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Proteins Involved In HIV Infection And Host Defense
Funder
National Health and Medical Research Council
Funding Amount
$323,244.00
Summary
I am a biochemist focused on answering the question: why is it that humans are susceptible to HIV infection, while certain monkeys are resistant? It is known that these monkeys have evolved proteins which can target and destroy the virus, but the equivalent human proteins don’t work against HIV. I intend to compare the monkey and human proteins to understand how the monkeys destroy the virus and why the human protein is defective. These studies will inform the next generation of HIV treatment.
How Do TRIM21 And TRIM5α Execute Dual Antiviral Effector And Signalling Functions?
Funder
National Health and Medical Research Council
Funding Amount
$344,724.00
Summary
We encounter millions of potential pathogens each day that must be detected and disarmed by the immune system. Recently, two antiviral proteins, present inside cells, were shown to both detect viruses, alerting neighbouring cells to the infection, and target the viruses for destruction. These two functions provide important protection against viral infection and this research aims to understand at a molecular level, how these dual antiviral functions are coordinated.
Inhibition Of Cellcell Actin-based Motility During Poxvirus Infection By The Kinase Inhibitor Glivec
Funder
National Health and Medical Research Council
Funding Amount
$92,950.00
Summary
Although smallpox, one of the deadliest human pathogens, was eradicated in 1980, the current global climate has resulted in fears that smallpox may be used as a biological weapon. Unfortunately the smallpox vaccine poses a serious health hazard to certain people. We have shown that Glivec, a drug used to treat cancer, has potent anti-viral affects on poxvirus replication. This project will test the effectiveness of Glivec in treating smallpox in an animal model and study how it acts.
Genetic And Environmental Risk Factors On Lifetime Risk Of Obstructive Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$351,414.00
Summary
Classification of lifetime phenotypes of obstructive lung disease allows investigation of the effect of environmental and genetic influences on specific phenotypes along with the interactions between them. Through improved phenotyping ,the currently inconsistent relationships between asthma and COPD and their associations with genetic and environmental factors may become clearer.
Interaction Of Amyloid-beta And Tau Pathology In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$122,592.00
Summary
Currently, over 200,000 Australians are affected by Alzheimer's disease (AD) and related forms of dementia, causing a huge socio-economic damage. To overcome the lack of effective treatments, we need to understand the underlying causes and translate them into therapy. Using state-of-the-art cell culture and genetic mouse models, I will reveal fundamental processes in AD and related dementias, and develop tailored treatments to battle these devastating disorders.
Transcriptome Characterization Of Klebsiella Pneumoniae During Infection (TRACKIN)
Funder
National Health and Medical Research Council
Funding Amount
$348,806.00
Summary
Klebsiella pneumoniae (KP) is an important pathogen associated with high mortality and antimicrobial resistance. Upon infection, the host activates a sophisticated immune response, but there is evidence that KP is capable of modifying this response. Here I will take advantage of cutting-edge genome sequencing to understand the interactions between KP and host immunity. These studies will provide a pathway for the development of new therapeutic strategies to combat multiresistant infections.
The Proteomics Of The Von Hippel-Lindau (VHL) Tumour Suppressor Protein
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
This project primarily intends to identify novel modifications to the von Hippel-Lindau (VHL) protein which plays a role in tumour suppression and blood vessel growth. It is the purpose of this project to characterise these changes to VHL and ultimately, understand what these changes mean to the function of VHL protein, and modulate them to ameliorate VHL disease.