A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identifi ....A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identification of key wiring principles for developing brains, and an understanding of how these principles shape behaviour. This work will shed new light on the developmental processes that underlie human behaviour and disease.Read moreRead less
Spatiotemporal signatures of learning in brain reward systems. Learning to strengthen behaviours that secure resources and warrant survival is one of the primary functions of the brain. This Project seeks to establish the rules that govern the integration of learning in brain reward systems by studying how neuronal circuits change their molecular signatures as animals assimilate new knowledge. These studies will combine novel experimental designs to investigate learning with multidisciplinary me ....Spatiotemporal signatures of learning in brain reward systems. Learning to strengthen behaviours that secure resources and warrant survival is one of the primary functions of the brain. This Project seeks to establish the rules that govern the integration of learning in brain reward systems by studying how neuronal circuits change their molecular signatures as animals assimilate new knowledge. These studies will combine novel experimental designs to investigate learning with multidisciplinary methods for mapping, recording and functionalising teaching signals in behaving mice. The outcomes will create a significant shift in our understanding of the neural bases that underlie reward learning, and will critically expand the field by providing a new model of learning integration in brain systems.Read moreRead less
Mechanisms of memory integration in brain systems. Learning from our interactions with the environment is one of the brain’s most important functions, yet how and where this process takes place at the neural network level has proven difficult to establish. This Project seeks to investigate how major neuromodulatory signals in the brain coordinate the encoding of reward-based learning in large ensembles of neurons. These studies will combine novel behavioural paradigms with the most recent neuros ....Mechanisms of memory integration in brain systems. Learning from our interactions with the environment is one of the brain’s most important functions, yet how and where this process takes place at the neural network level has proven difficult to establish. This Project seeks to investigate how major neuromodulatory signals in the brain coordinate the encoding of reward-based learning in large ensembles of neurons. These studies will combine novel behavioural paradigms with the most recent neuroscience techniques for functional mapping and manipulation of specific neural circuits in behaving mice. The outcomes of this research will lead to a significant shift in our understanding of the mechanisms underpinning the integration of learning in brain systems and its implications for behaviour.Read moreRead less
How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project ....How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project expects to provide new knowledge on when, where and how hindbrain neurons control environment-driven food-seeking behaviours. This should provide benefits to the advancement of knowledge on the neural mechanisms of food-seeking and provide a basic science platform for future research on the study of feeding behaviours.
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Designing work roles for crew operating multiple unmanned aircraft. The aim of this project is to identify how work roles should be designed for crew operating multiple Unmanned Aircraft (UA). Industry expects that the introduction of higher levels of automation in next-generation UA systems will reduce the operational costs associated with UA by enabling human crews to simultaneously manage multiple aircraft. The current project examines the safety and effectiveness of different types of work d ....Designing work roles for crew operating multiple unmanned aircraft. The aim of this project is to identify how work roles should be designed for crew operating multiple Unmanned Aircraft (UA). Industry expects that the introduction of higher levels of automation in next-generation UA systems will reduce the operational costs associated with UA by enabling human crews to simultaneously manage multiple aircraft. The current project examines the safety and effectiveness of different types of work designs for these systems. The primary outcome will be a set of recommendations regarding the design of work roles for the crew of next-generation UA systems. Expected benefits include improvements in safety and cost-effectiveness of next-generation UA systems.Read moreRead less
Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between ....Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between these factors is unknown. The outcomes of the current grant will provide the first evidence of that link, thus providing deeper understanding of the neurophysiological mechanisms of these disorders, which could eventuate in the creation of more beneficial treatments. Read moreRead less
Reading facial expressions from real and virtual humans. This project aims to advance understanding of human emotional communication and improve human rapport with the virtual humans and avatars that are rapidly infiltrating our social world. Using two unique stimulus sets - naturalistic human expressions and highly realistic virtual faces - together with powerful genetic, experimental, and individual differences designs, the project expects to answer previously intractable questions in emotion ....Reading facial expressions from real and virtual humans. This project aims to advance understanding of human emotional communication and improve human rapport with the virtual humans and avatars that are rapidly infiltrating our social world. Using two unique stimulus sets - naturalistic human expressions and highly realistic virtual faces - together with powerful genetic, experimental, and individual differences designs, the project expects to answer previously intractable questions in emotion science, as well as deliver tangible outcomes, such as new psychological tests to better understand human social connection. This should provide significant benefits, by improving emotion communication and offering a new perspective on how artificial intelligence can best serve human social needs.
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Discovery Early Career Researcher Award - Grant ID: DE210101107
Funder
Australian Research Council
Funding Amount
$412,744.00
Summary
Ahead of the Game: Balancing the Gaming Industry and Public Interest. This project battles the risks and embraces the benefits of digital gaming. There is a risk that one loses control of their gaming and prioritises it over other duties. This is offset by the benefits of using digital games for health. It is the first to decode and use the health data embedded in the connection between the gamer and their game persona (avatar). It does this by concurrently assessing important gamer, family, cul ....Ahead of the Game: Balancing the Gaming Industry and Public Interest. This project battles the risks and embraces the benefits of digital gaming. There is a risk that one loses control of their gaming and prioritises it over other duties. This is offset by the benefits of using digital games for health. It is the first to decode and use the health data embedded in the connection between the gamer and their game persona (avatar). It does this by concurrently assessing important gamer, family, cultural and game structure features. Findings will prompt the ethical growth of the Australian Health games industry and inform strategies to combat gaming disorder by tailoring games to users' needs. This will uniquely benefit Australians by re-directing this growing industry to better serve the public interest.Read moreRead less
The impact of female sex hormones on neurodevelopment. This project aims to characterise the contribution of sex hormones to the development of emotional brain circuits in female adolescents. Puberty is associated with profound changes in emotional behaviours in females, but we know little about the underlying brain mechanisms. In particular, research has neglected to consider the role of the sex hormones for which changes are a defining feature of female puberty (eg, oestradiol). This work will ....The impact of female sex hormones on neurodevelopment. This project aims to characterise the contribution of sex hormones to the development of emotional brain circuits in female adolescents. Puberty is associated with profound changes in emotional behaviours in females, but we know little about the underlying brain mechanisms. In particular, research has neglected to consider the role of the sex hormones for which changes are a defining feature of female puberty (eg, oestradiol). This work will be the first to comprehensively advance our understanding of the unique role of sex hormones in shaping the adolescent female brain. It will provide critical understanding of how individual differences in hormonal factors increase risk for emotional problems in females, and inform treatment strategies.Read moreRead less
Square Eyes or All Lies? Understanding Children's Exposure to Screens. This project will examine Australian parents’ number one concern about their children’s health and behaviour – their interactions with electronic screens. Current screen time guidelines are based on low-quality evidence and lack the nuance required to address this complex issue. This project will use innovative technology to resolve these weaknesses. Wearable cameras will measure what children are doing on screens, and where, ....Square Eyes or All Lies? Understanding Children's Exposure to Screens. This project will examine Australian parents’ number one concern about their children’s health and behaviour – their interactions with electronic screens. Current screen time guidelines are based on low-quality evidence and lack the nuance required to address this complex issue. This project will use innovative technology to resolve these weaknesses. Wearable cameras will measure what children are doing on screens, and where, when, and how long they are doing it. The project will also investigate how screen time impacts children’s development and how it is influenced by their environment. This evidence will benefit children by improving screen time guidelines, and help parents understand the impact of screen time on children’s development.
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