Cyclic-nucleotide-dependent Regulation Of Axon Guidance Sensitivity
Funder
National Health and Medical Research Council
Funding Amount
$527,338.00
Summary
Problems in wiring up the brain underlie several nervous system disorders. The goal of this project is to understand better how this wiring normally forms. This will ultimately lead to a better understanding of what can go wrong with brain wiring, and how to fix such problems. It will also lead to a better understanding of how to make axons regenerate after injury.
Colorectal cancer is a common malignancy in Australia and the mutation of one gene (Apc) is implicated in >80% of the cases. We aim to understand Apc biochemistry in normal and colon cancer cells by integrating mathematics with our experimental biology program. The main outcomes for this project will be a better understanding of the regulatory systems perturbed in colon cancer. We believe that the insights gained by our research will point the way to more effective treatments of colon cancer.
From Maps To Efficient Multi-parasite Control In The Philippines
Funder
National Health and Medical Research Council
Funding Amount
$358,121.00
Summary
Schistosomiasis and soil-transmitted helminths are major parasitic infections in Asia, causing anaemia, poor growth and poor school performance and death in some chronic schistosomiasis cases. We will use maps to demonstrate the geographic distribution of these parasites in the Philippines. We will estimate the impact and costs and benefits of parasite control programmes. This research will help plan more efficient parasite control and reduce the impact of these infections in the Philippines.
Early Detection Of MCI And Dementia Using Multidimensional Analysis Of Structural MRI By Computational Methods
Funder
National Health and Medical Research Council
Funding Amount
$583,601.00
Summary
Dementia in elderly is a major public health problem, and mild cognitive impairment (MCI), is even more common. We propose to use recent computational anatomy algorithms from our group to develop novel multidimensional imaging biomarkers for early detection of brain anatomical changes due to MCI-dementia. We aim at identifying early signatures of MCI-dementia, thus making early treatment possible. The completion of our research will provide clinicians with new methods for the early diagnosis.
Fitness Versus Fatness: Disentangling Their Effects On Disease Outcomes And Estimating The Population Burden Of Disease
Funder
National Health and Medical Research Council
Funding Amount
$188,537.00
Summary
Overweight and physical inactivity are two of the major risk factors for cardiovascular disease and diabetes. With increasing population levels of overweight, governments are increasingly advocating public health measures aimed at increasing physical activity levels or otherwise decreasing weight. There has been much research concerning which of these factors is the key prognostic factor for adverse health outcomes, but an ongoing lack of clarity of research findings has led to uncertainty as to ....Overweight and physical inactivity are two of the major risk factors for cardiovascular disease and diabetes. With increasing population levels of overweight, governments are increasingly advocating public health measures aimed at increasing physical activity levels or otherwise decreasing weight. There has been much research concerning which of these factors is the key prognostic factor for adverse health outcomes, but an ongoing lack of clarity of research findings has led to uncertainty as to the direction of recommendations for preventive health strategies and population lifestyle changes. In addition, the risks of overweight, in particular, have been accused of being exaggerated in both the scientific and lay literature. This is often due to the difficulty of dealing appropriately with time varying confounders which are also intermediate factors (such as hypertension). To date, no studies have performed careful longitudinal modelling of the joint effects of physical inactivity and overweight on cardiovascular events and diabetes while taking into account the effects of factors, such as hypertension or atherosclerosis, that influence both physical activity and overweight as well as disease, and simultaneously are consequences of these risk factors. Standard statistical methods are known to produce biased estimates in these situations but we will apply more recently developed statistical techniques to provide much improved estimation of these effects. After the statistical modelling stage, we will model the burden of diabetes, cardiovascular disease and mortality associated with given levels of overweight and physical inactivity. These will be combined with population levels of overweight and inactivity to identify the fraction of the current and future burden of disease attributable to these risk factors.Read moreRead less