Drug particle characterisation. The understanding of drug particle characterizations is one of the key issues in the development of novel nasal sprayers for targeted drug delivery. A comprehensive study is proposed for characterising drug formation in sprayers and particle deposition in nasal cavity using the latest experimental and numerical techniques. A computer-aided design technology will be developed to optimise drug delivery systems. The new technology has great potentials leading to the ....Drug particle characterisation. The understanding of drug particle characterizations is one of the key issues in the development of novel nasal sprayers for targeted drug delivery. A comprehensive study is proposed for characterising drug formation in sprayers and particle deposition in nasal cavity using the latest experimental and numerical techniques. A computer-aided design technology will be developed to optimise drug delivery systems. The new technology has great potentials leading to therapeutic and economic benefits in developing advanced/innovative drug delivery systems and in evaluating the potential biological effects by the drugs to be introduced through the nose.Read moreRead less
OPTIMIZED NASAL DRUG DELIVERY SYSTEMS -- COMPUTER AIDED DESIGN. The aim of this project is to develop a computer-aided design technology to assist in targeted drug delivery through the human nasal cavity which is being recognised to be an excellent alternative route for the administration of medication drugs. The aim will be achieved by conducting computer modelling of nasal flow under realistic physiological conditions and by performing experimental measurements and testing to validate computer ....OPTIMIZED NASAL DRUG DELIVERY SYSTEMS -- COMPUTER AIDED DESIGN. The aim of this project is to develop a computer-aided design technology to assist in targeted drug delivery through the human nasal cavity which is being recognised to be an excellent alternative route for the administration of medication drugs. The aim will be achieved by conducting computer modelling of nasal flow under realistic physiological conditions and by performing experimental measurements and testing to validate computer models. The new technology has great potentials leading to therapeutic and economical benefits in developing advanced/innovative drug delivery systems and in evaluating the potential biological effects by the drugs to be introduced through the nose.Read moreRead less
Computational haemodynamics system for prediction of risk of rupture of cerebral aneurysms. Every year about 2000 Australians suffer a ruptured aneurysm in the brain and some 750 of these die within 4 weeks. Since there is an increase in the detection of unruptured aneurysms, especially in healthy young people, there is an urgent need to be able to decide which lead to rupture and to provide suitable treatment options. This project, which will provide markedly improved means of patient-specific ....Computational haemodynamics system for prediction of risk of rupture of cerebral aneurysms. Every year about 2000 Australians suffer a ruptured aneurysm in the brain and some 750 of these die within 4 weeks. Since there is an increase in the detection of unruptured aneurysms, especially in healthy young people, there is an urgent need to be able to decide which lead to rupture and to provide suitable treatment options. This project, which will provide markedly improved means of patient-specific risk determination for aneurysm rupture, will have significant impact in reducing associated costs on the national health burden due to cerebral hemorrhage and stroke, on community productivity and disability and on more efficient targeting of expensive and dangerous brain surgery.Read moreRead less
Our overall objective is to significantly improve the efficacy and efficiency of image-guided neurosurgery for brain tumours by including realistic computation of brain deformations, based on a biomechanical model, in a system to improve intra-operative visualisation, navigation and monitoring. The system will create an augmented reality visualisation of the intra-operative configuration of the patient’s brain merged with high resolution pre-operative imaging data.
Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth res ....Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth research of vascular diseases but also provide a virtual forecasting tool for physicians or surgeons to develop guidance on diagnosis and therapeutic planning of clinical treatment, which brings great socio-economic benefit to the health of the Australian community.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668502
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Queensland Computational Grid Enhancement Project. State-of-the-art computational facilities will be made available to enhance research outcomes in vital areas such as environmental and sustainability modelling, security and medical engineering and thus play an important role in advancing scientific and engineering discovery within Queensland and Australia. The new computational systems will be made available on a Queensland wide basis through the Queensland Parallel Supercomputing Foundation an ....Queensland Computational Grid Enhancement Project. State-of-the-art computational facilities will be made available to enhance research outcomes in vital areas such as environmental and sustainability modelling, security and medical engineering and thus play an important role in advancing scientific and engineering discovery within Queensland and Australia. The new computational systems will be made available on a Queensland wide basis through the Queensland Parallel Supercomputing Foundation an initiative supported by Queensland universities and the State Government. The new infrastructure will support more than 390 researchers, is consistent with the national supercomputing framework and directly supports ARC research that addresses all four key national research priorities.Read moreRead less
Patient-specific Modelling Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Cardiovascular disease is undoubtedly the biggest killer in the developed world and accounts for 30% of all deaths in Australia; killing one Australian every twelve minutes. My research group and I, combine medical imaging with biomedical engineering to perform patient-specific modelling. For example, we can predict the likelihood that aneurysm will rupture or the way blood flows through the aorta. My goal is to make these modelling tools accurate and robust enough to be used in the clinic.
Approximately 7% of elderly men have an abdominal aortic aneurysm (AAA) and AAA rupture usually results in death. This research aims to improve the limitations in AAA risk assessment. Currently, the maximum diameter determines if the aneurysm is at risk of rupture. However, many small AAAs rupture and 75% of larger ones never burst. Using computer models generated from medical imaging can substantially improve the understanding of rupture risk, therefore, saving lives and reducing health care co ....Approximately 7% of elderly men have an abdominal aortic aneurysm (AAA) and AAA rupture usually results in death. This research aims to improve the limitations in AAA risk assessment. Currently, the maximum diameter determines if the aneurysm is at risk of rupture. However, many small AAAs rupture and 75% of larger ones never burst. Using computer models generated from medical imaging can substantially improve the understanding of rupture risk, therefore, saving lives and reducing health care costs.Read moreRead less
Tissue-like, nonlinearly elastic nanobiomaterials for soft tissue regeneration. The purpose of this project is to advance the discipline of soft tissue engineering and regeneration with novel biomaterials, nanotechnology and novel clinical treatment concepts. The key outcomes include new elastic tissue-like nanobiomaterials, new varieties of medical implants and innovative treatment methodology.
Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes wi ....Microfluidic technology to help understand physical damage to brain cells. Understanding the organisation, structure and mechanisms of the human brain and nervous system remains one of the biggest challenges of science. This project aims to develop a new cell culture platform to form defined molecular networks of brain cells and to monitor changes throughout the network in response to a small localised injury within the network. This innovative platform will be used to help understand changes within cells in response to physical damage to networks of brain cells. This is one of the major causes of death and disability in developed nations, and is identified as a risk factor for a range of neurodegenerative diseases including Alzheimer's, Parkinson's and motor neuron disease.Read moreRead less