A Method for Analysis of Complexity in Cognitive Processes: Applications to Prediction of Industrial Workloads. The project will develop a method for analysis of cognitive complexity in human and animal cognition. It will contribute to basic research because it will enable equivalences and relative complexities of cognitive functions to be determined, independent of content or methodology. It will have applications to education, because it enables complexities of concepts to be recognised and a ....A Method for Analysis of Complexity in Cognitive Processes: Applications to Prediction of Industrial Workloads. The project will develop a method for analysis of cognitive complexity in human and animal cognition. It will contribute to basic research because it will enable equivalences and relative complexities of cognitive functions to be determined, independent of content or methodology. It will have applications to education, because it enables complexities of concepts to be recognised and appropriate pedagogies determined. It also has application to human factors, especially industrial performance and decision making. It will advance on currrent methods because it enables workload to be analysed and predicted, so that it can be factored into job and system design. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100293
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a l ....Cracking the phosphoinositide code. This project seeks to determine how protein interactions with membrane lipids regulate recruitment to cellular organelles, providing new insight into the complex pathways of cellular homeostasis. Controlling the distribution of proteins within cells is critical for cell signalling and membrane trafficking. This is orchestrated by the interaction of specific protein modules with lipids on the surface of different organelles. The phox homology (PX) domain is a lipid-binding module found in numerous proteins essential for normal cell trafficking and homeostasis, and perturbed in many conditions including immune dysfunction and cancer. This project plans to investigate molecular determinants of PX-lipid association, generating knowledge about protein-membrane interactions required for cellular function. These insights may underpin future drug design.Read moreRead less