi-solid state will bring cutting-edge know- ....Proteins in motion - new tools for biotechnology. This project aims to assess the function of proteins by monitoring their motions using new nuclear magnetic resonance (NMR) spectroscopy techniques. As snapshots of 3D protein structures have been determined by crystallography, the new tools are designed to analyse functionally important motions in solution. A facility for ultrafast (> 100 kHz) magic angle spinning NMR spectroscopy of proteins in the semi-solid state will bring cutting-edge know-how to Australia and allow the interrogation of 3D structure and dynamics in selected protein regions. The expected outcomes of the project will have immediate benefits for the rational engineering of biocatalysts and in the design of lead compounds in drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100019
Funder
Australian Research Council
Funding Amount
$2,906,976.00
Summary
An in situ structural study of Drosophila embryonic patterning. This project aims to develop and deploy an in situ structural biology approach, which enables direct visualisation of large macromolecular structures in cells, to be used in combination with molecular genetics, proteomics and computational biology. In situ structural biology has the potential to revolutionise discovery across life science, providing direct insight into macromolecular structure and function. This project will establi ....An in situ structural study of Drosophila embryonic patterning. This project aims to develop and deploy an in situ structural biology approach, which enables direct visualisation of large macromolecular structures in cells, to be used in combination with molecular genetics, proteomics and computational biology. In situ structural biology has the potential to revolutionise discovery across life science, providing direct insight into macromolecular structure and function. This project will establish the field of in situ structural biology in Australia by studying how a model organism, the fruit fly Drosophila melanogaster controls the development of how the head and tail of the embryo are specified. The project will further develop new instrumentation and approaches that will bring in situ biology to the wider scientific community.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100049
Funder
Australian Research Council
Funding Amount
$2,915,738.00
Summary
A molecular investigation into immune function. A molecular investigation into immune function. The project aims to understand how key immune recognition events enable immunity. This project would use a multidisciplinary approach empowered by technological innovations, including the latest advances in atomic and molecular imaging. This research is expected to identify new approaches for the biotechnology industry.
Australian Laureate Fellowships - Grant ID: FL150100146
Funder
Australian Research Council
Funding Amount
$2,977,310.00
Summary
Taking Australia from the farm to the pharm. Taking Australian from the farm to the pharm: This fellowship project aims to design novel drugs based on cyclic peptides that will be expressed in the seeds of plants to produce bio-pills — saving money for patients and the health care system. Plants produce unique cyclic peptides (mini-proteins) to protect themselves from pests and pathogens. This project aims to chemically redesign these peptides to produce stable protein-based pharmaceuticals that ....Taking Australia from the farm to the pharm. Taking Australian from the farm to the pharm: This fellowship project aims to design novel drugs based on cyclic peptides that will be expressed in the seeds of plants to produce bio-pills — saving money for patients and the health care system. Plants produce unique cyclic peptides (mini-proteins) to protect themselves from pests and pathogens. This project aims to chemically redesign these peptides to produce stable protein-based pharmaceuticals that can be eaten. It is hoped that these designer pharmaceuticals will be inexpensive, effective, easy to ingest and without the side effects of traditional drugs. The outcomes of this project are anticipated to be high-value drugs and agri-chemicals which will open up new high-value crops for Australian farmers and a new Australian ‘pharming’ industry.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992179
Funder
Australian Research Council
Funding Amount
$2,985,000.00
Summary
Adapting the sustainable exploitation of coral reef resources to provide for climate change. The research program quantifies the impacts of climate change on coral reefs and harnesses remote sensing technology and ecological modelling to provide new tools for reef management. Research outcomes will help bodies such as the Great Barrier Reef Marine Park Authority adapt their management of marine production systems to take account of climate change, and thereby help ensure the sustainable delivery ....Adapting the sustainable exploitation of coral reef resources to provide for climate change. The research program quantifies the impacts of climate change on coral reefs and harnesses remote sensing technology and ecological modelling to provide new tools for reef management. Research outcomes will help bodies such as the Great Barrier Reef Marine Park Authority adapt their management of marine production systems to take account of climate change, and thereby help ensure the sustainable delivery of ecosystem services including tourism, recreation, fisheries, and the sustainability of Australia's marine biodiversity. Algorithms generated by the study will also help resource managers better target their actions, which improves both conservation benefits and value for money.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100109
Funder
Australian Research Council
Funding Amount
$2,762,247.00
Summary
Unifying mechanisms of innate immunity signaling in animals and plants. This project aims to improve our understanding of innate immunity, the first line of defense against pathogens in diverse organisms. Innate immune pathways are key to a range of pathological states in animals, and provide plants with resistance to the diseases that account for 15% of crop losses. This project will generate knowledge, through characterising mechanisms of cell signalling for mammalian and plant innate immunity ....Unifying mechanisms of innate immunity signaling in animals and plants. This project aims to improve our understanding of innate immunity, the first line of defense against pathogens in diverse organisms. Innate immune pathways are key to a range of pathological states in animals, and provide plants with resistance to the diseases that account for 15% of crop losses. This project will generate knowledge, through characterising mechanisms of cell signalling for mammalian and plant innate immunity. The outcomes will include a unified signalling model, and form the foundation for a range of applications in human biology and agriculture, such as the development of durable and effective resistance in crops.Read moreRead less